Results 31 to 40 of about 43,123 (212)

Urokinase vs Tissue-Type Plasminogen Activator for Thrombolytic Evacuation of Spontaneous Intracerebral Hemorrhage in Basal Ganglia

Frontiers in Neurology, 2017
Spontaneous intracerebral hemorrhage (ICH) is a devastating form of stroke, which leads to a high rate of mortality and poor neurological outcomes worldwide.
Yuqian Li, Ruixin Yang, Zhihong Li, Bo Tian, Xingye Zhang, Jiancai Wang, Longlong Zheng, Boliang Wang, Lihong Li   +8 more
doaj   +1 more source

Hippocampal Viral-Mediated Urokinase Plasminogen Activator (uPA) Overexpression Mitigates Stress-Induced Anxiety and Depression in Rats by Increasing Brain-Derived Neurotrophic Factor (BDNF) Levels

Biomolecules
Emerging evidence suggests the serine protease, urokinase plasminogen activator (uPA), may play an important role in the modulation of mood and cognitive functions. Also, preliminary evidence indicates that uPA modulates BDNF activity that is known to be
Amine Bahi, Jean-Luc Dreyer
doaj   +1 more source

Thrombectomy combined with indwelling-catheter thrombolysis is more effective than pure thrombectomy for the treatment of lower extremity deep venous thrombosis

Open Medicine, 2017
This study was a retrospective analysis of the efficacy of thrombectomy plus local catheter-directed thrombolysis (CDT) for the treatment of lower extremity deep venous thrombosis (LDVT).
Wang Wenli, Wu Yanfang, Fang Tao, Xu Dunyuan   +3 more
doaj   +1 more source

Urokinase-based lock solutions for catheter salvage: A case of an upcoming kidney transplant recipient

Open Medicine, 2023
Catheter-related bloodstream infection (CRBSI) is a significant complication among patients on haemodialysis (HD) who are dependent on a central venous catheter (CVC) for an extended period. Catheter removal as first-line treatment can induce accelerated
Xia Cong, Fan Junfen, Xu Chao, Hu Shouci, Ma Hongzhen, He Lingzhi, Ye Liqing   +6 more
doaj   +1 more source

Construction of ultrasound-responsive urokinase precise controlled-release nanoliposome applied for thrombolysis

Frontiers in Bioengineering and Biotechnology, 2022
Urokinase is widely used in the dissolution of an acute pulmonary embolism due to its high biocatalytic effect. However, how to precisely regulate its dose, avoid the side effects of hemolysis or ineffective thrombolysis caused by too high or too low a ...
Yongliang Fan, Yongliang Fan, Li Liu, Fang Li, Hang Zhou, Yizhou Ye, Chunping Yuan, Hongli Shan, Wangfu Zang, Yu Luo, Sijing Yan   +10 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Ultrasound-Guided Urokinase in the Remedy of Spontaneous Vaginal Hematoma After Vaginal Delivery: A Case Report

International Journal of Women's Health, 2023
Jin Shang,1 Juan Li,2 Qing Bai,2 Yongmei Wang,2 Hongjian Chen,1 Shunxu Li2 1Department of Ultrasound, The Third People’s Hospital of Yunnan, Kunming, People’s Republic of China; 2Department of Obstetrics, The Third People’s Hospital of Yunnan, Kunming ...
Shang J, Li J, Bai Q, Wang Y, Chen H, Li S   +5 more
doaj  

Intrapleural urokinase directly under medical thoracoscopy for the diagnosis of tuberculous pleurisy

Respirology Case Reports, 2020
Medical thoracoscopy, also called “local anesthetic thoracoscopy” and “pleuroscopy,” is a minimally invasive single‐port endoscopic technique that provides direct visualization of the pleural surfaces and channels to conduct diagnostic and therapeutic ...
Satoshi Terashita, Hiroaki Kawachi, Tomoko Tajiri, Susumu Noguchi, Tatsuyoshi Ikeue, Takakazu Sugita   +5 more
doaj   +1 more source

Dissolution Effect of Alteplase on Arterial Blood Clot Model of Hypertensive Intracerebral Hemorrhage Patients in vitro

Frontiers in Neurology, 2022
ObjectiveTo explore the dissolution effect of alteplase (rt-PA) on arterial blood clots of patients with hypertensive cerebral hemorrhage in vitro and analyze the optimal concentration and action time of rt-PA for intracranial hematomas.MethodsThe ...
Xiaoming Jiang, Yongyu Lu, Xiaogang Hu, Xiaochun She   +3 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source