Results 81 to 90 of about 48,370 (295)

Microenvironment‐Guided Evolution of ssDNA‐SWCNT Probes for Selective Recognition of Aggressive Prostate Cancer Phenotypes

Advanced Science, EarlyView.
Random ssDNA–SWCNT(single strand DNA‐single walled carbon nanotube) library is functionally screened and evolved using high‐throughput 3D prostate tumor spheroids via iterative positive and negative selection, enabling the identification of NIR‐II fluorescent ssDNA‐SWCNT nanoprobe specific for prostate cancer.
Dakyeon Lee, Seok‐Hyeon Lee, Yunseo Jung, Jeongho Lee, Min‐Seo Choi, SaeOck Oh, Sungjee Kim, Byoung Soo Kim, Sanghwa Jeong   +8 more
wiley   +1 more source

Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling. [PDF]

, 2015
In glioblastoma (GBM), the EGF receptor (EGFR) and Src family kinases (SFKs) contribute to an aggressive phenotype. EGFR may be targeted therapeutically; however, resistance to EGFR-targeting drugs such as Erlotinib and Gefitinib develops quickly.
Cavenee, WK, Furnari, FB, Gonias, SL, Hu, J, Muller, KA, VandenBerg, SR   +5 more
core  

MO266: Deficiency of Urokinase-Type Plasminogen Activator Exacerbates CBSA-Induced Membranous Nephropathy in Mice [PDF]

, 2022
Tzu‐Ming Jao, Chian-Huei Guo, Chia-Yu Bai, Jin‐Shuen Chen   +3 more
openalex   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients [PDF]

, 2002
BACKGROUND: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are associated with poor prognosis in breast cancer patients ...
Beex, L.V. (Louk), Bendahl, P.O., Blankenstein, M.A. (Marinus), Borstnar, S., Broet, P., Brunner, N., Christensen, I.J., Cufer, T., Daver, A., Daxenbichler, G., Duffy, M.J. (Michael), Duggan, C., Eppenberger, U., Eppenberger-Castori, S. (Serenella), Ferno, M., Fiets, W.E., Foekens, J.A. (John), Harbeck, N. (Nadia), Janicke, F., Kates, R. (Ronald), Klijn, J.G.M. (Jan), Kueng, W., Lisboa, B.W., Look, M.P. (Maxime), Magdelenat, H., Manders, P. (Peggy), Martin, P.M., Meijer van Gelder, M.E. (Marion), O'Higgins, N., Peyrat , J.P., Putten, W.L.J. (Wim) van, Quillien, V., Ricolleau, G., Romain, S., Schmitt, M. (Manfred), Spyratos, F., Sweep, C.G., Thomssen, C. (Christoph), Ulm, K., Windbichler, G.   +39 more
core   +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source

Clinical Evidence for Correlation of Insufficient Tissue Oxygen Supply (Hypoxia) and Tumor-Associated Proteolysis in Squamous Cell Carcinoma of the Head and Neck

The International Journal of Biological Markers, 2000
Hypoxic tumors of patients with squamous cell carcinoma of the head and neck show a consistent trend towards poor treatment outcome. We now report that tumor hypoxia in these patients is correlated with elevated antigen content of the tumor-associated ...
P. Stadler, H.J. Feldmann, C. Creighton, H.-F. Zeilhoffer, V. Zimmermann, M. Schmitt, M. Molls   +6 more
doaj   +1 more source

Expression pattern of the urokinase-plasminogen activator system in rat DS-sarcoma: Role of oxygenation status and tumour size [PDF]

The urokinase plasminogen activator system plays a central role in malignant tumour progression. Both tumour hypoxia and enhancement of urokinase plasminogen activator, urokinase plasminogen activator-receptor and plasminogen activator inhibitor type 1 ...
A Maity, AMB Stahl, CH Graham, CH Graham, CR Brudzinski, DK Kelleher, DSJ Brizel, EK Rofstad, GL Semenza, GU Dachs, H Chapman, HC Kwaan, I Sordat, JBD Vassalli, K Bajou, KL Sundfor, M Höckel, M Höckel, M Höckel, M Höckel, M Los, M Nordsmark, M Nordsmark, MS Yamamoto, O Thews, P Vaupel, P Vaupel, P Vaupel, P Workman, PA Andreasen, PA Andreasen, T Kietzmann, T Raff, U Reuning, Y Sugiura   +34 more
core   +2 more sources

Biophysical Mechanisms Mediating Fibrin Fiber Lysis [PDF]

, 2017
The formation and dissolution of blood clots is both a biochemical and a biomechanical process. While much of the chemistry has been worked out for both processes, the influence of biophysical properties is less well understood. This review considers the
Hudson, Nathan E.
core   +2 more sources