Results 231 to 240 of about 2,335,681 (277)

The urokinase receptor and integrins in cancer progression

Cellular and Molecular Life Sciences, 2008
Enhanced levels of expression of urokinase receptor (uPAR) and certain integrins have been linked to cancer cell progression. This has classically been attributed to matrix degradation via the activation of the urokinase (uPA)/plasmin system and modulation of cell motility and survival through integrin engagement.
C-H, Tang, Y, Wei
openaire   +2 more sources

Urokinase/Urokinase Receptor-Mediated Signaling in Cancer

2007
Experimental oncogenic transformation or in spontaneous human cancers, mitogenesis and expression of fibrinolytic components such as urokinase (uPA), its receptor (uPAR), and its major inhibitor plasminogen activator inhibtor-1 (PAI-1) or -2 (PAI-2) are activated by common signaling mechanisms.
Sreerama Shetty, Steven Idell
openaire   +1 more source

The urokinase receptor and the regulation of cell proliferation

Thrombosis and Haemostasis, 2005
SummaryThe urokinase receptor is a multifunctional receptor modulating both proteolytic dependent and independent processes. It binds the extracellular proteolytic enzyme urokinase and engages lateral interactions with several transmembrane receptors, including integrins and the EGFR.
Mazzieri, R, Blasi, F
openaire   +3 more sources

Urokinase type plasminogen activator receptor (uPAR) as a new therapeutic target in cancer

Translational medicine @ UniSa, 2016
The urokinase (uPA)-type plasminogen activator receptor (uPAR) is a GPI-anchored receptor that focuses urokinase (uPA) proteolytic activity on the cell surface.
N. Montuori, A. Pesapane, F. Rossi, V. Giudice, A. de Paulis, C. Selleri, P. Ragno   +6 more
semanticscholar   +1 more source

The Urokinase Receptor in the Central Nervous System

CNS & Neurological Disorders - Drug Targets, 2011
The urokinase receptor (uPAR) is a multifunctional glycosylphosphatidylinositol-anchored protein that regulates important processes such as gene expression, cell proliferation, adhesion, migration, invasion, and metastasis. uPAR is an essential component of the plasminogen activation cascade, a protease receptor that binds the urokinase-type ...
Marco, Archinti, Mishan, Britto, Gabriele, Eden, Federico, Furlan, Ronan, Murphy, Bernard, Degryse   +5 more
openaire   +2 more sources

Inhibition of urokinase activity and prevention of urokinase receptor binding by monoclonal antibodies

Journal of Immunological Methods, 1990
Two murine monoclonal antibodies produced against human urokinase-type plasminogen activator were characterized with respect to their antigen-binding specificity and their effects on urokinase activity and urokinase receptor binding. One of the antibodies binds to the protease domain of urokinase (Kass = 2.1 X 10(7) M-1).
U, Zacharias, W, Handschack, F, Schneider, K, Löster, C, Kleitke, F, Noll, H, Will   +6 more
openaire   +2 more sources

Novel Control of Urokinase Receptor Expression

Physiology, 1998
In this section we feature some of the latest and most striking new findings in physiology, interpreting the term “physiology” in its broadest sense. In each instance, an effort will be made to place the new findings in perspective.
openaire   +2 more sources

Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor

Biochemical Journal, 2001
Urokinase (uPA) has the striking ability to cleave its receptor, uPAR, thereby inactivating the binding potential of this molecule. Here we demonstrate that the glycosylphosphatidylinositol (GPI) anchor of uPAR, which is attached to the third domain, is an important determinant in governing this reaction, even though the actual cleavage occurs between ...
Høyer-Hansen, G, Pessara,, Ulrich, Holm, A, Pass, J, Weidle, U., Danø, K, Behrendt, N   +6 more
openaire   +2 more sources

Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer

International Journal of Cancer, 1995
AbstractUrokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA mediates its action while attached to a membrane‐bound receptor (uPAR). In this investigation we show that uPAR levels correlate with uPA levels in human breast cancers.
C, Duggan, T, Maguire, E, McDermott, N, O'Higgins, J J, Fennelly, M J, Duffy   +5 more
openaire   +2 more sources

Urokinase and its Receptor: Markers of Malignancy?

1994
For many years it has been known that abnormal coagulation and fibrinolytic activity existed in the environs of malignant tumours. Whether these activities affected the invasiveness and metastatic activity of tumours has been in question for some time.
P J, Gaffney, D A, Cooke, K G, Burnand
openaire   +2 more sources