Results 131 to 140 of about 75,327 (314)

Crystal structure of coagulation factor XII N‐terminal domains 1–5

Acta Crystallographica Section D, Volume 81, Issue 7, Page 380-393, July 2025.
Factor XII (FXII) is a plasma serine protease which becomes activated by interactions with polyanions such as polyphosphates from bacteria, with Zn2+ as a critical cofactor. The crystal structure of FXII domains 1–5, coupled with a second crystal structure of the isolated FnII domain in complex with Zn2+ ions, advances our understanding of FXII ...
Muhammad Saleem, Chan Li, Bubacarr G. Kaira, Alexander K. Brown, Monika Pathak, Shabir Najmudin, Nathan Cowieson, Ingrid Dreveny, Clare Wilson, Aleksandr Shamanaev, David Gailani, Stephanie A. Smith, James H. Morrissey, Helen Philippou, Jonas Emsley   +14 more
wiley   +1 more source

Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer

Neoplasia: An International Journal for Oncology Research, 2009
Angioinvasion is critical for metastasis with urokinase-type plasminogen activator receptor (uPAR) and tumor hypoxia-activated hypoxia-inducible factor 1 (HIF-1) as key players.
Peter Büchler, Howard A. Reber, James S. Tomlinson, Oliver Hankinson, Georgis Kallifatidis, Helmut Friess, Ingrid Herr, Oscar J. Hines   +7 more
doaj   +1 more source

Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling. [PDF]

, 2015
In glioblastoma (GBM), the EGF receptor (EGFR) and Src family kinases (SFKs) contribute to an aggressive phenotype. EGFR may be targeted therapeutically; however, resistance to EGFR-targeting drugs such as Erlotinib and Gefitinib develops quickly.
Cavenee, WK, Furnari, FB, Gonias, SL, Hu, J, Muller, KA, VandenBerg, SR   +5 more
core  

A network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure [PDF]

, 2019
Aims Heart failure (HF) is frequently caused by an ischaemic event (e.g. myocardial infarction) but might also be caused by a primary disease of the myocardium (cardiomyopathy).
Anker, Stefan D., Cleland, John G. F., Dickstein, Kenneth, Hillege, Hans L., Lam, Carolyn S. P., Lang, Chim C., Metra, Marco, Nauta, Jan F., Ng, Leong L., Romaine, Simon P. R., Sama, Iziah E., Samani, Nilesh J., Ter Maaten, Jozine M., Tromp, Jasper, van der Meer, Peter, van Veldhuisen, Dirk J., Voors, Adriaan A., Woolley, Rebecca J., Zannad, Faiez   +18 more
core   +5 more sources

Identification of a Novel Mutation in the SERPINE1 Gene Causing Clinical Hyperfibrinolysis in English Springer Spaniel Dogs

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Background A 7‐month‐old female spayed English Springer Spaniel (ESS) was evaluated for spontaneous hemoperitoneum. Hyperfibrinolysis was identified on thromboelastography. Hypothesis/Objectives To identify a genetic mutation causing congenital hyperfibrinolysis in the proband and evaluate the prevalence of the mutation in the ESS breed ...
Kelley Kilpatrick, Jonah N. Cullen, Farah F. Almeer, LeeAnn Higgins, Todd Markowski, Marjory Brooks, Steven G. Friedenberg, Molly Racette   +7 more
wiley   +1 more source

Association between serum soluble urokinase-type plasminogen activator receptor and atrial fibrillation

Journal of Arrhythmia, 2017
Background: Circulating soluble urokinase-type plasminogen activator receptor (suPAR), which can reflect immune activation and low-grade inflammation, may be a novel biomarker of cardiovascular disease.
Noboru Ichihara, Masatoshi Miyamura, Daichi Maeda, Tomohiro Fujisaka, Shu-ichi Fujita, Hideaki Morita, Yoshihiro Takeda, Takahide Ito, Koichi Sohmiya, Masaaki Hoshiga, Nobukazu Ishizaka   +10 more
doaj   +1 more source

Coagulation and anticoagulation in idiopathic pulmonary fibrosis [PDF]

, 2015
Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events.
Crooks, Michael G., Hart, Simon P.
core   +3 more sources

Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase-type plasminogen activator.

Blood, 2001
The Quebec platelet disorder (QPD) is an autosomal dominant platelet disorder associated with delayed bleeding and alpha-granule protein degradation.
W. Kahr, Shilun Zheng, P. Sheth, Menaka Pai, A. Cowie, Madeleine Bouchard, Thomas J. Podor, G. Rivard, Catherine P. M. Hayward   +8 more
semanticscholar   +1 more source

Prognostic Value of the TLM3 Biomarker Panel for Early Fibrosis Development in MASLD Within the General Population

Liver International, Volume 45, Issue 7, July 2025.
ABSTRACT Background & Aims Fibrotic MASLD is associated with increased morbidity and mortality, often remaining asymptomatic until advanced stages of disease. Predicting fibrosis onset and progression would improve risk stratification and treatment allocation.
Koen C. van Son, Jelle C. B. C. de Jong, Serdar Özsezen, Martien P. M. Caspers, Quinten J. J. Augustijn, Jessica Snabel, Henrike Galenkamp, Henrike M. Hamer, Anne‐Marieke van Dijk, Arianne van Koppen, Anne Linde Mak, Bert‐Jan van den Born, Max Nieuwdorp, Joost P. H. Drenth, Lise Lotte Gluud, Maarten E. Tushuizen, Roeland Hanemaaijer, Lars Verschuren, Adriaan G. Holleboom   +18 more
wiley   +1 more source

Involvement of Urokinase-Type Plasminogen Activator in Acantholysis Induced by Pemphigus IgG [PDF]

, 1987
Pemphigus IgG induces acantholysis in skin organ culture without the involvement of complement. Urokinase-type plasminogen activator, a proteolytic enzyme, has been implicated in the development of acantholysis.
Jensen, Pamela J., Lazarus, Gerald S., Morioka, Shinji   +2 more
core   +1 more source