Results 141 to 150 of about 3,148 (181)

Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment. [PDF]

NPJ Aging
Jara C, Venegas-Zamora L, Park-Kang HS, Lira M, Ricca M, Valenzuela S, Tapia-Rojas C.   +6 more
europepmc   +1 more source

Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial. [PDF]

BMC Med
Domínguez-López I, Galkina P, Fernández-Duval G, Pozzoli C, Razquin C, Jáuregui O, Salas-Salvadó J, Tojal-Sierra L, Fitó M, Corella D, Fiol M, Lapetra J, Gómez-Gracia E, Pintó X, Ruiz-Canela M, Castañer O, Liang L, Sun Q, Serra-Majem L, Ros E, Martínez-González MÁ, Estruch R, Hu FB, Lamuela-Raventós RM.   +23 more
europepmc   +1 more source

Eicosapentaenoic Acid and Urolithin a Synergistically Mitigate Heat Stroke-Induced NLRP3 Inflammasome Activation in Microglial Cells. [PDF]

Nutrients
Cho H, Kim J, Park Y, Kim YC, Chung S.
europepmc   +1 more source

Polyphenols Bioactive Metabolites, and Their Anti-Biofilm and Neuroprotective Potential. [PDF]

Foods
Nazzaro F, Coppola F, Fratianni F, Abdalrazeq M, Ombra MN, De Giulio B, Coppola R, Zengin G.   +7 more
europepmc   +1 more source

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The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention

Current Cancer Drug Targets, 2022
Background: Urolithin A is the metabolite of natural polyphenol ellagic acid and ellagitannins generated by gut microbiota. Urolithin A is better absorbed in the gastrointestinal tract than its parent substances. Thus, the variable effects of ellagitannin-reach food (like pomegranate fruit, walnuts, tea, and others) on people's health might be linked ...

exaly   +3 more sources

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging [PDF]

Trends in Molecular Medicine, 2021
Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its impact on aging and disease been explored.
Penelope Andreux, , Johan Auwerx
exaly   +3 more sources

The Synthesis of Urolithins and their Derivatives and the Modes of Antitumor Action

Mini-Reviews in Medicinal Chemistry, 2023
Abstract: Urolithins are microbial metabolites derived from berries and pomegranate fruits, which display anti-inflammatory, anti-oxidative, and anti-aging activities. There are eight natural urolithins (urolithin A-E, M5, M6 and M7), which have been isolated by now.
Lei Yao, Xiangrong Xu, Zhuanhong Liu
openaire   +2 more sources

Gastrointestinal stability of urolithins: an in vitro approach

European Journal of Nutrition, 2015
Urolithins are bioactive ellagitannin-derived metabolites showing a wide phenotypic variation in their production by the gut microbiota. This work represents a first in vitro step toward the development of new strategies focused on the oral supplementation of urolithins with the aim of overcoming their selective production and making their putative ...
MENA PARRENO, Pedro Miguel, DALL'ASTA, Margherita, CALANI, Luca, BRIGHENTI, Furio, DEL RIO, Daniele   +4 more
openaire   +5 more sources