Results 141 to 150 of about 48,370 (295)

Bevacizumab in ovarian cancer: Clinical data and predictive and prognostic biomarkers

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Evidence supporting bevacizumab in ovarian cancer and predictive biomarkers: highlighting opportunities to improve patient selection and advance personalised treatment strategies. Abstract Angiogenesis, driven by the vascular endothelial growth factor (VEGF)/VEGFR signalling axis under hypoxic conditions, is one of the hallmarks of ovarian cancer (OC),
Maria Rosaria Lamia, Erica Perri, Gustavo Baldassarre, Sandro Pignata, Chiara D'Alessio, Davide Limongello, Francesca Basso‐Valentina   +6 more
wiley   +1 more source

Causal association of plasminogen activators and their inhibitors with Alzheimer’s disease: a Mendelian randomization study

Archives of Medical Science
Introduction Alzheimer’s disease (AD) is the most common cause of dementia and contributes to a huge burden of disease worldwide. Observational studies have found that tissue plasminogen activator (t-PA) inhibits the development of AD, but little is ...
Xin Guo, Fangyu Gao, Baolong Pan, Feng Gao, Jingsi Zhang, Shanshan Wang, Qiao Niu   +6 more
doaj   +1 more source

Exploiting Lactic Acid Bacteria for Regulating Autophagy to Improve Health in Foods and Supplements: A Recent Update

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Lactic acid bacteria (LAB) are frequently used as health supplements. They enhance digestion, regulate immunity, improve gut microbiota, and prevent and manage diseases. Autophagy has a crucial role in the prevention and treatment of tumors, cardiovascular diseases, and pathogenic infections.
Yang Chen, Fangyi Chen, Mengchen Li, Junfeng Xiao, Yang Mu, Chao Wang, Lusha Xia, Mingye Peng, Mengzhou Zhou   +8 more
wiley   +1 more source

Quantitative Real-Time Reverse Transcription-PCR Assay for Urokinase Plasminogen Activator, Plasminogen Activator Inhibitor Type 1, and Tissue Metalloproteinase Inhibitor Type 1 Gene Expressions in Primary Breast Cancer [PDF]

, 2002
Remedios Castelló, Amparo Estellés, Carlos Vázquez, Cristina Falcó, Francisco España, Sergio Almenar, Carlos Fuster, Justo Aznar   +7 more
openalex   +1 more source

Natural Dietary Compounds Targeting NF‐κB Signaling in Cancer: Implications for Nutrition‐Based Prevention and Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Dysregulation of the nuclear factor kappa B (NF‐κB) signaling pathway is closely associated with inflammation‐driven carcinogenesis, tumor progression and resistance to conventional therapies. Sustained NF‐κB activation enhances malignant cell survival, proliferation and immune evasion by promoting proinflammatory and antiapoptotic gene ...
Maria Sharif, Iqra Mutiullah, Kafila Kausar, Rashid Khan, Muhammad Irfan, Solomon Habtemariam, Khushbukhat Khan, Cristina Quispe, William C. Cho, Javad Sharifi‐Rad, Daniela Calina   +10 more
wiley   +1 more source

The autoactivation of human single-chain urokinase-type plasminogen activator (uPA). [PDF]

J Biol Chem, 2023
Torres-Paris C, Chen Y, Xiao L, Song HJ, Chen P, Komives EA.   +5 more
europepmc   +1 more source

The cJun N-terminal kinase (JNK) signaling pathway mediates induction of urokinase-type plasminogen activator (uPA) by the alkylating agent MNNG [PDF]

, 2000
Maribel Parra, Frederic Lluı́s, Francesc Miralles, Carmé Caelles, Pura Muñoz‐Cánoves   +4 more
openalex   +1 more source

The cAMP-ERK1/2 signaling pathway regulates urokinase-type plasminogen activator-induced bovine granulosa cell proliferation [PDF]

, 2020
Yufen Zhao, Boyang Yu, Xinyu Liu, Jitu Hu, Yanyan Yang, Erge Namei, Bingxue Yang, Yue Bai, Yinghong Qian, Haijun Li   +9 more
openalex   +1 more source

Social Support as a Determinant of Dietary Quality in Community‐Dwelling Older Adults in China

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Diet quality and social support play essential roles in maintaining the health of older adults. However, the relationship between these factors remains uncertain. This study aimed to investigate the association between social support and dietary quality among community‐dwelling older adults in China.
Xiaoyan Zhang, Yuanyuan Yan, Feika Li, Jialin Liu, Fang Wu, Dongsheng Bian   +5 more
wiley   +1 more source

Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients [PDF]

, 2017
Background: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are associated with poor prognosis in breast cancer patients.
Beex, Louk V. A. M., Bendahl, Pär-Ola, Blankenstein, Marinus A., Borstnar, Simona, Broët, Philippe, Brünner, Nils, Christensen, Ib Jarle, Cufer, Tanja, Daver, Alain, Daxenbichler, Günter, Duffy, Michael J., Duggan, Catherine, Eppenberger, Urs, Eppenberger-Castori, Serenella, Fernö, Mårten, Fiets, W. Edward, Foekens, John A., Harbeck, Nadia, Jänicke, Fritz, Kates, Ronald, Klijn, Jan G. M., Kueng, Willy, Lisboa, Björn W., Look, Maxime P., Magdelenat, Henri, Manders, Peggy, Martin, Pierre-Marie, Meijer-van Gelder, Marion E., O'Higgins, Niall, Peyrat, Jean-Philippe, Quillien, Véronique, Ricolleau, Gabriel, Romain, Sylvie, Schmitt, Manfred, Spyratos, Frédérique, Sweep, C. G. J. Fred, Thomssen, Christoph, Ulm, Kurt, van Putten, Wim L. J., Windbichler, Gudrun   +39 more
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