Results 131 to 140 of about 48,370 (295)

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancements

Frontiers in Molecular Biosciences
Serine protease inhibitors (serpins) are the most numerous and widespread multifunctional protease inhibitor superfamily and are expressed by all eukaryotes.
Shutong Wu, Shutong Wu, Yuchao Yang, Yuchao Yang, Meiling Zhang, Asmat Ullah Khan, Jingxing Dai, Jun Ouyang   +7 more
doaj   +1 more source

SP235SOLUBLE UROKINASE TYPE PLASMINOGEN ACTIVATOR RECEPTOR AS A PREDICTOR OF CHRONIC KIDNEY DISEASE [PDF]

, 2016
Ana Carina Ferreira, Miguel Verdelho, Maria Céu Santos, Fernando Nolasco   +3 more
openalex   +1 more source

Isoquercetin and Zafirlukast Cooperatively Suppress Tumor Growth and Thromboinflammatory Signaling in a Xenograft Model of Ovarian Cancer

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Treatment using either the thiol isomerase inhibitor isoquercetin or zafirlukast lowers tissue factor levels, decreases VEGF, inhibits PD‐L1, and TMEM176B in a xenograft model of ovarian cancer. A combination of the two agents, at threefold lower concentrations than either drug, significantly enhanced the inhibition further, suggesting a dual action of
Justine A. Keovilay, Jason W. Hoskins, Jean‐Pierre Kinet, Thomas C. Lines, Daniel R. Kennedy   +4 more
wiley   +1 more source

Association between serum soluble urokinase-type plasminogen activator receptor and atrial fibrillation

Journal of Arrhythmia, 2017
Background: Circulating soluble urokinase-type plasminogen activator receptor (suPAR), which can reflect immune activation and low-grade inflammation, may be a novel biomarker of cardiovascular disease.
Noboru Ichihara, Masatoshi Miyamura, Daichi Maeda, Tomohiro Fujisaka, Shu-ichi Fujita, Hideaki Morita, Yoshihiro Takeda, Takahide Ito, Koichi Sohmiya, Masaaki Hoshiga, Nobukazu Ishizaka   +10 more
doaj   +1 more source

Astrocyte–vascular interplay in Alzheimer's disease pathology: Novel insights into stage‐specific biomarkers and therapeutic targets

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION We examined how neurovascular and astrocytic response alter cognition in Alzheimer's disease (AD). METHODS Cognitive scores, biomarkers of AD and astrocytic activation, vascular factors, and brain structure data from 693 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants were analyzed using analysis of covariance ...
Zehu Sheng, Yuhao Chen, Ming Chen, Shuyu Liang, Jingyi Wang, Yingxi Chen, Rengui Li, Boyuan Xia, Kangjinyuan Gou, Siyuan Liu, Alzheimer's Disease Neuroimaging Initiative, Weihua Yu, Yang Lü   +12 more
wiley   +1 more source

Coordinated expression of vascular endothelial growth factor A and urokinase-type plasminogen activator contributes to classical swine fever virus Shimen infection in macrophages

BMC Veterinary Research, 2019
Background The Shimen strain of classical swine fever (CSF) virus (CSFV) causes CSF, which is mainly characterised by disseminated intravascular haemorrhage.
Xiaocheng Gong, Aoxue Hu, Xuepeng Li, Jun He, Zhongxing Wu, Xi Zuo, Pengbo Ning   +6 more
doaj   +1 more source

Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management

ChemBioChem, Volume 27, Issue 1, January 2026.
Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh, Rupesh R. Kurhade, Abrar A. M. Siddiqui, Shaikh Shahbaz A. Majeed, Thomas J. Webster, Mohammad Intakhab Alam, Abdul Wasy Zia, Md. Faiyazuddin   +7 more
wiley   +1 more source

ヒトPRE-Bリンパ腫細胞株RC-K8におけるBeraprost(a stable analogue of prostacyclin)によるuPA産生抑制効果 [PDF]

, 1996
Plasminogen activation by urokinase-type plasminogen activator (uPA) is implicated in tumor invasion and metastasis by the breakdown of extracellular matrix.We have recently demonstrated the inhibitory effect of cAMP on uPA gene transcription in RC-K8 ...
Nomura Naoki
core   +1 more source

Dattabase Information from Structure-based design of an urokinase-type plasminogen activator receptor–derived peptide inhibiting cell migration and lung metastasis [PDF]

, 2023
Maria Vincenza Carriero, Immacolata Longanesi-Cattani, Katia Bifulco, Ornella Maglio, Liliana Lista, Antônio Barbieri, Giuseppina Votta, Maria Teresa Masucci, Claudio Arra, Renato Franco, Mario De Rosa, Maria Patrizia Stoppelli, Vincenzo Pavone   +12 more
openalex   +1 more source