Results 101 to 110 of about 5,657 (242)
Aging Cell, Volume 25, Issue 9, September 2026.The aging of the human body is a complex process driven by multiple contributing factors. Based on their underlying mechanisms, current anti‐aging interventions can be classified into six primary categories. This paper summarizes the most promising anti‐aging strategies within each class. ABSTRACT The global prevalence of aging and age‐related diseases
Feifei Li +4 more
wiley +1 more source
Clonal Mosaicism of Mitochondrial DNA Heteroplasmy as a Molecular Clock of Aging
Aging Cell, Volume 25, Issue 9, September 2026.Mitochondrial DNA mutations diverge by tissue dynamics across lifespan: dividing tissues accumulate pervasive point mutations via clonal stem‐cell expansion, whereas post‐mitotic tissues harbor clonally expanded large‐scale deletions, both culminating in age‐dependent, threshold‐limited respiratory failure.
Renin Chang +5 more
wiley +1 more source
Nutrition research reviewsThe increasing focus on longevity and cellular health has brought into the spotlight two key compounds, urolithin A (UroA) and spermidine, for their promising roles in autophagy and mitophagy. Urolithin A, a natural metabolite derived from ellagitannins,
Pavel Borsky +7 more
semanticscholar +1 more source
, 2022 Urolithin A is an active compound of gut-microbiota-derived metabolites of polyphenol ellagic acid that has anti-aging, antioxidative, and anti-inflammatory effects.
Chao, Jane C-J +13 more
core +1 more source
Treating age‐related loss of muscle mass and function: Where should we be focusing?
The Journal of Physiology, Volume 604, Issue 17, Page 7059-7075, 1 September 2026.Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham +4 more
wiley +1 more source
Enzyme and Microbial TechnologyUrolithins are metabolites derived from ellagic acid, a compound that is present in many plants, including pomegranate, via the action of gut microorganisms. Among them, urolithin A exhibits antioxidant and anti-inflammatory activity and promotes autophagy, making it a potential contributor to human health.
Anno, Katasho +7 more
openaire +2 more sources
Urolithin A Alleviates Doxorubicin-Induced Senescence in Mesenchymal Stem Cells
The accumulation of senescent cells, characterized by a pro-inflammatory secretory phenotype (SASP), metabolic dysfunction, and irreversible cell cycle arrest, is a driving force behind numerous age-related pathologies and directly undermines the ...
Kalinin, Alexander +7 more
core +1 more source
Urolithin A prevents age-related hearing loss by mitophagy induction in C57BL/6J mice
Figure 1. Effect of Urolithin A (UA) on hearing and the mitochondrial state.Figure 2. Effect of Urolithin A (UA) on expression levels of mitophagy-associated molecules and OXPHOS proteins in the cochlea.Figure 3.
Cho, S (via Mendeley Data)
core +1 more source
Urolithin A prevents age-related hearing loss in C57BL/6J mice likely by mitophagy induction
Figure 1. Effect of Urolithin A (UA) on hearing and the mitochondrial state.Figure 2. Effect of Urolithin A (UA) on expression levels of mitophagy-associated molecules and OXPHOS proteins in the cochlea.Figure 3.
Cho, S (via Mendeley Data), Cho, Sung Il
core +1 more source
Gut microbesAlcohol-related liver disease (ALD) is recognized as a global health crisis, contributing to approximately 20% of liver cancer-associated fatalities.
Hongbo Zhang +8 more
semanticscholar +1 more source