Results 101 to 110 of about 6,870,828 (229)

Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor Induction by Etoposide in a Glioblastoma Cell Strain

Food Technology and Biotechnology, 2002
Urokinase plasminogen activator (uPA) and its inhibitors (PAI) are elements of plasminogen activation system, a proteolytic system involved in many physiological and patological processes.
Branko Brdar, Maja Matulić
doaj  

Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator

Scientific Reports, 2017
Although trypsin-like serine proteases have flexible surface-exposed loops and are known to adopt higher and lower activity conformations, structural determinants for the different conformations have remained largely obscure.
Tobias Kromann-Hansen, Eva Louise Lange, Hans Peter Sørensen, Gholamreza Hassanzadeh-Ghassabeh, Mingdong Huang, Jan K. Jensen, Serge Muyldermans, Paul J. Declerck, Elizabeth A. Komives, Peter A. Andreasen   +9 more
doaj   +1 more source

Dynamic Remodeling of Oocyte‐Granulosa Cell Communication During Bovine Folliculogenesis Revealed by Transcriptomic Meta‐Analyses

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Bidirectional communication between oocytes and granulosa cells undergoes progressive remodeling during bovine folliculogenesis. Integrative transcriptomic analysis identified stage‐specific ligand‐receptor signaling networks coordinating structural, metabolic, and developmental processes.
Noemi Monferini, Ludovica Donadini, Pritha Dey, Federica Franciosi, Valentina Lodde, Maria Belen Rabaglino, Alberto Maria Luciano   +6 more
wiley   +1 more source

Plasma Soluble Urokinase Plasminogen Activator Receptor in Children with Urinary Tract Infection

, 2011
Objective In this prospective study we investigated the role of plasma levels of soluble urokinase plasminogen activator receptor (suPAR) in children with urinary tract infection.
Lone Lindholm, Per Wittenhagen, Jesper Brandt Andersen, Jørn Theil, Anita Hansen, Jesper Eugen-Olsen, Frederik Rønne, Michael Tvede   +7 more
core   +1 more source

A Narrative Review on Abnormalities in the Hemostatic System in Diabetes Mellitus: Pathophysiology, Clinical Implications, and Therapeutics

Life
Diabetes mellitus (DM) is a complex metabolic disorder associated with a heightened risk of cardiovascular events, largely driven by a hypercoagulable and hypofibrinolytic state.
Sana Rafaqat, Hafsa Hamid, Fakhra Bashir, Hijab Abaid, Aleksandra Klisic, Saira Rafaqat, Filiz Mercantepe   +6 more
doaj   +1 more source

Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer

Neoplasia: An International Journal for Oncology Research, 2009
Angioinvasion is critical for metastasis with urokinase-type plasminogen activator receptor (uPAR) and tumor hypoxia-activated hypoxia-inducible factor 1 (HIF-1) as key players.
Peter Büchler, Howard A. Reber, James S. Tomlinson, Oliver Hankinson, Georgis Kallifatidis, Helmut Friess, Ingrid Herr, Oscar J. Hines   +7 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Urokinase-type plasminogen activator receptor

, 2003
A polypeptide presenting an epitope cross-reactive with an epitope of urokinase-type plasminogen activator receptor, and/or having uPA binding activity, is described.
Pollanen,, Jari, Vaheri,, Antti, Dano, Keld, Pyke, Charles, Masucci, Maria, Teresa, Roldan, Ann, Louring, Behrendt, Niels, Ploug, Michael, Cubellis, Maria, Vittoria, Ronne, Ebbe, Tapiovaara,, Hannele, Lund Leif, Roge, Patthy, Laszlo, Salonen,, Eeva-Marjatta, Moller Lisbeth, Birk, Ellis, Vincent, Stephens, Ross, W, Blasi, Francesco, Appella,, Ettore, Schleuning,, Wolf-Dieter, Kristensen, Peter   +20 more
core   +1 more source

Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancements

Frontiers in Molecular Biosciences
Serine protease inhibitors (serpins) are the most numerous and widespread multifunctional protease inhibitor superfamily and are expressed by all eukaryotes.
Shutong Wu, Shutong Wu, Yuchao Yang, Yuchao Yang, Meiling Zhang, Asmat Ullah Khan, Jingxing Dai, Jun Ouyang   +7 more
doaj   +1 more source

Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer

BMC Cancer, 2006
Background Matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and urokinase-type plasminogen activator (uPA) are involved in colorectal cancer invasion and metastasis.
Lim Kyu, Park Hae-Duck, Choi Hoon, Li Ge, Song Kyoung-Sub, Kim Tae-Dong, Hwang Byung-Doo, Yoon Wan-Hee   +7 more
doaj   +1 more source