Results 31 to 40 of about 75,327 (314)

Separation and characterization of nonphosphorylated and serine-phosphorylated urokinase. Catalytic properties and sensitivity to plasminogen activator inhibitor type 1. [PDF]

, 1992
Urokinase synthesized by human A431 epidermoid carcinoma cells is phosphorylated on serine (Mastronicola, M. R., Stoppelli, M. P., Migliaccio, A., Auricchio, F., and Blasi, F. (1990) FEBS Lett. 266, 109-114).
D. De Cesare, Francesco Blasi, M P Stoppelli, M. L. Nolli, M. R. Mastronicola, Paola Franco, Pasquale Verde, Tze-Chei Wun   +7 more
core   +1 more source

Multiparity upregulates placental plasminogen and urokinase‐type plasminogen activator

American Journal of Reproductive Immunology, 2017
ProblemMultiparity increased the number of trophoblast cells in decidua of both low and high fetal loss mouse models. However, they differ in fetal survival rate and maternal thymocyte subpopulations, suggesting that trophoblast invasiveness is not equivalent.
María E. Cortina, Silvana Litwin, María R. Rial Hawila, Silvia Miranda   +3 more
openaire   +4 more sources

Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors

Scientific Reports, 2017
The urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored cell membrane receptor that focuses urokinase (uPA) proteolytic activity on the cell surface.
C. D. Mauro, A. Pesapane, L. Formisano, R. Rosa, V. D’Amato, P. Ciciola, A. Servetto, R. Marciano, Roberta C. Orsini, F. Monteleone, N. Zambrano, G. Fontanini, A. Servadio, G. Pignataro, L. Grumetto, A. Lavecchia, D. Bruzzese, A. Iaccarino, G. Troncone, B. M. Veneziani, N. Montuori, S. Placido, R. Bianco   +22 more
semanticscholar   +1 more source

Retinoic Acid Upregulates the Plasminogen Activator System in Human Epidermal Keratinocytes [PDF]

, 2001
The activation of the proteolytic plasminogen activator system is important for the re-epithelialization of skin wounds. Keratinocytes synthesize and secrete the urokinase-type plasminogen activator, which binds to its specific receptor on keratinocytes.
Braungart, Evelyn, Degitz, Klaus, Magdolen, Viktor   +2 more
core   +1 more source

Proenzyme to urokinase‐type plasminogen activator in the mouse in vivo [PDF]

FEBS Letters, 1985
We have investigated whether urokinase‐type plasminogen activator (u‐PA) is present in the mouse in vivo as the proenzyme or as the active enzyme. u‐PA in extracts of various murine tissues was of a one‐polypeptide chain form with an electrophoretic mobility indistinguishable from purified proenzyme (pro‐u‐PA), as demonstrated by SDS‐polyacrylamide gel
L.S. Nielsen, Peter A. Andreasen, V. Kielberg, J Grøndahl-Hansen, L. Skriver, Keld Danø   +5 more
openaire   +3 more sources

UVB Increases Urokinase-Type Plasminogen Activator Receptor (uPAR) Expression1 [PDF]

, 1999
Keratinocytes synthesize and secrete urokinase-type plasminogen activator, which binds to its specific receptor on keratinocytes. When bound to urokinase-type plasminogen activator receptor, urokinase-type plasminogen activator proteolytically converts ...
Braungart, Evelyn, Degitz, Klaus, Douwes, Kathrin, Lengyel, Ernst, Magdolen, Viktor, Marschall, Christoph, Nobutoh, Toshiko, Reuning, Ute, Simon, Aleksandra   +8 more
core   +1 more source

Urokinase-type Plasminogen Activator (uPA) Binding to the uPA Receptor (uPAR) Promotes Axonal Regeneration in the Central Nervous System*

Journal of Biological Chemistry, 2016
Axonal injury is a common cause of neurological dysfunction. Unfortunately, in contrast to axons from the peripheral nervous system, the limited capacity of regeneration of central nervous system (CNS) axons is a major obstacle for functional recovery in
Paola Merino, Ariel Diaz, V. Jeanneret, Fang Wu, E. Torre, Lihong Cheng, M. Yepes   +6 more
semanticscholar   +1 more source

Transcriptional regulation of the urokinase receptor (u-PAR) - A central molecule of invasion and metastasis [PDF]

, 2003
The phenomenon of tumor-associated proteolysis has been acknowledged as a decisive step in the progression of cancer. This short review focuses on the urokinase receptor (u-PAR), a central molecule involved in tumor-associated invasion and metastasis ...
Behrendt N., Bianchi E., Borglum A.D., Boyd D., Chapman H.A., Conese M., Cubellis M.V., Duffy M.J., Duffy M.J., Ellis V., Hollas W., Kariko K., Kook Y.H., Lakka S.S., Langer D.J., Leupold J.H., Lund L.R., Means A.L., Min H.Y., Mohanam S., Nekarda H., Pedersen H., Pyke C., Pyke C., Quattrone A., Resnati M., Roldan A., Schewe D., Shetty S., Soravia E., Suh T., Xue W.   +31 more
core   +1 more source

Nuclear translocation of urokinase-type plasminogen activator

Blood, 2008
AbstractUrokinase-type plasminogen activator (uPA) participates in diverse (patho)physiological processes through intracellular signaling events that affect cell adhesion, migration, and proliferation, although the mechanisms by which these occur are only partially understood. Here we report that upon cell binding and internalization, single-chain uPA (
Tatiana Lebedeva, Alice Kuo, Michael S. Marks, Abd Al-Roof Higazi, Abd Al-Roof Higazi, Yelena V. Parfyonova, Khalil Bdeir, Victoria Stepanova, Vsevolod A. Tkachuk, Sergei Tkachuk, Sergei Zaitsev, Inna Dumler, Douglas B. Cines, Serge Yarovoi   +13 more
openaire   +3 more sources

Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) in breast cancer - correlation with traditional prognostic factors

Radiology and Oncology, 2015
Background. Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) play a key role in tumour invasion and metastasis. High levels of both proteolytic enzymes are associated with poor prognosis in breast cancer patients ...
Lampelj Maja, Arko Darja, Cas-Sikosek Nina, Kavalar Rajko, Ravnik Maja, Jezersek-Novakovic Barbara, Dobnik Sarah, Dovnik Nina Fokter, Takac Iztok   +8 more
doaj   +1 more source