Results 121 to 130 of about 75,327 (314)

Functional Stability of Plasminogen Activator Inhibitor-1

The Scientific World Journal, 2014
Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of plasminogen activators, such as tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), and a major regulator of the fibrinolytic system.
Songul Yasar Yildiz, Pinar Kuru, Ebru Toksoy Oner, Mehmet Agirbasli   +3 more
doaj   +1 more source

immunocytochemical localization of urokinase-type plasminogen activator in lewis lung carcinoma

Journal of Cell Biology, 1984
The invasively growing and metasizing Lewis lung carcinoma consistently contained urokinase-type plasminogen activator (u-PA) enzyme activity. When investigated immunocytochemically with antibodies against u-PA, different parts of individual tumors ...
L. Skriver, LI Larsson, V. Kielberg, L. Nielsen, PB Andresen, P. Kristensen, K. Danø   +6 more
semanticscholar   +1 more source

Obesity Biomarkers: Exploring Factors, Ramification, Machine Learning, and AI‐Unveiling Insights in Health Research

MedComm, Volume 6, Issue 7, July 2025.
The graphical abstract emphasizes the complex nature of obesity, focusing on the interaction of behavioral, sociodemographic, genetic, and biomarker factors. It illustrates how lifestyle habits, demographics, and genetic predispositions influence obesity risk.
Ankita Awari, Deepika Kaushik, Ashwani Kumar, Emel Oz, Kenan Çadırcı, Charles Brennan, Charalampos Proestos, Mukul Kumar, Fatih Oz   +8 more
wiley   +1 more source

Interdependence of kallikrein-related peptidases in proteolytic networks [PDF]

, 2010
Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short propeptide. We searched for
Debela, Emami, Freije, Frenette, Gomis, Hollenberg, Itoh, Jung, Lopez, Ohler, Pampalakis, Ramsay, Ries, Rittenhouse, Ryu, Shaw, Sperl, Takayama, Takayama, Tye, Yoon, Yoon   +21 more
core   +1 more source

The NLRP3 inhibitor NT‐0796 enhances and sustains GLP‐1R agonist‐mediated weight loss in a murine diet‐induced obesity model

Obesity, Volume 33, Issue 7, Page 1309-1321, July 2025.
In mouse diet‐induced obesity models, the brain penetrant NLRP3 inhibitor NT‐0796 enhances and sustains the efficacy of the GLP‐1RA semaglutide, leading to a complete reversal of obesity. This correlates with reduced peripheral inflammation and anti‐neuroinflammatory activities, including a reduction in hypothalamic gliosis suggesting further benefits ...
Peter Thornton, Valérie Reader, Zsofia Digby, John Doedens, Nicola Lindsay, Nicholas Clarke, Alan P. Watt   +6 more
wiley   +1 more source

Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator

Scientific Reports, 2017
Although trypsin-like serine proteases have flexible surface-exposed loops and are known to adopt higher and lower activity conformations, structural determinants for the different conformations have remained largely obscure.
Tobias Kromann-Hansen, Eva Louise Lange, Hans Peter Sørensen, Gholamreza Hassanzadeh-Ghassabeh, Mingdong Huang, Jan K. Jensen, Serge Muyldermans, Paul J. Declerck, Elizabeth A. Komives, Peter A. Andreasen   +9 more
doaj   +1 more source

SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer [PDF]

, 2017
Pancreatic cancer has a devastating prognosis, with an overall 5-year survival rate of ~8%, restricted treatment options and characteristic molecular heterogeneity.
A H Allam, A Neesse, A Neesse, A V Biankin, A Xue, AB Seymour, AD Rhim, AK Witkiewicz, AM LeBeau, AR Shekouh, AV Biankin, B Hinz, BC Ozdemir, BJ Cochran, BJ Cochran, C Gaggioli, C Vennin, D Croucher, D Goldstein, D Herrmann, D Herrmann, D Mahadevan, D N Saunders, D Telgenhoff, DD Von Hoff, DR Croucher, DR Croucher, E Cerami, F Al-Ejeh, G Finak, H Shiomi, HW Smith, I Garrido-Laguna, J Condeelis, J Gao, J Gore, J Lee, J Li, J P Morton, J R W Conway, JA Lee, JJ Lee, JP Morton, K Kessenbrock, K L Vine, L Harris, M C Lucas, M J Cowley, M Nobis, M Pajic, M Pinese, M Ranson, MJ Duffy, ML Nyström, N L E Harris, N Waddell, P Bailey, P Carmeliet, P Timpson, P Timpson, R Cicchi, R F Shearer, R Kalluri, R Smith, RF Shearer, RG Rowe, RL Siegel, S Nurmenniemi, S Ulisse, SC Barry, SR Hingorani, SR Hingorani, TK Stutchbury, WA Schroder, Y Takeuchi, ZS Boyd, Ö Babur   +76 more
core   +1 more source

Near‐Infrared Fluorescent Single‐Walled Carbon Nanotubes for Biosensing

Small, Volume 21, Issue 26, July 3, 2025.
Near‐infrared fluorescent single‐walled carbon nanotubes (SWCNTs) stand out as versatile biosensors due to their spectral overlap with the biological transparency window, surface‐sensitive fluorescence emission, and chemical modularity. This review offers a concise guide to understanding the photophysics of SWCNTs, various functionalization strategies,
Srestha Basu, Gili Bisker
wiley   +1 more source

Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes [PDF]

, 2012
mRNA levels of the urokinase receptor splice variant uPAR-del4/5 are associated with prognosis in breast cancer. Its overexpression in cancer cells affects tumor biologically relevant processes.
Baretton, Gustavo, Grismayer, Bettina, Kopitz, Charlotte, Kotzsch, Matthias, Krueger, Achim, Luther, Thomas, Magdolen, Viktor, Ries, Christian, Sato, Sumito, Schmitt, Manfred, Soelch, Susanne   +10 more
core   +1 more source

The murine urokinase-type plasminogen activator receptor gene

Journal of Biological Chemistry, 1994
The murine urokinase-type plasminogen activator receptor (uPAR) gene has been isolated and its complete nucleotide sequence established. The gene is organized into seven exons comprising 9.5% of the 13,207-base pair region that spans the interval between the transcription initiation and polyadenylation sites.
Claus Nerlov, Keld Danø, Jay L. Degen, Theodore T. Suh   +3 more
openaire   +3 more sources