Contemporary Perspectives on Chronic Renal Disorders
ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok+5 more
wiley +1 more source
Molecular-specific urokinase antibodies [PDF]
Antibodies have been developed against the different molecular forms of urokinase using synthetic peptides as immunogens. The peptides were synthesized specifically to represent those regions of the urokinase molecules which are exposed in the three ...
Atassi, M. Zouhair, Morrison, Dennis R.
core +1 more source
Studies on Plasminogen Activators. II. A Method for the Separation of Purified Urokinase from Small Samples of Urine. [PDF]
Ulla Hamberg+7 more
openalex +1 more source
Neutrophil extracellular traps in cancer: From mechanisms to treatments
Neutrophil extracellular traps are intricately linked to the tumor microenvironment and play a crucial role in tumorigenesis, metastasis, and related complications. Consequently, NETs‐based tumor biomarkers and therapeutic strategies warrant significant attention.
Yifan Wang+5 more
wiley +1 more source
New horizons in the pharmacological management of venous thromboembolism
Abstract Many patients suffer from venous thromboembolism (VTE) and its consequences. Despite substantial advancements with the introduction of direct oral anticoagulants (DOACs), patients and clinicians still encounter challenges in the acute and long‐term management of VTE, such as recurrent events, anticoagulant‐related bleeding complications, and ...
Andreas Verstraete+3 more
wiley +1 more source
Acute modified Blalock-Taussing shunt obstruction successfully treated with urokinase and heparin [PDF]
Acute modified Blalock-Tuassig shunt obstruction due to thrombosis may be lifethreatening. We report non-invasive relief of shunt obstruction with thrombolysis and heparinisation, a potentially life-saving intervention that is applicable in all ...
Grech, Victor E., Mizzi, Joseph
core +1 more source
Analysis of Differentially Expressed Proteins Involved in Shrimp and Crab Allergies
Using proteomics techniques, we identified 90 differentially expressed proteins in children with shrimp and crab allergies compared to normal controls, with 82 upregulated and 8 downregulated proteins. Validation of MRC2 upregulation by ELISA in allergic patients highlights the potential role of this protein in the allergic response.
Ruhong Tan+4 more
wiley +1 more source
Numerical study of cancer cell invasion dynamics using adaptive mesh refinement: the urokinase model
In the present work we investigate the chemotactically and proteolytically driven tissue invasion by cancer cells. The model employed is a system of advection-reaction-diffusion equations that features the role of the serine protease urokinase-type ...
Hellmann, Nadja+4 more
core
Primary Structure of Peptides Released during Activation of Human Plasminogen by Urokinase [PDF]
Björn Wiman
openalex +1 more source
ABSTRACT Septic shock is characterised by abnormal coagulation activation with defective fibrinolysis, leading to a high mortality rate. Cellular activation triggers the release of extracellular vesicles (EVs) conveying both procoagulant and fibrinolytic activities.
Romaric Lacroix+20 more
wiley +1 more source