Results 51 to 60 of about 75,327 (314)

Prognostic effects of SuPAR and Neopterin Levels on Patients with Lung Cancer

Pteridines, 2020
Background: Two unique biomarkers, soluble form of the urokinase-type plasminogen activator receptor (suPAR) and neopterin, play a crucial role in inflammatory processes.
Yalcin Selim, Demir Mehmet Emin, Ozturk Reyhan, Kılınç Aytün Şadan, Suer Hatice, Karahan Irfan   +5 more
doaj   +1 more source

UPAR Overexpression Could Be a Potential Favorable Prognostic Marker in Invasive Ductal Carcinoma of Breast

Acta Medica Iranica, 2022
Breast cancer is the most common malignant tumor in women. Some factors, including histological grade, vascular invasion, and metastasis, are known prognostic factors.
Ata Abbasi, Elnaz Mehdipour, Hengameh Mojdeganlou   +2 more
doaj   +1 more source

Immunohistochemical study of the plasminogen activator system in benign epithelial odontogenic lesions [PDF]

Brazilian Oral Research, 2022
: The aim of this study was to analyze and compare the immunohistochemical expression of plasminogen activator system (PAS) proteins (uPA, uPAR, and PAI-1) in ameloblastomas (AMBs), odontogenic keratocysts (OKCs), and dental follicles (DFs) representing ...
Carla Samily de Oliveira Costa, Rodrigo Porpino Mafra, Larissa Santos Amaral Rolim, Lélia Batista de Souza, Leão Pereira Pinto   +4 more
doaj   +1 more source

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]

, 2003
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R., Braungart, E., Degitz, K., Douwes, K., Flaig, M. J., Magdolen, V., Probst, C., Sander, C. A., Schuh, T., Wosikowski, K.   +9 more
core   +1 more source

Origin and diversification of the plasminogen activation system among chordates

BMC Evolutionary Biology, 2019
Background The plasminogen (PLG) activation system is composed by a series of serine proteases, inhibitors and several binding proteins, which together control the temporal and spatial generation of the active serine protease plasmin. As this proteolytic
Andrés Chana-Muñoz, Agnieszka Jendroszek, Malene Sønnichsen, Tobias Wang, Michael Ploug, Jan K. Jensen, Peter A. Andreasen, Christian Bendixen, Frank Panitz   +8 more
doaj   +1 more source

Expression pattern of the urokinase-plasminogen activator system in rat DS-sarcoma: Role of oxygenation status and tumour size [PDF]

The urokinase plasminogen activator system plays a central role in malignant tumour progression. Both tumour hypoxia and enhancement of urokinase plasminogen activator, urokinase plasminogen activator-receptor and plasminogen activator inhibitor type 1 ...
A Maity, AMB Stahl, CH Graham, CH Graham, CR Brudzinski, DK Kelleher, DSJ Brizel, EK Rofstad, GL Semenza, GU Dachs, H Chapman, HC Kwaan, I Sordat, JBD Vassalli, K Bajou, KL Sundfor, M Höckel, M Höckel, M Höckel, M Höckel, M Los, M Nordsmark, M Nordsmark, MS Yamamoto, O Thews, P Vaupel, P Vaupel, P Vaupel, P Workman, PA Andreasen, PA Andreasen, T Kietzmann, T Raff, U Reuning, Y Sugiura   +34 more
core   +2 more sources

Randomized adjuvant chemotherapy trial in high-risk, lymph node-negative breast cancer patients identified by urokinase-type plasminogen activator and plasminogen activator inhibitor type 1.

Journal of the National Cancer Institute, 2001
BACKGROUND Most patients with lymph node-negative breast cancer are cured by locoregional treatment; however, about 30% relapse. Because traditional histomorphologic and clinical factors fail to identify the high-risk patients who may benefit from ...
F. Jänicke, A. Prechtl, C. Thomssen, N. Harbeck, C. Meisner, M. Untch, C. Sweep, H. Selbmann, H. Graeff, M. Schmitt   +9 more
semanticscholar   +1 more source

A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease

Kidney International, 2014
It has been suggested that soluble urokinase receptor (suPAR) is a causative circulating factor for and a biomarker of focal and segmental glomerulosclerosis (FSGS).
Joann M. Spinale, L. Mariani, S. Kapoor, Jidong Zhang, R. Weyant, P. Song, Hetty N. Wong, J. Troost, C. Gadegbeku, D. Gipson, M. Kretzler, D. Nihalani, L. Holzman   +12 more
semanticscholar   +1 more source

Circulating Soluble Urokinase-Type Plasminogen Activator Receptor in Obstructive Sleep Apnoea

Medicina, 2020
Background and Objectives: Obstructive sleep apnoea (OSA) is associated with heightened systemic inflammation and a hypercoagulation state. Soluble urokinase-type plasminogen activator receptor (suPAR) plays a role in fibrinolysis and systemic ...
Renata Marietta Bocskei, Martina Meszaros, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Laszlo Kunos, Zsofia Lazar, Andras Bikov   +6 more
doaj   +1 more source

Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator.

Journal of Clinical Investigation, 1996
The primary hypothesis of this report is that the formation and subsequent removal of fibrin in specific tissues during pathologic processes reflects temporal changes in the local expression of key procoagulant and fibrinolytic genes.
Koji Yamamoto, D. Loskutoff
semanticscholar   +1 more source