Results 31 to 40 of about 99,653 (320)

Bridging a Century-Old Problem: The Pathophysiology and Molecular Mechanisms of HA Filler-Induced Vascular Occlusion (FIVO)—Implications for Therapeutic Interventions

Molecules, 2022
Biocompatible hyaluronic acid (HA, hyaluronan) gel implants have altered the therapeutic landscape of surgery and medicine, fostering an array of innovative products that include viscosurgical aids, synovial supplements, and drug-eluting nanomaterials ...
Danny J. Soares
doaj   +1 more source

Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells. [PDF]

, 2017
The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion.
De Lorenzi, Valentina, Jalink, Kees, Kedziora, Katarzyna M., Leyton-Puig, Daniela, Matas-Rico, Elisa, Moolenaar, Wouter H., Perrakis, Anastassis, Sidenius, Nicolai, Stijf-Bultsma, Yvette, van de Wetering, Koen, van den Broek, Bram, van Veen, Michiel   +11 more
core   +3 more sources

Safety and Efficacy of Intra-arterial Urokinase After Failed, Unsuccessful, or Incomplete Mechanical Thrombectomy in Anterior Circulation Large-Vessel Occlusion Stroke.

JAMA Neurology, 2019
Importance Achieving complete reperfusion is a key determinant of good outcome in patients treated with mechanical thrombectomy (MT). However, data on treatments geared toward improving reperfusion after incomplete MT are sparse. Objective To determine
J. Kaesmacher, Sebastian Bellwald, T. Dobrocky, T. Meinel, E. Piechowiak, M. Goeldlin, C. Kurmann, M. Heldner, Simon Jung, P. Mordasini, M. Arnold, P. Mosimann, G. Schroth, H. Mattle, J. Gralla, U. Fischer   +15 more
semanticscholar   +1 more source

Urokinase Regulates Vitronectin Binding by Controlling Urokinase Receptor Oligomerization [PDF]

Journal of Biological Chemistry, 2002
Adhesion of monocytes to the extracellular matrix is mediated by a direct high affinity interaction between cell-surface urokinase-type plasminogen activator (uPA) receptor (uPAR) and the extracellular matrix protein vitronectin. We demonstrate a tight connection between uPA-regulated uPAR oligomerization and high affinity binding to immobilized ...
N. SIDENIUS, A. ANDOLFO, FESCE, RICCARDO GIUSEPPE, F. BLASI   +3 more
openaire   +5 more sources

Soluble Urokinase Receptor and Chronic Kidney Disease.

New England Journal of Medicine, 2015
BACKGROUND Relatively high plasma levels of soluble urokinase-type plasminogen activator receptor (suPAR) have been associated with focal segmental glomerulosclerosis and poor clinical outcomes in patients with various conditions.
S. Hayek, Sanja Sever, Y. Ko, H. Trachtman, Mosaab Awad, S. Wadhwani, M. Altintas, Changli Wei, A. Hotton, A. French, L. Sperling, S. Lerakis, A. Quyyumi, J. Reiser   +13 more
semanticscholar   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Brew K., Kitts P.A., Kos J., Kotzsch M., Lah T.T., Magdolen U., Possee R.D., Rabbani S.A., Reuning U., Stetler-Stevenson W.G., Szpaderska A.M., Thomas C.J.   +11 more
core   +2 more sources

Combining National Early Warning Score With Soluble Urokinase Plasminogen Activator Receptor (suPAR) Improves Risk Prediction in Acute Medical Patients: A Registry-Based Cohort Study*

Critical Care Medicine, 2018
Objectives: Soluble urokinase plasminogen activator receptor is a prognostic biomarker associated with critical illness, disease progression, and risk of mortality.
L. Rasmussen, S. Ladelund, T. Haupt, G. Ellekilde, J. Eugen-Olsen, O. Andersen   +5 more
semanticscholar   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Early increases in plasminogen activator activity following partial hepatectomy in humans [PDF]

, 2004
Background Increases in urokinase-like plasminogen activator (uPA) activity are reported to be amongst the earliest events occurring in remnant liver following partial hepatectomy in rats, and have been proposed as a key component of the regenerative ...
Bird, N.C., Majeed, A.W., Mangnall, D., Smith, K.   +3 more
core   +2 more sources

Role of multidomain structure of urokinase in regulation of growth and remodeling of vessels [PDF]

The Ukrainian Biochemical Journal, 2013
Urokinase type plasminogen activator, or urokinase (uPA), is a multifunctional protein which plays special regulatory role in the vascular wall and can actuate the proteolytic and signal cascades.
V. A. Tkachuk, O. S. Plekhanova, I. B. Beloglazova, E. V. Parfenova   +3 more
doaj   +1 more source