Results 101 to 110 of about 7,182,421 (220)

A Narrative Review on Abnormalities in the Hemostatic System in Diabetes Mellitus: Pathophysiology, Clinical Implications, and Therapeutics

Life
Diabetes mellitus (DM) is a complex metabolic disorder associated with a heightened risk of cardiovascular events, largely driven by a hypercoagulable and hypofibrinolytic state.
Sana Rafaqat, Hafsa Hamid, Fakhra Bashir, Hijab Abaid, Aleksandra Klisic, Saira Rafaqat, Filiz Mercantepe   +6 more
doaj   +1 more source

Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer

Neoplasia: An International Journal for Oncology Research, 2009
Angioinvasion is critical for metastasis with urokinase-type plasminogen activator receptor (uPAR) and tumor hypoxia-activated hypoxia-inducible factor 1 (HIF-1) as key players.
Peter Büchler, Howard A. Reber, James S. Tomlinson, Oliver Hankinson, Georgis Kallifatidis, Helmut Friess, Ingrid Herr, Oscar J. Hines   +7 more
doaj   +1 more source

Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancements

Frontiers in Molecular Biosciences
Serine protease inhibitors (serpins) are the most numerous and widespread multifunctional protease inhibitor superfamily and are expressed by all eukaryotes.
Shutong Wu, Shutong Wu, Yuchao Yang, Yuchao Yang, Meiling Zhang, Asmat Ullah Khan, Jingxing Dai, Jun Ouyang   +7 more
doaj   +1 more source

Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer

BMC Cancer, 2006
Background Matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and urokinase-type plasminogen activator (uPA) are involved in colorectal cancer invasion and metastasis.
Lim Kyu, Park Hae-Duck, Choi Hoon, Li Ge, Song Kyoung-Sub, Kim Tae-Dong, Hwang Byung-Doo, Yoon Wan-Hee   +7 more
doaj   +1 more source

Soluble urokinase-type plasminogen activator receptor as a prognostic biomarker in critically ill patients.

, 2014
The aim of this study was to assess the role of blood soluble urokinase-type plasminogen activator receptor (suPAR) levels in the diagnosis and prognostication of sepsis in critically ill patients.Journal ArticleSCOPUS: ar.jinfo:eu-repo/semantics ...
Scolletta, Sabino, Taccone, Fabio Silvio, Santonocito, Cristina, Cortés, Diego Orbegozo, Vincent, Jean-Louis, Vincent, Jean Louis, Covajes, Cecilia, Taccone, Fabio, Gottin, Leonardo, Grazulyte, Daiva, Donadello, Katia, Scolletta S, Santonocito C, Cortes DO, Grazulyte D, Covajes C, Vincent JL, Taccone FS, Cortes D. O., Grazulyte D., Covajes C., Taccone F. S., Santonocito C., Donadello K., Vincent J. -L., Gottin L., Scolletta S.   +26 more
core   +1 more source

The murine urokinase-type plasminogen activator receptor gene

Journal of Biological Chemistry, 1994
The murine urokinase-type plasminogen activator receptor (uPAR) gene has been isolated and its complete nucleotide sequence established. The gene is organized into seven exons comprising 9.5% of the 13,207-base pair region that spans the interval between the transcription initiation and polyadenylation sites.
T T, Suh, C, Nerlov, K, Danø, J L, Degen   +3 more
openaire   +2 more sources

Host urokinase-type plasminogen activator participates in the release of malaria merozoites from infected erythrocytes

, 1997
International audienceMalaria infection of red blood cells is associated with plasminogen activation. Surface immunofluorescence and immunoprecipitation experiments, using specific polyclonal and monoclonal antibodies raised against human urokinase ...
Catherine Braun-Breton, Roggwiller, Emmanuelle, Emmanuelle Roggwiller, Fricaud, Anne-Catherine, Anne-Catherine Fricaud, Braun-Breton, Catherine, Thierry Blisnick, Blisnick, Thierry   +7 more
core   +1 more source

Causal association of plasminogen activators and their inhibitors with Alzheimer’s disease: a Mendelian randomization study

Archives of Medical Science
Introduction Alzheimer’s disease (AD) is the most common cause of dementia and contributes to a huge burden of disease worldwide. Observational studies have found that tissue plasminogen activator (t-PA) inhibits the development of AD, but little is ...
Xin Guo, Fangyu Gao, Baolong Pan, Feng Gao, Jingsi Zhang, Shanshan Wang, Qiao Niu   +6 more
doaj   +1 more source

Abstract 17717: Association of Depression with Soluble Urokinase- Type Plasminogen Activator Receptor and Other Markers of Inflammation and Immunity

, 2012
Background: Depression, coronary artery disease (CAD), and inflammation may share pathophysiological links. Soluble urokinase-type plasminogen activator receptor (suPAR) is a biomarker of inflammat..
Al Kassem, Hatem, Ghasemzadeh, Nima, Vaccarino, Viola, Manocha, Pankaj, Kumar, Saket, Shah, Amit J., Thorball, Christian W., Sher, Salman, Hammadah, Muhammad, Garcia-Bengochea, Youssef O, Niaz, Adil, Patel, Riyaz S., Syed, Hamid, Veledar, Emir, Tahhan, Ayman Samman, Eapen, Danny J., Kelli, Heval M., Farook, Naureen, Le, Ngoc-Anh, Pimple, Pratik, Nanjundappa, Ravi, Obideen, Malik, Quyyumi, Arshed A., Kabani, Sarah S, Raison, Charles L, Zafari, Rostam, Sperling, Laurence S., Pielak, Tomasz   +27 more
core   +1 more source

Video Description from Structure-based design of an urokinase-type plasminogen activator receptor–derived peptide inhibiting cell migration and lung metastasis

, 2009
Video Description from Structure-based design of an urokinase-type plasminogen activator receptor–derived peptide inhibiting cell migration and lung ...
Mario De Rosa (15040481), Liliana Lista (2709868), Giuseppina Votta (2141533), Maria Vincenza Carriero (8713431), Renato Franco (184143), Maria Teresa Masucci (15040478), Maria Patrizia Stoppelli (133653), Katia Bifulco (133627), Vincenzo Pavone (133641), Claudio Arra (133331), Antonio Barbieri (458558), Immacolata Longanesi-Cattani (133632), Ornella Maglio (4379920)   +12 more
core   +1 more source