Results 81 to 90 of about 3,771 (207)
Iranian Journal of Pharmaceutical ResearchBackground: Ellagitannins are well-recognized for their antioxidant, chemopreventive, anti-inflammatory, and neuroprotective efficacy. Due to their poor absorption and extensive catabolism, it is proposed that urolithins, as ellagic acid (EA) metabolites, are the real active molecules exerting these biological functions.
Houssein-Zadeh, Nigar +2 more
openaire +2 more sources
, 2019 Urolithins are bioactive gut microbiota metabolites of ellagic acid. Here, we have identified four unknown urolithins in human feces after the intake of a pomegranate extract. The new metabolites occurred only in 19% of the subjects.
Rocío García-Villalba (2099278) +3 more
core +1 more source
Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers
MedComm, Volume 7, Issue 7, July 2026.This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai +10 more
wiley +1 more source
Metabolic Dysfunction‐Associated Fatty Liver Disease: From Pathogenesis to Treatment
MedComm, Volume 7, Issue 7, July 2026.Extracellular vesicles play a crucial role in interorgan crosstalk of adipose–liver and gut–liver axes and hold potential as therapeutic targets and drug delivery systems for metabolic dysfunction‐associated fatty liver disease (MAFLD). Abbreviations: AT: adipose tissue; EVs: extracellular vesicles; HL: healthy liver; NAFL: nonalcoholic fatty liver ...
Zhifu Cui +5 more
wiley +1 more source
Food and Chemical Toxicology, 2020 The promotion of senescence in cancer cells by dietary (poly)phenols gained attention as a promising chemopreventive strategy against colorectal (CRC) and other cancers. Urolithins (Uros) are ellagitannins and ellagic acid-derived gut microbiota metabolites that reach high concentrations in the human colon.
GIMENEZ BASTIDA, JUAN ANTONIO +3 more
openaire +3 more sources
Osteoarthritis: Epidemiology, Diagnosis, and Treatment
MedComm, Volume 7, Issue 7, July 2026.Osteoarthritis (OA) is a multifactorial degenerative joint disease and a leading cause of disability worldwide. This graphical abstract summarizes the epidemiology, diagnostic strategies, and therapeutic approaches of OA. OA development is driven by aging, metabolic dysregulation, and mechanical stress, leading to progressive joint degeneration ...
Qin Ru +7 more
wiley +1 more source
Targeting aging with urolithin A in humans: A systematic review
Ageing Research ReviewsUrolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10-1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial ...
Kuerec, AH +6 more
openaire +3 more sources
The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome. [PDF]
, 2020 Background & aims: Urolithins are microbial metabolites produced after consumption of ellagitannincontaining foods such as pomegranates and walnuts.
Espín, Juan Carlos +7 more
core +1 more source
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?
Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca +6 more
wiley +1 more source
The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)
Phytotherapy Research, Volume 40, Issue 7, Page 4588-4610, July 2026.The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo +11 more
wiley +1 more source