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Appeal of Urolithins from Synthesis to Biological Activities
Journal of Agricultural and Food ChemistryUrolithins (Uros), a series of natural polyphenols derived from ellagic acid through gut bacteria metabolism, have gathered significant attention due to their diverse bioactivities such as maintaining mitochondrial health and anti-inflammatory and antioxidative effects. However, the ability to metabolize Uros varies among individuals.
Huanyu Xu, Danyu Lv, Yongguang Guan
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Synthesis of urolithin derivatives and their anti-inflammatory activity
Biochemical and Biophysical Research CommunicationsTwo series of urolithin derivatives, totally 38 compounds, were synthesized. Their anti-inflammatory activity was investigated by detecting the inhibitory effects on the expression of TNF-α in bone marrow-derived macrophages (BMDMs), showing that 24 of 38 ones reduced the expression of TNF-α.
Xintong Li +5 more
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Impact of the Natural Compound Urolithin a on Health, Disease, and Aging
Trends in Molecular Medicine, 2021Pénélope A Andreux +2 more
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Targeting aging with urolithin A in humans
Ageing Research ReviewsUrolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10–1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial ...
Kuerec, Ajla Hodzic +6 more
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Gut Bacteria Involved in Ellagic Acid Metabolism to Yield Human Urolithin Metabotypes Revealed
Journal of Agricultural and Food Chemistry, 2023Francisco A Tomas-Barberan +2 more
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