Results 61 to 70 of about 5,657 (242)

Antiatherogenic effects of ellagic acid and urolithins in vitro

Archives of Biochemistry and Biophysics, 2016
Atherosclerosis, one of the leading causes of death worldwide, is characterized by impaired endothelial function and lipid metabolism, among other factors. Ellagitannins are a class of phenolic compounds that may play a role in cardiovascular health. This work aimed to study the potential atheroprotective effects of urolithins, ellagitannin-derived gut
MELE, Laura, MENA PARRENO, Pedro Miguel, PIEMONTESE, Antonio, MARINO, VALENTINA, López Gutiérrez, Noelia, BERNINI, Franco, BRIGHENTI, Furio, ZANOTTI, Ilaria, DEL RIO, Daniele   +8 more
openaire   +3 more sources

Urolithin A provides cardioprotection and mitochondrial quality enhancement preclinically and improves human cardiovascular health biomarkers

iScience
Summary Cardiovascular diseases (CVDs) remain the primary cause of global mortality. Nutritional interventions hold promise to reduce CVD risks in an increasingly aging population. However, few nutritional interventions are proven to support heart health
Sophia Liu, J. Faitg, C. Tissot, D. Konstantopoulos, Ross Laws, G. Bourdier, P. Andreux, Tracey Davey, Hector Gallart-Ayala, J. Ivanisevic, Anurag Singh, C. Rinsch, D. Marcinek, Davide D’Amico   +13 more
semanticscholar   +1 more source

Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica granatum)

Molecules, 2017
Having served as a symbolic fruit since ancient times, pomegranate (Punica granatum) has also gained considerable recognition as a functional food in the modern era. A large body of literature has linked pomegranate polyphenols, particularly anthocyanins
Sheng Wu, Li Tian
doaj   +1 more source

Urolithin Α modulates inter-organellar communication via calcium-dependent mitophagy to promote healthy ageing

Autophagy
Mitochondrial dysfunction and impaired mitophagy are hallmarks of ageing and age-related pathologies. Disrupted inter-organellar communication among mitochondria, endoplasmic reticulum (ER), and lysosomes, further contributes to cellular dysfunction ...
Antonis Roussos, Katerina Kitopoulou, Fivos Borbolis, Christina Ploumi, D. Gianniou, Zhiquan Li, Haijun He, Eleni Tsakiri, Helen Borland, I. Kostakis, M. Samiotaki, I. Trougakos, V. A. Bohr, K. Palikaras   +13 more
semanticscholar   +1 more source

Urolithin A Muscle Endurance in Adults

Researka accepted publication: 1747c75e-7396-47ed-9685-4f97bbb58d86 Source submission: c8408e19-7c24-4e8f-abc2-564ceda228c1 Across these trials, urolithin A improved multiple performance outcomes in middle-aged adults; in older adults, primary walk and
Dominic Lynch
core   +6 more sources

Isolation and characterization of a novel human intestinal Enterococcus faecium FUA027 capable of producing urolithin A from ellagic acid

Frontiers in Nutrition, 2022
Urolithin A (UA) has received considerable research attention because of its health benefits. However, only a few strains have been reported to produce UA from ellagic acid (EA), and the molecular mechanisms underlying the gut microbiota-mediated ...
Xiaomeng Zhang, Xiaomeng Zhang, Xiaomeng Zhang, Yaowei Fang, Yaowei Fang, Yaowei Fang, Guang Yang, Guang Yang, Guang Yang, Xiaoyue Hou, Xiaoyue Hou, Xiaoyue Hou, Yang Hai, Mengjie Xia, Fuxiang He, Yaling Zhao, Yaling Zhao, Yaling Zhao, Shu Liu, Shu Liu, Shu Liu   +20 more
doaj   +1 more source

Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges

Biomedicines
With the global trend of population aging becoming increasingly pronounced, the incidence of central nervous system (CNS) disorders continues to rise, posing a significant challenge to public health systems worldwide.
Qiang Zhang, Wanying Zhang, Xinya Yuan, Xiaohong Peng, Guangyuan Hu   +4 more
semanticscholar   +1 more source

Microbial Phenolic Metabolites in Urine Are Inversely Linked to Certain Features of Metabolic Syndrome in Spanish Adolescents

Antioxidants, 2022
(1) Background: To explore the association between microbial phenolic metabolites (MPM) and metabolic syndrome (MetS) and its clinical features in adolescents aged 12.02 ± 0.41 years. (2) Methods: a cross-sectional study was conducted in 560 participants
Emily P. Laveriano-Santos, Paola Quifer-Rada, María Marhuenda-Muñoz, Camila Arancibia-Riveros, Anna Vallverdú-Queralt, Anna Tresserra-Rimbau, Ana María Ruiz-León, Rosa Casas, Ramon Estruch, Patricia Bodega, Mercedes de Miguel, Amaya de Cos-Gandoy, Jesús Martínez-Gómez, Gloria Santos-Beneit, Juan M. Fernández-Alvira, Rodrigo Fernández-Jiménez, Rosa M. Lamuela-Raventós   +16 more
doaj   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity

Cell Reports Medicine
Summary Constant tumor antigen exposure disrupts chimeric antigen receptor (CAR) T cell metabolism, limiting their persistence and anti-tumor efficacy. To address this, we develop metabolically reprogrammed CAR (MCAR) T cells with enhanced autophagy and ...
A. Akhtar, Md Shakir, Mohammad Sufyan Ansari, Divya, M. I. Faizan, Varnit Chauhan, Aashi Singh, Ruquaiya Alam, Iqbal Azmi, Sheetal Sharma, Mehak Pracha, Insha Mohi Uddin, Uzma Bashir, Syeda Najidah Shahni, Rituparna Ray Chaudhuri, Sarah Albogami, Rik Ganguly, Shakti Sagar, Vijay Pal Singh, G. Kharya, A. K. Srivastava, U. Mabalirajan, Soumya Sinha Roy, Irfan Rahman, Tanveer Ahmad   +24 more
semanticscholar   +1 more source