Results 71 to 80 of about 8,317,164 (175)

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source

Pathogenic and Regulatory Roles of Fibrinolytic Factors in Autoimmune Diseases

Current Issues in Molecular Biology
Autoimmune diseases arise from complex interactions of genetic, environmental, and hormonal factors, yet their precise causes remain elusive. Beyond its canonical role in fibrin degradation, the fibrinolytic system is increasingly recognized as both a ...
Yosuke Kanno
doaj   +1 more source

Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Periodontitis: A Case–Control Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Introduction The plasminogen activating (PA) system has a multitude of functions such as wound healing, proteolytic activity, collagen degradation and cell growth, and the role of the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system has been studied in many disease states.
Ahmed Khudhur, Christopher Dowson, Susan M. Bissett, Rachel van de Merwe, John J. Taylor, Philip M. Preshaw, Katrin M. Jaedicke   +6 more
wiley   +1 more source

Rhenium‐Based β‐Galactosidase Probe Allows Senescence Profiling by Mass Cytometry

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Senescence‐associated β‐galactosidase (SA‐β‐Gal) activity is a widely accepted biomarker of cellular senescence, yet its integration with other senescence markers has been limited by available detection methods. Here, we introduce ReGal, a mass cytometry‐compatible SA‐β‐Gal activity probe that can be multiplexed with established markers of senescence ...
Adam Tam, Kris Elbein, Aleida G. Gonzalez, Edgar A. Arriaga, Mark Nitz   +4 more
wiley   +2 more sources

Akhirin Preserves Hemostatic Wound Repair Through Non-Hematopoietic Regulation of the Vascular Injury Microenvironment

Journal of Developmental Biology
Hemostasis and wound healing are highly coordinated processes that involve rapid clot formation followed by controlled remodeling of the injured tissue microenvironment.
Mohammad Badrul Anam, Mikiko Kudo, Terumasa Umemoto, Keisuke Yamashita, Rie Kawano, Kunimasa Ohta   +5 more
doaj   +1 more source

uPA‐PAI‐1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils

EMBO Molecular Medicine, 2021
High intratumoral levels of urokinase‐type plasminogen activator (uPA)‐plasminogen activator inhibitor‐1 (PAI‐1) heteromers predict impaired survival and treatment response in early breast cancer.
Bernd Uhl, Laura A Mittmann, Julian Dominik, Roman Hennel, Bojan Smiljanov, Florian Haring, Johanna B Schaubächer, Constanze Braun, Lena Padovan, Robert Pick, Martin Canis, Christian Schulz, Matthias Mack, Ewgenija Gutjahr, Peter Sinn, Jörg Heil, Katja Steiger, Sandip M Kanse, Wilko Weichert, Markus Sperandio, Kirsten Lauber, Fritz Krombach, Christoph A Reichel   +22 more
doaj   +1 more source

Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source

Video from Structure-based design of an urokinase-type plasminogen activator receptor–derived peptide inhibiting cell migration and lung metastasis

, 2009
Video from Structure-based design of an urokinase-type plasminogen activator receptor–derived peptide inhibiting cell migration and lung ...
Mario De Rosa (15040481), Liliana Lista (2709868), Giuseppina Votta (2141533), Maria Vincenza Carriero (8713431), Renato Franco (184143), Maria Teresa Masucci (15040478), Maria Patrizia Stoppelli (133653), Katia Bifulco (133627), Vincenzo Pavone (133641), Claudio Arra (133331), Antonio Barbieri (458558), Immacolata Longanesi-Cattani (133632), Ornella Maglio (4379920)   +12 more
core   +1 more source

Tumor markers in breast cancer - European Group on Tumor Markers recommendations [PDF]

, 2005
Recommendations are presented for the routine clinical use of serum and tissue-based markers in the diagnosis and management of patients with breast cancer.
Einarsson, Roland, Barak, Vivian, Dalen, Arie van, Duffy, Michael J., Nap, Marius, Gion, Massimo, Molina, Rafael, Lamerz, Rolf, Sölétormos, György, Goike, Helena, Stieber, Petra   +10 more
core   +1 more source

Effect of Plasma Soluble Urokinase-Type Plasminogen Activator Receptor and Plasminogen Activator Inhibitor-1 Levels in the Plasma of Babylon Women with Breast Cancer

Medical Journal of Babylon
Background: Worldwide, the occurrence of breast cancer is elevated as well as the number of mortality in women cancers. The movement of cancer cells from the first stage and invasion of the surrounding tissue are called cancer metastasis.
Sheerin H. Abbas, Zinah Abbass Ali, Alaa Sadiq Alaawad   +2 more
doaj   +1 more source