Results 101 to 110 of about 75,327 (314)

213Bi-PAI2 conjugate selectively induces apoptosis in PC3 metastatic prostate cancer cell line and shows anti-cancer activity in a xenograft animal model [PDF]

A novel α-particle emitting (213Bi) plasminogen activator inhibitor type 2 construct, which targets the membrane-bound urokinase plasminogen activator on prostate cancer cells, was prepared and evaluated in vitro and in a xenograft animal model.
B J Allen, BJ Allen, BJ Allen, BJ Allen, C Festuccia, CP Evans, CW Crowley, EKO Kruithof, IR Radford, J Pollanen, JF Ward, JG Jurcic, M Gleave, M Ranson, M Ranson, M Schmitt, MR McDevitt, MR McDevitt, MTN Hang, P Workman, PA Andreasen, R Greenlee, RK Jain, RM Macklis, S M A Rizvi, SJ Kennel, SMA Rizvi, TK Nikula, Y Gavrieli, Y Li, Y Li   +30 more
core   +2 more sources

The Receptor for Urokinase-type Plasminogen Activator is Expressed by Keratinocytes at the Leading Edge During Re-Epithelialization of Mouse Skin Wounds [PDF]

, 1994
Expression of urokinase-type plasminogen activator receptor mRNA was examined in vivo in mouse skin wounds by in situ hybridization. Urokinase-type plasminogen activator receptor mRNA was found in keratinocytes at the front of the regenerative epithelial
Danø, Keld, Eriksen, Jens, Kristensen, Peter, Lund, Leif R, Pyke, Charles, Rømer, John   +5 more
core   +1 more source

Urokinase-type plasminogen activator in carcinomatous pleural fluid [PDF]

European Respiratory Journal, 1997
Urokinase-type plasminogen activator (u-PA) is known to be secreted by malignant cells during proliferation and migration, and is associated with tumour cell invasion and metastasis. This study was undertaken to evaluate whether u-PA is significantly increased in carcinomatous pleural fluids compared to those due to other aetiologies, and to identify ...
Yuko T. Yamashita, Takashi Naito, Shizuo Hasegawa, Takuya Yazawa, Takesaburo Ogata, Hiroaki Satoh, Hiroichi Ishikawa, Hiroshi Kamma, Morio Ohtsuka   +8 more
openaire   +3 more sources

Ultrastructural localization of plasma membrane-associated urokinase- type plasminogen activator at focal contacts

Journal of Cell Biology, 1988
We have recently shown that urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor type 1 are both found extracellularly beneath cultured human skin fibroblasts and HT-1080 sarcoma cells, but in distinct localizations.
Jari P, Inen, K. Hedman, L. Nielsen, K. Dan, A. Vaheri   +5 more
semanticscholar   +1 more source

Micro‐ and nanomotors in biomedical applications

Responsive Materials, EarlyView.
Micro‐ and nanomotors (MNMs), as autonomous devices converting chemical or external energy into mechanical propulsion, have emerged as transformative drug delivery platforms in biomedicine. This review systematically outlines the design principles governing MNMs' propulsion and operation, highlights the applications of MNMs in disease treatment, and ...
Xiangyu Meng, Yuqi Tang, Quan Li
wiley   +1 more source

E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects

JCI Insight, 2021
Fibroproliferative disorders such as systemic sclerosis (SSc) have no effective therapies and result in significant morbidity and mortality. We recently demonstrated that the C-terminal domain of endostatin, known as E4, prevented and reversed both ...
Shailza Sharma, Tomoya Watanabe, Tetsuya Nishimoto, Takahisa Takihara, Logan Mlakar, Xinh-Xinh Nguyen, Matthew Sanderson, Yunyun Su, Roger A. Chambers, Carol Feghali-Bostwick   +9 more
doaj   +1 more source

Cytotoxicity of the urokinase-plasminogen activator inhibitor carbamimidothioic acid (4-boronophenyl) methyl ester hydrobromide (BC-11) on triple-negative MDA-MB231 breast cancer cells [PDF]

, 2015
: BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal ...
Baltus, Christine B, Chuckowree, Irina S, Librizzi, Mariangela, Longo, Alessandra, Luparello, Claudio, Spencer, John   +5 more
core   +2 more sources

Quercetin Reduces Vascular Senescence and Inflammation in Symptomatic Male but Not Female Coronary Artery Disease Patients

Aging Cell, EarlyView.
In male patients undergoing CABG surgery, pretreatment with quercetin suppressed inflammaging and its associated inflammation, leading to improved endothelium‐dependent relaxation (measured ex vivo) and reducing new onset of post‐operative atrial fibrillation.
Pauline Mury, Olina Dagher, Annik Fortier, Ariel Diaz, Yoan Lamarche, Pierre‐Emmanuel Noly, Marina Ibrahim, Pierre Pagé, Philippe Demers, Denis Bouchard, Pierre‐Luc Bernier, Nancy Poirier, Emmanuel Moss, Nicolas Durrleman, Hughes Jeanmart, Michel Pellerin, Guillaume Lettre, Nathalie Thorin‐Trescases, Michel Carrier, Eric Thorin   +19 more
wiley   +1 more source

Roles and regulation of membrane-associated serine proteases [PDF]

, 2007
Pericellular proteolytic activity affects many aspects of cellular behaviour, via mechanisms involving processing of the extracellular matrix, growth factors and receptors.
Bass, Rosemary, Ellis, V, Gray, Kelly, Owen, K, Qiu, Deyi   +4 more
core   +1 more source

Pro-urokinase-type Plasminogen Activator Is a Substrate for Hepsin [PDF]

Journal of Biological Chemistry, 2006
Hepsin, a type II transmembrane serine protease, is strongly up-regulated in prostate cancer. Hepsin overexpression in a mouse prostate cancer model resulted in tumor progression and metastasis, associated with basement membrane disorganization. We investigated whether hepsin enzymatic activity was linked to the basement membrane defects by examining ...
Wei Li, Bin Fan, Charles Eigenbrot, Daniel Kirchhofer, Paul Moran, Rajesh Vij   +5 more
openaire   +2 more sources