Results 51 to 60 of about 99,653 (320)

Intrapleural urokinase directly under medical thoracoscopy for the diagnosis of tuberculous pleurisy

Respirology Case Reports, 2020
Medical thoracoscopy, also called “local anesthetic thoracoscopy” and “pleuroscopy,” is a minimally invasive single‐port endoscopic technique that provides direct visualization of the pleural surfaces and channels to conduct diagnostic and therapeutic ...
Satoshi Terashita, Hiroaki Kawachi, Tomoko Tajiri, Susumu Noguchi, Tatsuyoshi Ikeue, Takakazu Sugita   +5 more
doaj   +1 more source

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA [PDF]

, 2009
HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity.
Andrew M. Schumacher, Birchmeier, Bugge, Chirgadze, Collen, Deyi Qiu, Ellis, Ellis, Gherardi, Harris, Herter, Høyer-Hansen, Itoh, Jennifer L. Harris, Juliano Alves, Jun Li, Kate A. Owen, Ke, Kemp, Kilpatrick, Kirchhofer, Kirchhofer, Lamszus, Lee, Lynette M. Kilpatrick, Mangel, Marcotte, Mars, Mars, Matsuoka, Miyazawa, Mizuno, Mohammed, Naldini, Naldini, Qiu, Rahman, Riddick, Schmidt, Shanmukhappa, Shimizu, Shimomura, Steinmetzer, Stephens, Takeuchi, Uehara, Vincent Ellis, You   +47 more
core   +3 more sources

PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism.

Stroke, 1998
BACKGROUND AND PURPOSE To test the safety and recanalization efficacy of intra-arterial local delivery of plasminogen activators in acute ischemic stroke, a randomized trial of recombinant pro-urokinase (rpro-UK) versus placebo was undertaken in patients
G. Zoppo, R. Higashida, A. Furlan, M. Pessin, H. Rowley, M. Gent   +5 more
semanticscholar   +1 more source

Diabetes decreases patency of tunneled catheters in hemodialysis patients after first effective thrombolysis with urokinase

Renal Failure, 2018
Introduction: Fibrinolysis is one of the methods extending the use of vascular access in patients with tunneled venous catheters thrombosis. The aim of this study was to assess one-year maintenance of tunneled catheters patency after first effective ...
Dominika Wójtowicz, Dominika Cholewa, Anna M. Faba, Beata Domańska, Joanna Kokoszka, Konrad Kopacz, Rafał Ficek, Tomasz Irzyniec, Sylwia E. Rotkegel, Jerzy Chudek   +9 more
doaj   +1 more source

Minimally-invasive bedside catheter haematoma aspiration followed by local thrombolysis in spontaneous supratentorial intracerebral haemorrhage: a retrospective single-center study

Frontiers in Neurology, 2023
Background and purposeThe role of surgery in the treatment of intracerebral haemorrhage (ICH) remains controversial. Whereas open surgery has failed to show any clinical benefit, recent studies have suggested that minimal invasive procedures can indeed ...
Maren Hieber, Johann Lambeck, Amjad Halaby, Roland Roelz, Theo Demerath, Wolf-Dirk Niesen, Jürgen Bardutzky   +6 more
doaj   +1 more source

HGF modulates actin cytoskeleton remodeling and contraction in testicular myoid cells [PDF]

, 2015
The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in
Angela, Catizone, Caruso, Maria, Galdieri, Michela, Ricci, Giulia, Rita, Canipari, Scheri, Katia Corano, Virginia, Di Paolo   +6 more
core   +1 more source

Viral load at hospitalization is an independent predictor of severe COVID‐19

, 2023
European Journal of Clinical Investigation, Volume 53, Issue 1, January 2023.
Hjalmar Waller, Noelia Carmona‐Vicente, Axel James, Melissa Govender, Francis R. Hopkins, Marie Larsson, Marie Hagbom, Lennart Svensson, Helena Enocsson, Annette Gustafsson, Åsa Nilsdotter‐Augustinsson, Johanna Sjöwall, Johan Nordgren   +12 more
wiley   +1 more source

Construction of ultrasound-responsive urokinase precise controlled-release nanoliposome applied for thrombolysis

Frontiers in Bioengineering and Biotechnology, 2022
Urokinase is widely used in the dissolution of an acute pulmonary embolism due to its high biocatalytic effect. However, how to precisely regulate its dose, avoid the side effects of hemolysis or ineffective thrombolysis caused by too high or too low a ...
Yongliang Fan, Yongliang Fan, Li Liu, Fang Li, Hang Zhou, Yizhou Ye, Chunping Yuan, Hongli Shan, Wangfu Zang, Yu Luo, Sijing Yan   +10 more
doaj   +1 more source

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]

, 2003
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R., Braungart, E., Degitz, K., Douwes, K., Flaig, M. J., Magdolen, V., Probst, C., Sander, C. A., Schuh, T., Wosikowski, K.   +9 more
core   +1 more source

Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells.

Nephrology, Dialysis and Transplantation, 2015
BACKGROUND Diabetic nephropathy (DN) is associated with hypertension, expanded extracellular volume and impaired renal Na(+) excretion. It was hypothesized that aberrant glomerular filtration of serine proteases in DN causes proteolytic activation of the
H. Andersen, U. Friis, P. Hansen, P. Svenningsen, J. Henriksen, B. Jensen   +5 more
semanticscholar   +1 more source