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The urokinase plasminogen activator and its receptor

Thrombosis and Haemostasis, 2005
SummaryThe urinary-type plasminogen activator, or uPA, controls matrix degradation through the conversion of plasminogen into plasmin and is regarded as the critical trigger for plasmin generation during cell migration and invasion, under physiological and pathological conditions (such as cancer metastasis).The proteolytic activity of uPA is ...
Alfano D   +9 more
openaire   +5 more sources

A CELLULAR RECEPTOR FOR UROKINASE-TYPE PLASMINOGEN ACTIVATOR

Thrombosis and Haemostasis, 1987
Recent cell biological and biochemical studies on the urokinase-type plasminogen activator (u-PA) have revealed an unsuspected property of this protein: it binds with high affinity and specificity to the plasma membrane of a number of cell types. Hence, while the interaction of tissue-type plasminogen activator (t-PA) with fibrin suggests a preferred ...
Belin, D   +5 more
openaire   +2 more sources

Endogenous Arteriolar Fibrinolysis Requires Urokinase Plasminogen Activator and Leukocyte Urokinase Plasminogen Activator Receptor-1.

Blood, 2006
Abstract Background: In venous thrombi, urokinase associated with leukocytes activates plasminogen to initiate endogenous fibrinolysis. Leukocytes also interact with arteriolar thrombi. Objectives: We hypothesized that urokinase plasminogen activator (uPA) activity would also be delivered to arteriolar thrombi by ...
Xufang Bai, Peter L. Gross
openaire   +1 more source

Hyperglycemia is associated with lower levels of urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor in wound fluid

Journal of Diabetes and its Complications, 2014
Wounds in patients with hyperglycemia show impaired healing. Plasminogen activation is crucial in several overlapping phases of wound healing process. In this study, we aimed i) to compare acute wound fluid in patients with hyperglycemia and normoglycemia, ii) to focus on the elements of plasminogen activation in the wound fluid, and iii) to determine ...
Terzi, Cem   +6 more
openaire   +3 more sources

Characterization of Cell-Associated Plasminogen Activation Catalyzed by Urokinase-Type Plasminogen Activator, but Independent of Urokinase Receptor (uPAR, CD87)

Blood, 1999
The 55-kD urokinase (uPA) receptor (uPAR, CD87) is capable of binding uPA and may be involved in regulating cell-associated plasminogen activation and pericellular proteolysis. While investigating the relationship between uPAR levels and plasmin generation, we found that uPA-catalyzed plasminogen activation is stimulated by cells which do not express ...
C, Longstaff   +3 more
openaire   +2 more sources

Plasminogen Activation by Receptor-Bound Urokinase

Seminars in Thrombosis and Hemostasis, 1991
V, Ellis, K, Danø
openaire   +2 more sources

Urokinase-type plasminogen activator receptor

AfCS-Nature Molecule Pages, 2009
Nicolai Sidenius, Francesco Blasi
openaire   +1 more source

Elevated Soluble Urokinase Plasminogen Activator Receptor (suPAR) in COVID-19 Patients

Clinical Chemistry and Laboratory Medicine, 2021
Giuseppe Lippi   +2 more
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