Results 31 to 40 of about 372 (136)

Pomegranate derivative urolithin A enhances vitamin D receptor signaling to amplify serotonin-related gene induction by 1,25-dihydroxyvitamin D

Biochemistry and Biophysics Reports, 2020
Mediated by the nuclear vitamin D receptor (VDR), the hormonally active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (1,25D), is known to regulate expression of genes impacting calcium and phosphorus metabolism, the immune system, and behavior ...
Sarah Livingston, Sanchita Mallick, Daniel A. Lucas, Marya S. Sabir, Zhela L. Sabir, Hespera Purdin, Sree Nidamanuri, Carol A. Haussler, Mark R. Haussler, Peter W. Jurutka   +9 more
doaj   +1 more source

Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes

Frontiers in Endocrinology, 2022
IntroductionDiabetes is one of the major metabolic diseases worldwide. Despite being a complex systemic pathology, the aggregation and deposition of Islet Amyloid Polypeptide (IAPP), or amylin, is a recognized histopathological marker of the disease ...
Ana F. Raimundo, Ana F. Raimundo, Ana F. Raimundo, Sofia Ferreira, Sofia Ferreira, Sofia Ferreira, Vânia Pobre, Mafalda Lopes-da-Silva, José A. Brito, Daniel J. V. A. dos Santos, Nuno Saraiva, Cláudia N. dos Santos, Cláudia N. dos Santos, Regina Menezes, Regina Menezes, Regina Menezes   +15 more
doaj   +1 more source

Preclinical Evaluation of Oral Urolithin-A for the Treatment of Acute Campylobacteriosis in Campylobacter jejuni Infected Microbiota-Depleted IL-10^−/− Mice

Pathogens, 2020
Human campylobacteriosis represents an infectious enteritis syndrome caused by Campylobacter species, mostly Campylobacter jejuni. Given that C. jejuni infections are rising worldwide and antibiotic treatment is usually not indicated, novel treatment ...
Soraya Mousavi, Dennis Weschka, Stefan Bereswill, Markus M. Heimesaat   +3 more
doaj   +1 more source

Muscadine or amla extracts standardized to ellagic acid content ameliorate glucolipotoxicity associated β-cell dysfunction via inhibition of IL-1β and improved insulin secretion

Food Production, Processing and Nutrition, 2020
Glucolipotocixity induces IL-1 β secretion which impairs pancreatic β-cell insulin secretion. Ellagic acid and urolithin A have strong anti-inflammatory effect on cells. Muscadine and amla are very good sources of ellagic acid. The present study examined
Srikanth Earpina, Karen McDonough, Millicent Yeboah-Awudzi, Kristina J. Cook, Sita Aggarwal, Jack N. Losso   +5 more
doaj   +1 more source

Antiproliferative effect of urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2.2.15 cells by targeting Lin28a/let-7a axis

Brazilian Journal of Medical and Biological Research, 2018
An abnormality in the Lin28/let-7a axis is relevant to the progression of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), which could be a novel therapeutic target for this malignant tumor.
Zhenpeng Qiu, Junxuan Zhou, Cong Zhang, Ye Cheng, Junjie Hu, Guohua Zheng   +5 more
doaj   +1 more source

Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica granatum)

Molecules, 2017
Having served as a symbolic fruit since ancient times, pomegranate (Punica granatum) has also gained considerable recognition as a functional food in the modern era. A large body of literature has linked pomegranate polyphenols, particularly anthocyanins
Sheng Wu, Li Tian
doaj   +1 more source

Design, synthesis, and biological evaluation of urolithin derivatives as potential phosphodiesterase II inhibitors

Journal of Chemical Research, 2023
Urolithins are the gut microbiota metabolites of ellagitannins which are found in natural plants such as pomegranate, strawberry, and raspberry, and in nuts.
Hecheng Wang, Long Tang, Wanhui Di, Feng Yan, Xianfeng Huang, Xiaoqing Feng, Guoqiang Song   +6 more
doaj   +1 more source

The Punicalagin Metabolites Ellagic Acid and Urolithin A Exert Different Strengthening and Anti-Inflammatory Effects on Tight Junction-Mediated Intestinal Barrier Function In Vitro

Frontiers in Pharmacology, 2021
Scope: Ellagitannins are polyphenols found in numerous fruits, nuts and seeds. The elagitannin punicalagin and its bioactive metabolites ellagic acid and urolithins are discussed to comprise a high potential for therapeutically or preventive medical ...
Nina A. Hering, Julia Luettig, Britta Jebautzke, Jörg D. Schulzke, Rita Rosenthal   +4 more
doaj   +1 more source

Urolithin A Protects Ovarian Reserve Via Inhibiting PI3K/Akt Signaling and Preventing Chemotherapy-Induced Follicle Apoptosis

Biology
Urolithin A, which is a natural gut microbial metabolite, exerts multiple beneficial effects upon supplementation, including prolonging lifespan, mitigating diseases, restoring the quality of aged oocytes and alleviating drug toxicity.
Weiyong Wang, Ren Zhou, Yong Ruan, Shuhao Fan   +3 more
doaj   +1 more source

Antiatherogenic effects of ellagic acid and urolithins in vitro

Archives of Biochemistry and Biophysics, 2016
Atherosclerosis, one of the leading causes of death worldwide, is characterized by impaired endothelial function and lipid metabolism, among other factors. Ellagitannins are a class of phenolic compounds that may play a role in cardiovascular health. This work aimed to study the potential atheroprotective effects of urolithins, ellagitannin-derived gut
MELE, Laura, MENA PARRENO, Pedro Miguel, PIEMONTESE, Antonio, MARINO, VALENTINA, López Gutiérrez, Noelia, BERNINI, Franco, BRIGHENTI, Furio, ZANOTTI, Ilaria, DEL RIO, Daniele   +8 more
openaire   +3 more sources