Results 131 to 140 of about 8,317,164 (175)

Hyperglycemia is associated with lower levels of urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor in wound fluid

Journal of Diabetes and its Complications, 2014
Wounds in patients with hyperglycemia show impaired healing. Plasminogen activation is crucial in several overlapping phases of wound healing process. In this study, we aimed i) to compare acute wound fluid in patients with hyperglycemia and normoglycemia, ii) to focus on the elements of plasminogen activation in the wound fluid, and iii) to determine ...
Terzi, Cem, AKINCI, BARIŞ, Yesil, Sena, Tunali, Sunay, Tunc, Ulku Aybuke, Yuksel, Faize, Sevindik, Gokmen   +6 more
openaire   +3 more sources

Expression of urokinase-type plasminogen activator receptor in hepatocellular carcinoma

Hepatology, 1997
It is well known that a urokinase-type plasminogen activator receptor (uPAR) is a key protein in the plasminogen activation system, which plays a proteolytically important role in the invasion and metastasis of various cancer cells.
Y, Morita, Y, Hayashi, Y, Wang, T, Kanamaru, S, Suzuki, K, Kawasaki, K, Ohta, M, Yamamoto, Y, Saitoh, H, Itoh, W F, Doe   +10 more
openaire   +2 more sources

Characterization of the Binding of Urokinase-Type Plasminogen Activator to the Asialoglycoprotein Receptor

Thrombosis and Haemostasis, 2002
SummaryIn order to study the role of the asialoglycoprotein receptor (ASGPr) in the rapid plasma clearance of urokinase-type plasminogen activator (u-PA), a microtiter plate binding assay was developed using ASGPr purified from rat liver extracts. Urinary two-chain u-PA bound to immobilized ASGPr in a saturable manner with an EC50 of 0.2 µM.
D C, Rijken, M E, van der Kaaden, E, Groeneveld, M M, Barrett-Bergshoeff, Th J C, van Berkel, J, Kuiper   +5 more
openaire   +2 more sources

Novel protein interactors of urokinase-type plasminogen activator receptor

Biochemical and Biophysical Research Communications, 2010
The urokinase-type plasminogen activator receptor (uPAR) has been implicated in tumor growth and metastasis. The crystal structure of uPAR revealed that the external surface is largely free to interact with a number of proteins. Additionally, due to absence of an intracellular cytoplasmic protein domain, many of the biological functions of uPAR ...
Mekkawy, Ahmed H., De Bock, Charles E., Lin, Zhen, Morris, David L., Wang, Yao, Pourgholami, Mohammad H.   +5 more
openaire   +2 more sources

Evaluation of plasma urokinase-type plasminogen activator and urokinase-type plasminogen-activator receptor in patients with acute and chronic hepatitis B

Thrombosis Research, 2009
Urokinase-type plasminogen activator (uPA) and urokinase-type plasminogen activator receptor (uPAR) are known to be important factors in the pathogenesis of tumors and certain non-viral inflammatory diseases. However, their role in infectious virus diseases such as hepatitis B has been less well studied. This study aimed to test the hypothesis that the
Huanqin, Zhou, Xianguo, Wu, Xingguo, Lu, Gang, Chen, Xiongwei, Ye, Jian, Huang   +5 more
openaire   +2 more sources

Expression of urokinase‐type plasminogen activator receptor and plasminogen activator inhibitor‐1 in gastric cancer

Journal of Gastroenterology and Hepatology, 1998
ABSTRACTIn gastric cancer, the urokinase‐type plasminogen activator (uPA) system plays important roles in invasion and metastasis, processes which entail proteolysis and adhesion. Both the urokinasetype plasminogen activator receptor (uPAR) and the plasminogen activator inhibitor‐1 (PAI‐1) are thought to be important factors in this system.
K, Kawasaki, Y, Hayashi, Y, Wang, S, Suzuki, Y, Morita, T, Nakamura, K, Narita, W, Doe, H, Itoh, Y, Kuroda   +9 more
openaire   +2 more sources

Induction of Urokinase-Type Plasminogen Activator Receptor by IL-1 β

American Journal of Respiratory Cell and Molecular Biology, 1997
Abstract Extensive tissue remodeling occurs in survivors of acute lung injury, leading to nearly normal histology and physiology in the majority of individuals, whereas others suffer significant impairment due to the development of pulmonary fibrosis. Alveolar epithelial cells play a central role in the repair process.
T, Hasegawa, L, Sorensen, M, Dohi, N V, Rao, J R, Hoidal, B C, Marshall   +5 more
openaire   +2 more sources

Functional involvement of urokinase‐type plasminogen activator receptor in pemphigus acantholysis

Journal of Cutaneous Pathology, 1998
Urokinase‐type plasminogen activator (uPA) has been well documented in the development of pemphigus acantholysis. The function of its receptor (uPA‐R) in pemphigus acantholysis has only recently attracted attention. Increased expression of uPA‐R has been demonstrated in pemphigus vulgaris.
W, Xue, K, Hashimoto, Y, Toi
openaire   +2 more sources

Modulation of the urokinase-type plasminogen activator receptor by the β6 integrin subunit

Biochemical and Biophysical Research Communications, 2004
Over-expression of components of the urokinase system is well documented in cancer and is thought to enable tumour cells to migrate and invade. Changes in integrin expression are also a common feature of tumours and have been linked to changes in protease activity.
Dalvi, Nafisa, Thomas, Gareth J., Marshall, John F., Morgan, Mark, Bass, Rosemary, Ellis, Vincent, Speight, Paul M., Whawell, Simon A.   +7 more
openaire   +4 more sources

Structure and Inhibition of the Urokinase-Type Plasminogen Activator Receptor

2008
The urokinase-type plasminogen activator receptor (uPAR/CD87) is a glycolipid-anchored receptor that is involved in focalizing plasminogen activation to the cell surface due to its high-affinity binding to the urokinase-type plasminogen activator (uPA).
Benedikte Jacobsen, Magnus Kjaergaard, Henrik Gårdsvoll, Michael Ploug   +3 more
openaire   +1 more source