Results 61 to 70 of about 4,673 (179)

Metabolic Redox Modulation by Agaricus bisporus Aqueous Extract in Honey Bee Cells

Molecules
The western honey bee (Apis mellifera) is increasingly exposed to environmental stressors that affect redox homeostasis, leading to imbalances in cellular functions.
Đura Nakarada, Uroš Glavinić, Jevrosima Stevanović, Uroš Gašić, Marko Ristanić, Miloš Mojović, Zoran Stanimirović   +6 more
doaj   +1 more source

Disarming the Pathogen's Metabolic Weapon: A Novel Route to Durable Disease Resistance

Modern Agriculture, Volume 4, Issue 1, June 2026.
Two routes to sugar acquisition in pathogenic bacteria and corresponding ‘pathogen‐starvation’ strategies. TAL effectors activate plant SWEET transporters to promote sucrose efflux into the apoplast, which can be blocked by editing SWEET promoter effector‐binding elements to prevent TAL binding. The T3E AvrBs2 converts host UDP‐galactose into xanthosan,
Yixuan Mi, Yuheng Yang
wiley   +1 more source

Hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for the quantification of uridine diphosphate-glucose, uridine diphosphate-glucuronic acid, deoxynivalenol and its glucoside: In-house validation and application to wheat

, 2015
Nucleotide sugars, the activated forms of monosaccharides, are important metabolites involved in a multitude of cellular processes including glycosylation of xenobiotics.
Lemmens, Marc, Adam, Gerhard, Warth, Benedikt, Siegwart, Gerald, Krska, Rudolf, Schuhmacher, Rainer   +5 more
core   +1 more source

Engineering the bacterial nutrition strategy to control plant diseases

Journal of Integrative Plant Biology, Volume 68, Issue 6, Page 1601-1603, June 2026.
This commentary on Wang et al. (2025) and Phan et al. (2025) highlights previously undiscovered Xanthomonas pathways for nutrition acquisition, explains how Xanthomonas bacteria hijack host molecular machinery through their effector proteins, and discusses how these studies can be used to develop new disease resistance mechanisms.
Muhammad Arslan Mahmood, Shahid Mansoor, Muhammad Naveed Aslam   +2 more
wiley   +1 more source

Engineered Saccharomyces cerevisiae as a Biosynthetic Platform of Nucleotide Sugars

Glycosylation of biomolecules can greatly alter their physicochemical properties, cellular recognition, subcellular localization, and immunogenicity.
Samantha A. Crowe (18137895), Graham A. Hudson (3215463), Maria C. T. Astolfi (18137898), Xixi Zhao (4251673), Jay D. Keasling (51716), Fei Gan (142010), Henrik V. Scheller (4099900), Yuzhong Liu (1936123), Xiaoyue Chen (334717)   +8 more
core   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, Volume 65, Issue 22, 25 May 2026.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Capillary electrophoretic study on UDP-sugars in cells

, 2000
Glucose is an important regulator of cell growth and metabolism. Uridine diphosphate sugars (UDP-sugars), as the intermediate products of metabolism, play pivotal roles as precursors in the synthesis of complex carbohydrates and glycolipids as well as ...
Lu, PZ, Zhang, YK, Xu, GW, Lehmann, R, Liebich, HM, Lu, X   +5 more
core  

Uridine Bisphosphonates Differentiate Phosphoglycosyl Transferase Superfamilies

Complex bacterial glycoconjugates drive interactions between pathogens, symbionts, and their human hosts. Glycoconjugate biosynthesis is initiated at the membrane interface by phosphoglycosyl transferases (PGTs), which catalyze the transfer of a ...
Leah M. Seebald (3852727), Charles E. McKenna (145054), Pouya Haratipour (5420441), Hannah M. Bernstein (17669482), Boris A. Kashemirov (1312626), Barbara Imperiali (758823), Michaela R. Jacobs (17847846)   +6 more
core   +1 more source

Hidden O‐Deglycosylation Activity Triggers O → C Rearrangement for Aryl Di‐C‐Glucoside Formation by the C‐Glycosyltransferase From Fortunella crassifolia

Biotechnology and Bioengineering, Volume 123, Issue 5, Page 1327-1337, May 2026.
Here, we uncovered an unexpected O‐deglycosylation activity of the C glycosyltransferase (FcCGT), forming phloretin (1) from phloretin 2'‐O‐glucoside (2). In the presence of UDP, FcCGT catalyzes the O→C rearrangement to yield nothofagin (3). Upon additional UDP‐glucose, further C‐glycosylation occurs, forming phloretin 3',5'‐di‐C‐glucoside (4 ...
Tuo Li, Annika J. E. Borg, Leo Krammer, Rolf Breinbauer, Bernd Nidetzky   +4 more
wiley   +1 more source

Characterization of PmHS2 glycosyltransferases for the controlled synthesis of heparosan : a precursor of heparin and heparan sulfate

, 2011
Heparin (Hep), a highly sulfated and complex glycosaminoglycan polysaccharides, is worldwide used as an anticoagulant compound to prevent blood clotting during surgery.
Chavaroche, A.A.E.
core