Results 181 to 190 of about 1,484,561 (230)

The receptor for urokinase‐plasminogen activator

Journal of Cellular Biochemistry, 1986
AbstractMany human cells and cell lines possess a specific receptor that binds urokinase plasminogen activator (uPA) with an affinity of about 10−10 M. Bound enzyme is not internalized, is slowly dissociated, and retains its enzymatic activity. The amino acid sequence of uPA responsible for receptor binding is located within the first 35 aminoterminal ...
Francesco Blasi, M. Patrizia Stoppelli, CUBELLIS, MARIA VITTORIA   +2 more
openaire   +3 more sources

Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer

International Journal of Cancer, 1995
AbstractUrokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA mediates its action while attached to a membrane‐bound receptor (uPAR). In this investigation we show that uPAR levels correlate with uPA levels in human breast cancers.
C, Duggan, T, Maguire, E, McDermott, N, O'Higgins, J J, Fennelly, M J, Duffy   +5 more
openaire   +2 more sources

Soluble Urokinase Plasminogen Activator Receptor Is Associated With Subclinical Organ Damage and Cardiovascular Events

Atherosclerosis, 2011
The soluble urokinase plasminogen activator receptor (suPAR) is a plasma marker of low grade inflammation and has been associated with cardiovascular risk.
Allan Linneberg, Ove Andersen, Tine W Hansen   +2 more
exaly   +2 more sources

Regulation of the Urokinase Receptor by Its Plasminogen Activator

Thrombosis and Haemostasis, 1991
SummaryThere is now ample evidence that the proteolytic action of urokinase (UK) is potentiated by a specific cell surface receptor. The present study was undertaken to assess the role of UK as a modulator of its receptor. GEO colonic cells, which secrete relatively low levels of UK (≃0.1 nM/72 h per 106 cells) and display approximately 104 receptors ...
W, Hollas, D, Boyd
openaire   +2 more sources

Immunohistochemical Detection of Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor in Canine Vascular Endothelial Tumours

Journal of Comparative Pathology, 2015
Immunohistochemistry was used to assess the expression of urokinase plasminogen activator (uPA) and uPA receptor (uPAR) in 57 canine primary haemangiosarcomas (HSAs), 26 canine cutaneous haemangiomas (HAs) and in control sections of canine cutaneous granulation tissue.
Sh. Anwar, T. Yanai, H. Sakai
openaire   +2 more sources

Role of plasminogen activators and urokinase receptor in platelet kinetics

The Hematology Journal, 2000
Plasminogen activators (PA) and plasmin are known to affect platelets but little is known of their role in platelet kinetics. We took advantage of genetically deficient mice to explore the role of urokinase (uPA) and tissue type (tPA) PAs, as well as the uPA receptor (uPAR, CD87) in platelet kinetics.Platelet shape and number were investigated by flow ...
Piguet PF, Vesin C, Da Laperousaz C, Rochat A   +3 more
openaire   +3 more sources

Intermolecular Contact Regions in Urokinase Plasminogen Activator Receptor

Journal of Biochemistry, 2003
The glycolipid-anchored urokinase-type plasminogen activator receptor (uPAR) is engaged in various signal transduction events related to cell adhesion, migration and proliferation. In this study, using phage display and peptide array techniques, we have identified several intermolecular contact regions of uPAR.
Olin D, Liang, Khalil, Bdeir, Rachel L, Matz, Triantafyllos, Chavakis, Klaus T, Preissner   +4 more
openaire   +2 more sources

The urokinase receptor and regulation of cell surface plasminogen activation

Cell Differentiation and Development, 1990
Urokinase-type plasminogen activator (u-PA) is a key enzyme involved in migration and invasiveness of cells, both in cancer and in several normal physiological processes (Reich, 1978; Dana et al., 1985; Saksela and Rifkin, 1988; Blasi and Verde, 1990).
Francesco Blasi, CUBELLIS, MARIA VITTORIA, M. Teresa Masucci, Lisbeth B. Møller, David P. Olson, Nina Pedersen, Niels Behrendt, Vincent Ellis, Leif R. Lund, Michael Ploug, Ebbe Rønne, Keld Danø   +11 more
openaire   +3 more sources

Urokinase plasminogen activator receptor levels in Behcet's disease

Thrombosis Research, 2011
To determine urokinase plasminogen activator receptor (uPAR) concentrations in Behcet patients with and without ocular involvement; and to investigate the associations between uPAR levels and clinical manifestations of Behcet's disease.Sixty-four patients with Behcet's disease (31 patients with and 33 patients without ocular involvement) and 23 healthy
Serhat, Birengel, F Nilüfer, Yalçındağ, Ali, Yalçındağ, Esra, Sahli, Figen, Batıoğlu   +4 more
openaire   +2 more sources

Expression of urokinase‐type plasminogen activator, urokinase‐type plasminogen activator receptor, and plasminogen activator inhibitor‐1 and ‐2 in hepatocellular carcinoma

Pathology International, 2000
It has become more and more clear in recent decades that the plasminogen activation system, which includes urokinase‐type plasminogen activator (uPA), urokinase‐type plasminogen activator receptor (uPAR), plasminogen activator inhibitor (PAI)‐1 and PAI‐2, plays a very important role in the aggressiveness of cancer. Using immunohistochemistry and enzyme‐
L, Zhou, Y, Hayashi, T, Itoh, W, Wang, J, Rui, H, Itoh   +5 more
openaire   +2 more sources