Results 31 to 40 of about 167,619 (306)

Multiparity upregulates placental plasminogen and urokinase‐type plasminogen activator

American Journal of Reproductive Immunology, 2017
ProblemMultiparity increased the number of trophoblast cells in decidua of both low and high fetal loss mouse models. However, they differ in fetal survival rate and maternal thymocyte subpopulations, suggesting that trophoblast invasiveness is not equivalent.
María E. Cortina, Silvana Litwin, María R. Rial Hawila, Silvia Miranda   +3 more
openaire   +4 more sources

Transcriptional regulation of the urokinase receptor (u-PAR) - A central molecule of invasion and metastasis [PDF]

, 2003
The phenomenon of tumor-associated proteolysis has been acknowledged as a decisive step in the progression of cancer. This short review focuses on the urokinase receptor (u-PAR), a central molecule involved in tumor-associated invasion and metastasis ...
Behrendt N., Bianchi E., Borglum A.D., Boyd D., Chapman H.A., Conese M., Cubellis M.V., Duffy M.J., Duffy M.J., Ellis V., Hollas W., Kariko K., Kook Y.H., Lakka S.S., Langer D.J., Leupold J.H., Lund L.R., Means A.L., Min H.Y., Mohanam S., Nekarda H., Pedersen H., Pyke C., Pyke C., Quattrone A., Resnati M., Roldan A., Schewe D., Shetty S., Soravia E., Suh T., Xue W.   +31 more
core   +1 more source

Nuclear translocation of urokinase-type plasminogen activator

Blood, 2008
AbstractUrokinase-type plasminogen activator (uPA) participates in diverse (patho)physiological processes through intracellular signaling events that affect cell adhesion, migration, and proliferation, although the mechanisms by which these occur are only partially understood. Here we report that upon cell binding and internalization, single-chain uPA (
Tatiana Lebedeva, Alice Kuo, Michael S. Marks, Abd Al-Roof Higazi, Abd Al-Roof Higazi, Yelena V. Parfyonova, Khalil Bdeir, Victoria Stepanova, Vsevolod A. Tkachuk, Sergei Tkachuk, Sergei Zaitsev, Inna Dumler, Douglas B. Cines, Serge Yarovoi   +13 more
openaire   +3 more sources

Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) in breast cancer - correlation with traditional prognostic factors

Radiology and Oncology, 2015
Background. Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) play a key role in tumour invasion and metastasis. High levels of both proteolytic enzymes are associated with poor prognosis in breast cancer patients ...
Lampelj Maja, Arko Darja, Cas-Sikosek Nina, Kavalar Rajko, Ravnik Maja, Jezersek-Novakovic Barbara, Dobnik Sarah, Dovnik Nina Fokter, Takac Iztok   +8 more
doaj   +1 more source

Plasminogen Mediates the Pathological Effects of Urokinase-Type Plasminogen Activator Overexpression [PDF]

The American Journal of Pathology, 2004
Increased expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) is associated with different pathological conditions. Both uPAR-mediated signaling and plasmin-catalyzed extracellular proteolysis may contribute to pathogenesis.
Bolon, Isabelle, Zhou, Hong-Ming, Charron, Yves, Wohlwend, Annelise Isabelle, Vassalli, Jean-Dominique   +4 more
openaire   +4 more sources

Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and α2-antiplasmin in human corneal perforation: a case report

BMC Ophthalmology, 2012
Background Corneal ulceration leading to perforation is associated with infectious and non-infectious destructive conditions in the cornea. The fibrinolytic (plasminogen/plasmin) system is considered to contribute to tissue remodeling in the wound ...
Sugioka Koji, Kodama Aya, Yoshida Koji, Okada Kiyotaka, Fukuda Masahiko, Shimomura Yoshikazu   +5 more
doaj   +1 more source

Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor

Communications Biology, 2021
Dowsett and colleagues used a genome-wide association approach to investigate the genetic influence on soluble urokinase-type plasminogen activator receptor presence in the plasma of humans.
Joseph Dowsett, Egil Ferkingstad, Line Jee Hartmann Rasmussen, Lise Wegner Thørner, Magnús K. Magnússon, Karen Sugden, Gudmar Thorleifsson, Mike Frigge, Kristoffer Sølvsten Burgdorf, Sisse Rye Ostrowski, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Thomas Folkmann Hansen, Karina Banasik, Søren Brunak, DBDS Genomic Consortium, Vinicius Tragante, Sigrun Helga Lund, Lilja Stefansdottir, Bjarni Gunnarson, Richie Poulton, Louise Arseneault, Avshalom Caspi, Terrie E. Moffitt, Daníel Gudbjartsson, Jesper Eugen-Olsen, Hreinn Stefánsson, Kári Stefánsson, Henrik Ullum   +29 more
doaj   +1 more source

Amiloride selectively inhibits the urokinase‐type plasminogen activator

FEBS Letters, 1987
The diuretic drug amiloride, an inhibitor of Na+ uptake, competitively inhibits the catalytic activity of the urokinase‐type plasminogen activator (u‐PA), with a K i of 7 × 10−6 M. Generation of plasmin, cleavage of peptide substrates, and interaction of u‐PA with a specific macromolecular proteinase inhibitor are all prevented in the presence of the ...
Vassalli, Jean-Dominique, Belin, Dominique   +1 more
openaire   +3 more sources

Dynamic Assembly of the Urokinase-type Plasminogen Activator Signaling Receptor Complex Determines the Mitogenic Activity of Urokinase-type Plasminogen Activator [PDF]

Journal of Biological Chemistry, 2005
The urokinase-type plasminogen activator (uPA) receptor (uPAR) functions in concert with co-receptors, including integrins, FPR-like receptor-1/lipoxin A4 receptor, and the epidermal growth factor receptor (EGFR), to initiate cell signaling. uPAR co-receptors may be dynamically organized into a multiprotein signaling receptor complex.
Corinne M. Silva, Steven L. Gonias, Tanay J. Amin, Minji Jo, Sarah J. Parsons, Nadzeya V. Marozkina, Keena S. Thomas   +6 more
openaire   +3 more sources

Early increases in plasminogen activator activity following partial hepatectomy in humans [PDF]

, 2004
Background Increases in urokinase-like plasminogen activator (uPA) activity are reported to be amongst the earliest events occurring in remnant liver following partial hepatectomy in rats, and have been proposed as a key component of the regenerative ...
Bird, N.C., Majeed, A.W., Mangnall, D., Smith, K.   +3 more
core   +2 more sources