Results 111 to 120 of about 5,657 (242)

Microbial method for reproducing the human urolithin metabotypes in vitro and in vivo

, 2022
The present invention relates to a new bacterial strain and a new urolithin named urolithin G. The new strain of the invention is Enterocloster bolteae CEBAS S4A9 DSM 34392 and can customize urolithin production to mimic metabotype A and metabotype B in ...
Beltrán Riquelme, David, Selma, María Victoria, Tomás Barberán, Francisco, García-Villalba, Rocío, Espín de Gea, Juan Carlos   +4 more
core  

In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats

Cardiovascular Diabetology, 2017
Background Emerging evidence suggests that specific (poly)phenols may constitute new preventative strategies to counteract cell oxidative stress and myocardial tissue inflammation, which have a key role in the patho-physiology of diabetic cardiomyopathy.
Monia Savi, Leonardo Bocchi, Pedro Mena, Margherita Dall’Asta, Alan Crozier, Furio Brighenti, Donatella Stilli, Daniele Del Rio   +7 more
doaj   +1 more source

Anti-inflammatory and Antioxidant Mechanism of Urolithin B in Activated Microglia

, 2018
Urolithin B is one of the gut microbial metabolites of ellagitannins, which have a number of biological activities such as anti-cancer, anti-microbial, anti-inflammatory, antioxidant, and neuroprotective effects. Urolithin B showed anti-cancer activities
이경진
core   +1 more source

Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-α-induced inflammation and associated molecular markers in human aortic endothelial cells

, 2012
Numerous in vitro and in vivo studies indicate that ellagitannins exhibit anti-inflammatory, anti-atherosclerotic and anti-angiogenic activity which support their potential preventive effect against cardiovascular diseases.
Larrosa, Mar, Tomás Barberán, Francisco, Giménez-Bastida, J. A., González-Sarrías, Antonio, Espín de Gea, Juan Carlos, García-Conesa, María Teresa   +5 more
core   +1 more source

Urolithin A Hijacks ERK1/2‐ULK1 Cascade to Improve CD8+ T Cell Fitness for Antitumor Immunity

Advancement of science
According to the latest evidence, the microbial metabolite Urolithin A (UA), known for its role in promoting cellular health, modulates CD8+ T cell‐mediated antitumor activity. However, the direct target protein of UA and its underlying mechanism remains
Shuaiya Ma, Qi Wu, Wenxian Wu, Ye Tian, Jie Zhang, Chaojia Chen, Xue Sheng, Fang-Cheng Zhao, Lu Ding, Taixiang Wang, Lai-Xi Zhao, Yu-Ying Xie, Yongxiang Wang, Xuetian Yue, Zhuanchang Wu, Jian Wei, Kun Zhang, Xiaohong Liang, Lifen Gao, Hongyang Wang, Gui-Hua Wang, Chunyang Li, Chun-Hong Ma   +22 more
semanticscholar   +1 more source

Sepsis Induces Long‐Term Muscle and Mitochondrial Dysfunction due to Autophagy Disruption Amenable by Urolithin A

Journal of Cachexia, Sarcopenia and Muscle
Sepsis survivors often experience sustained muscle weakness, leading to physical disability, with no pharmacological treatments available. Despite these well‐documented long‐term clinical consequences, research exploring the cellular and molecular ...
Alexandre Pierre, R. Favory, Benoit Brassart, C. Bourel, Raphael Romien, Sylvain Normandin, Arthur Dubech, C. Vincent, J. Lemaire, Gaëlle Grolaux, Ophélie Not, F. Wallet, Frédéric N Daussin, E. Boulanger, A. Durand, Marie Frimat, A. Ghinet, M. Howsam, W. Laine, Philippe Marchetti, Jérôme Kluza, Estelle Chatelain, Jimmy Vandel, Nicolas Barois, Valérie Montel, Bruno Bastide, S. Preau, Steve Lancel   +27 more
semanticscholar   +1 more source

Induction of autophagy and activation of SIRT-1 deacetylation mechanisms mediate neuroprotection by the pomegranate metabolite urolithin A in BV2 microglia and differentiated 3D human neural progenitor cells [PDF]

, 2019
Scope: Urolithin A is an anti-inflammatory and neuroprotective gut-derived metabolite from ellagitannins and ellagic acid in pomegranate, berries, and nuts. The roles of SIRT-1 and autophagy in the neuroprotective activity of urolithin A are investigated.
El-Bakoush, Abdelmeneim, Olajide, Olumayokun, Harsharan Bhatia, Katola, Folashade, Velagapudi, Ravikanth, El‐Bakoush, Abdelmeneim, Olumayokun A. Olajide, Ravikanth Velagapudi, Abdelmeneim El‐Bakoush, Bhatia, Harsharan, Lepiarz, Izabela, Fiebich, Bernd L., Bhatia, Harsharan S., Katola, Folashade O., Izabela Lepiarz, Folashade O. Katola, Bernd L. Fiebich, Olajide, Olumayokun A.   +17 more
core   +1 more source

Optimization of Medium and Transcriptomic Analysis for Converting Ellagic Acid to Urolithin A by Limosilactobacillus fermentum FUA033

Shipin gongye ke-ji
This study aimed to establish a systematic framework for enhancing the bioconversion efficiency of ellagic acid to urolithin A by Limosilactobacillus fermentum FUA033 through rational medium engineering, while deciphering the molecular orchestration ...
Gewen ZHANG, Liangliang QIAN, Wenmei ZHOU, Yanyan GONG, Tao CHEN, Yingling LIU, Yaowei FANG, Shu LIU   +7 more
doaj   +1 more source

Urolithin A-mediated augmentation of intestinal barrier function through elevated secretory mucin synthesis

Scientific Reports
Maintaining the mucus layer is crucial for the innate immune system. Urolithin A (Uro A) is a gut microbiota-derived metabolite; however, its effect on mucin production as a physical barrier remains unclear.
Takeshi Yasuda, T. Takagi, Kohei Asaeda, Hikaru Hashimoto, M. Kajiwara, Y. Azuma, H. Kitae, Y. Hirai, K. Mizushima, Toshifumi Doi, Ken Inoue, O. Dohi, Naohisa Yoshida, K. Uchiyama, T. Ishikawa, H. Konishi, Yuichi Ukawa, Akiko Kohara, Masatake Kudoh, R. Inoue, Yuji Naito, Yoshito Itoh   +21 more
semanticscholar   +1 more source

Ellagitannins (Ellagic Acid, Urolithin A, Urolithin B) Inhibit the Catalytic Activity of Human Recombinant Metalloproteinase 9

Iranian Journal of Pharmaceutical Research
Background: Ellagitannins are well-recognized for their antioxidant, chemopreventive, anti-inflammatory, and neuroprotective efficacy. Due to their poor absorption and extensive catabolism, it is proposed that urolithins, as ellagic acid (EA) metabolites, are the real active molecules exerting these biological functions.
Houssein-Zadeh, Nigar, Sadeghi, Leila, Dehghan, Gholamreza   +2 more
openaire   +2 more sources