Results 111 to 120 of about 75,327 (314)

Rac Mediates Cytoskeletal Rearrangements and Increased Cell Motility Induced by Urokinase-Type Plasminogen Activator Receptor Binding to Vitronectin

Journal of Cell Biology, 2001
The urokinase-type plasminogen activator receptor (uPAR) is involved in the regulation of cell motility in a variety of cell types. We show here that expression of human uPAR in growing murine fibroblasts leads to a dramatic reorganization of the actin ...
L. Kjøller, A. Hall
semanticscholar   +1 more source

Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Periodontitis: A Case–Control Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Introduction The plasminogen activating (PA) system has a multitude of functions such as wound healing, proteolytic activity, collagen degradation and cell growth, and the role of the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system has been studied in many disease states.
Ahmed Khudhur, Christopher Dowson, Susan M. Bissett, Rachel van de Merwe, John J. Taylor, Philip M. Preshaw, Katrin M. Jaedicke   +6 more
wiley   +1 more source

Molecular mechanism of action of newer thrombolytic agents [PDF]

, 1987
Recombinant tissue-type plasminogen activator (rt-PA) and single chain urokinase-type plasminogen activator (scu-PA) are thrombolytic agents, characterized by a high but not absolute degree of fibrin specificity that is mediated through different ...
Collen, Desire
core   +1 more source

Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells

Journal of Cell Biology, 1987
Cellular migration is an essential component of invasive biological processes, many of which have been correlated with an increase in plasminogen activator production.
M. Pepper, J. Vassalli, R. Montesano, L. Orci   +3 more
semanticscholar   +1 more source

Effect of Plasma Soluble Urokinase-Type Plasminogen Activator Receptor and Plasminogen Activator Inhibitor-1 Levels in the Plasma of Babylon Women with Breast Cancer

Medical Journal of Babylon
Background: Worldwide, the occurrence of breast cancer is elevated as well as the number of mortality in women cancers. The movement of cancer cells from the first stage and invasion of the surrounding tissue are called cancer metastasis.
Sheerin H. Abbas, Zinah Abbass Ali, Alaa Sadiq Alaawad   +2 more
doaj   +1 more source

The Tissue Fibrinolytic System Contributes to the Induction of Macrophage Function and CCL3 during Bone Repair in Mice. [PDF]

PLoS ONE, 2015
Macrophages play crucial roles in repair process of various tissues. However, the details in the role of macrophages during bone repair still remains unknown.
Naoyuki Kawao, Yukinori Tamura, Yoshitaka Horiuchi, Katsumi Okumoto, Masato Yano, Kiyotaka Okada, Osamu Matsuo, Hiroshi Kaji   +7 more
doaj   +1 more source

Recent advances in cardiovascular medicines : thrombolytics [PDF]

, 1990
Thrombolytic therapy represents a major advance in reducing mortality following myocardial infarction. Pharmacists must be aware of the principles and problems of thrombolysis and the extant large studies conducted in hospitals and in the community. This
Felice, Herbert, Gatt, Marise, Harron, Dean   +2 more
core  

Urokinase-Type Plasminogen Activator Promotes Paracellular Transmigration of Neutrophils Via Mac-1, But Independently of Urokinase-Type Plasminogen Activator Receptor [PDF]

Circulation, 2011
Background— Urokinase-type plasminogen activator (uPA) has recently been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury. The underlying mechanisms remain largely unclear. Methods and Results— Using in vivo microscopy on the mouse cremaster muscle, I/R-elicited ...
Reichel, Christoph A., Uhl, Bernd, Lerchenberger, Max, Puhr-Westerheide, Daniel, Rehberg, Markus, Liebl, Johanna, Khandoga, Andrej, Schmalix, Wolfgang, Zahler, Stefan, Deindl, Elisabeth, Lorenzl, Stefan, Declerck, Paul J., Kanse, Sandip, Krombach, Fritz   +13 more
openaire   +4 more sources

Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells

Journal of Cell Biology, 1987
We studied the immunocytochemical localization of urokinase-type plasminogen activator (u-PA) and the type 1 plasminogen activator inhibitor (PAI-1) in human fibroblasts and sarcoma cells, using both polyclonal and monoclonal antibodies.
J. Pöllänen, O. Saksela, E. Salonen, P. Andreasen, L. Nielsen, K. Danø, A. Vaheri   +6 more
semanticscholar   +1 more source

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, Volume 12, Issue 25, July 3, 2025.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source