Results 141 to 150 of about 168,509 (312)

Estrogen receptors and extracellular matrix: the critical interplay in cancer development and progression

The FEBS Journal, Volume 292, Issue 7, Page 1558-1572, April 2025.
Breast cancer is a complex disease significantly influenced by estrogen receptors (ERs) and the extracellular matrix (ECM), both of which are critical in shaping tumor behavior. ERα and ERβ modulate cancer progression and therapeutic response with their interactions intricately linked to ECM dynamics.
Sylvia Mangani, Zoi Piperigkou, Nikolaos E. Koletsis, Paraskevi Ioannou, Nikos K. Karamanos   +4 more
wiley   +1 more source

Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor Induction by Etoposide in a Glioblastoma Cell Strain

Food Technology and Biotechnology, 2002
Urokinase plasminogen activator (uPA) and its inhibitors (PAI) are elements of plasminogen activation system, a proteolytic system involved in many physiological and patological processes.
Branko Brdar, Maja Matulić
doaj  

Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancements

Frontiers in Molecular Biosciences
Serine protease inhibitors (serpins) are the most numerous and widespread multifunctional protease inhibitor superfamily and are expressed by all eukaryotes.
Shutong Wu, Shutong Wu, Yuchao Yang, Yuchao Yang, Meiling Zhang, Asmat Ullah Khan, Jingxing Dai, Jun Ouyang   +7 more
doaj   +1 more source

Coordinated expression of vascular endothelial growth factor A and urokinase-type plasminogen activator contributes to classical swine fever virus Shimen infection in macrophages

BMC Veterinary Research, 2019
Background The Shimen strain of classical swine fever (CSF) virus (CSFV) causes CSF, which is mainly characterised by disseminated intravascular haemorrhage.
Xiaocheng Gong, Aoxue Hu, Xuepeng Li, Jun He, Zhongxing Wu, Xi Zuo, Pengbo Ning   +6 more
doaj   +1 more source

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours [PDF]

, 2016
Natural killer (NK) lymphocytes are part of the innate immune system and are important in immune protection against tumourigenesis. NK cells display a broad repertoire of activating and inhibitory cell surface receptors that regulate NK cell activity ...
Filtjens, Jessica, Keirsse, Jiri, Kerre, Tessa, Leclercq, Georges, Plum, Jean, Taghon, Tom, Taveirne, Sylvie, Van Acker, Aline, Van Ammel, Els, Van Ginderachter, Jo A, Vandekerckhove, Bart   +10 more
core   +2 more sources

Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Periodontitis: A Case–Control Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Introduction The plasminogen activating (PA) system has a multitude of functions such as wound healing, proteolytic activity, collagen degradation and cell growth, and the role of the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system has been studied in many disease states.
Ahmed Khudhur, Christopher Dowson, Susan M. Bissett, Rachel van de Merwe, John J. Taylor, Philip M. Preshaw, Katrin M. Jaedicke   +6 more
wiley   +1 more source

Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor

BMC Gastroenterology, 2006
Background The urokinase-type (uPA) and tissue-type (tPA) plasminogen activators regulate liver matrix remodelling through the conversion of plasminogen (Plg) to the active protease plasmin.
Bezerra Jorge A, Degen Jay L, Sabla Gregg E, Shanmukhappa Kumar   +3 more
doaj   +1 more source

Computational Graph Approach for Detection of Composite Human Activities [PDF]

arXiv, 2018
Existing work in human activity detection classifies physical activities using a single fixed-length subset of a sensor signal. However, temporally consecutive subsets of a sensor signal are not utilized. This is not optimal for classifying physical activities (composite activities) that are composed of a temporal series of simpler activities (atomic ...
arxiv  

Cultured bovine endothelial cells produce both urokinase and tissue-type plasminogen activators. [PDF]

, 1982
E G Levin, David J. Loskutoff
openalex   +1 more source

Expression of urokinase‐type plasminogen activator and plasminogen activator inhibitor in colon disease

Journal of Clinical Laboratory Analysis, 1995
AbstractSurveillance colonoscopy and biopsy are inaccurate methods of predicting the likelihood of ulcerative colitis patients to develop colon carcinoma. We examined uPA and PAI‐1 as potential markers for assessing these patients and those with familial polyposis who are at risk of developing colon cancer.
James L. Wittliff, Stephen D. Myers, Slobodan Miseljic, Susan Galandiuk   +3 more
openaire   +3 more sources