Results 71 to 80 of about 372 (136)

A Mechanism‐Based Framework for Anti‐Aging Strategies: From Metabolic Regulation to Senotherapy and Stem Cell‐Based Interventions

Aging Cell, Volume 25, Issue 9, September 2026.
The aging of the human body is a complex process driven by multiple contributing factors. Based on their underlying mechanisms, current anti‐aging interventions can be classified into six primary categories. This paper summarizes the most promising anti‐aging strategies within each class. ABSTRACT The global prevalence of aging and age‐related diseases
Feifei Li, Yankai Wang, Gelin Wang, Jiguo Chen, Song Huang   +4 more
wiley   +1 more source

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, Volume 604, Issue 17, Page 7059-7075, 1 September 2026.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Urolithin A Exerts Neuroprotective Effects Against Ischemic Stroke by Inhibiting Oxidative Stress and Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Urolithin A (UA) treatment enhances the Nrf2/HO‐1‐mediated antioxidant capacity against ischemic injury postischemic stroke, while also effectively suppressing neuroinflammatory responses. Both of these regulatory effects are likely associated with the NF‐κB signaling pathway, which in turn inhibits neuronal apoptosis and contributes to the improvement
Yanxin Shao, Lina Feng, Yanchun Li, Yichen Cai, Hui Yuan, Qin Tang, Mingfeng Yang, Weixia Yang, Hong Shi, Leilei Mao   +9 more
wiley   +1 more source

Gut microbiota shifts and short‐chain fatty acids alterations in pediatric epilepsy patients on a Mediterranean ketogenic diet

Epileptic Disorders, Volume 28, Issue 4, Page 1159-1174, August 2026.
Abstract Objective The olive oil–based Mediterranean ketogenic diet (MedKD) may support patients with drug‐resistant epilepsy (DRE) or neurometabolic disorders by integrating ketogenic therapy with the cardiometabolic and neuroprotective advantages of the Mediterranean diet.
Sofia Zouganeli, Evdokia K. Mitsou, Mary Yannakoulia, Evangelia Intze, Konstantinos C. Mountzouris, Smaragdi Fessatou, Achilleas Attilakos, Adamantini Kyriacou, Argyrios Dinopoulos   +8 more
wiley   +1 more source

RETRACTED: Kshirsagar et al. A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer’s Disease. Cells 2022, 11, 2660

Cells
The journal retracts the article titled “A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer’s Disease” [...]
Sudhir Kshirsagar, Rainier Vladlen Alvir, Jangampalli Adi Pradeepkiran, Ashly Hindle, Murali Vijayan, Bhagavathi Ramasubramaniam, Subodh Kumar, Arubala P. Reddy, P. Hemachandra Reddy   +8 more
doaj   +1 more source

The role of human microbiota in breast cancer pathogenesis and treatment

iMeta, Volume 5, Issue 4, August 2026.
The human microbiota contributes to breast cancer pathogenesis and treatment response through interactions involving the oral, gut, and breast microbial niches. (Left) Multi‐site dysbiosis is characterized by altered microbial composition and abundance across different anatomical sites.
Jie Qiu, Xiaojia Wang, Man Li, Jing Guo, Shipeng Ning, Yi‐Zhou Gao, Xinyi Zhang, Xuli Meng, Yiding Chen, Yunxiang Zhou   +9 more
wiley   +1 more source

The gut microbiome organ

iMeta, Volume 5, Issue 4, August 2026.
The gut microbiome can be conceptualized as a distributed organ‐like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication with the host. By transforming dietary, host‐derived, and environmental substrates into bioactive metabolites with endocrine‐like, immunomodulatory, and ...
Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu, Krai Daowtak, Xiaotao Shen, Huadong Peng, Jutarop Phetcharaburanin, Huiru Tang, Yulan Wang, Jia V. Li, Mizu Jiang, Nick Powell, Victor W. Zhong, Elaine Holmes, Yunlei Xianyu, Zhigang Liu   +22 more
wiley   +1 more source

Urolithin 9-dehydroxylase from Enterocloster bolteae JCM 12243T catalyzing regiospecific dehydroxylation of urolithins

Enzyme and Microbial Technology
Urolithins are metabolites derived from ellagic acid, a compound that is present in many plants, including pomegranate, via the action of gut microorganisms. Among them, urolithin A exhibits antioxidant and anti-inflammatory activity and promotes autophagy, making it a potential contributor to human health.
Anno, Katasho, Kanako, Kumazawa, Hiroko, Watanabe, Takanori, Nakajima, Natsuno, Chiba, Hiroaki, Yamamoto, Shigenobu, Kishino, Jun, Ogawa   +7 more
openaire   +2 more sources

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source

In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats

Cardiovascular Diabetology, 2017
Background Emerging evidence suggests that specific (poly)phenols may constitute new preventative strategies to counteract cell oxidative stress and myocardial tissue inflammation, which have a key role in the patho-physiology of diabetic cardiomyopathy.
Monia Savi, Leonardo Bocchi, Pedro Mena, Margherita Dall’Asta, Alan Crozier, Furio Brighenti, Donatella Stilli, Daniele Del Rio   +7 more
doaj   +1 more source