Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]
, 2003 Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Brew K. +11 more
core +2 more sources
Review of Machine Learning Algorithms for Brain Stroke Diagnosis and Prognosis by EEG Analysis [PDF]
arXiv, 2020 Currently, strokes are the leading cause of adult disability in the United States. Traditional treatment and rehabilitation options such as physical therapy and tissue plasminogen activator are limited in their effectiveness and ability to restore mobility and function to the patient.
arxiv
The Roles of Fibrinolytic Factors in Bone Destruction Caused by Inflammation
CellsChronic inflammatory diseases, such as rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, Crohn’s disease, periodontitis, and carcinoma metastasis frequently result in bone destruction.
Yosuke Kanno
doaj +1 more source
Contemporary Perspectives on Chronic Renal Disorders
Chronic Diseases and Translational Medicine, EarlyView.ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok +5 more
wiley +1 more source
BSDGAN: Balancing Sensor Data Generative Adversarial Networks for Human Activity Recognition [PDF]
arXiv, 2022 The development of IoT technology enables a variety of sensors can be integrated into mobile devices. Human Activity Recognition (HAR) based on sensor data has become an active research topic in the field of machine learning and ubiquitous computing. However, due to the inconsistent frequency of human activities, the amount of data for each activity in
arxiv
Urokinase-Type Plasminogen Activator Receptor: A Beacon of Malignancy? [PDF]
Clinical Cancer Research, 2008 Abstract Discriminating between benign and malignant disease is a pivotal diagnostic issue in the care of women with pelvic masses. Identification of serum biomakers that can rellably make the distinction would aid in the proper referral for patient care and may provide leads in the development of early detection strategies.
Steven J. Skates +2 more
openaire +3 more sources
Current and novel biomarkers in cardiogenic shock
European Journal of Heart Failure, EarlyView.A summary of current and novel biomarkers and their potential stages of release in cardiogenic shock. The diagram illustrates the proposed release of the biomarkers during the different stages of cardiogenic shock: progression from cardiac dysfunction/stress, through to inflammation and end‐organ dysfunction.
Victor Galusko +5 more
wiley +1 more source
PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology [PDF]
, 2018 The fibrinolysis proteinase tissue-type plasminogen activator (tPA, also known as PLAT) triggers cell signaling and regulates cell physiology. In PC12 cells, Schwann cells and macrophages, the N-methyl-D-aspartate receptor (NMDA-R) mediates tPA signaling.
Azmoon, Pardis +5 more
core +2 more sources
Urokinase-type plasminogen activator receptor in IgA nephropathy
The Korean Journal of Internal Medicine, 2014 See Article on Page 176-182 IgA nephropathy (IgAN) is the most common pathologic form of primary glomerulonephritis and accounts for up to 50% of cases of this condition diagnosed using renal biopsy in Korea [1]. The most common pathologic findings related to the development of end-stage renal disease were global sclerosis, segmental sclerosis ...
Shin Young Ahn, Ho Jun Chin
openaire +3 more sources
Antithrombotic therapy and expression of plasminogen activator genes in ischemic brain 1) Comparison of the antithrombotic effects and bleeding risk of fractionated aurin tricarboxylic acid and the GPIIb/IIIa antagonist GR144053 in a hamster model of stenosis 2) Elevation of mRNA levels of tissue-type plasminogen activator and urokinase-type plasminogen activator in hippocampus and cerebral cortex following middle cerebral artery occlusion in rats [PDF]
, 2001 博士論文 (Doctoral dissertation)1) Comparison of the antithrombotic effects and bleeding risk of fractionated aurin tricarboxylic acid and the GPIIb/IIIa antagonist GR144053 in a hamster model of stenosis2) Elevation of mRNA levels of tissue-type plasminogen
397383, 伊藤, 毅
core