Results 11 to 20 of about 3,474 (131)

Ellagic acid and its fermentative derivative urolithin A show reverse effects on the gp91-phox gene expression, resulting in opposite alterations in all-trans retinoic acid-induced superoxide generating activity of U937 cells

open access: yesBiochemistry and Biophysics Reports, 2021
Ellagitannins (esters composed of glucose and ellagic acid) are hydrolyzed to generate ellagic acid in gut followed by conversion of ellagic acid to urolithins such as urolithin A by intestinal bacteria.
Hidehiko Kikuchi   +3 more
doaj   +1 more source

RETRACTED: A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer’s Disease

open access: yesCells, 2022
In the current study, for the first time, we study mitophagy enhancer urolithin A and a combination of urolithin A+green tea extract EGCG against human Aβ peptide-induced mitochondrial and synaptic, dendritic, inflammatory toxicities and behavioral ...
Sudhir Kshirsagar   +8 more
doaj   +1 more source

Urolithin M5 from the Leaves of Canarium album (Lour.) DC. Inhibits Influenza Virus by Targeting Neuraminidase

open access: yesMolecules, 2022
Ganlanye (GLY), the leaf of Canarium album (Lour.) DC., is a traditional Chinese medicinal herb for warm disease treatment. We found that its aqueous extract could inhibit the influenza A virus.
Mengjie Xiao   +5 more
doaj   +1 more source

Pomegranate Juice Ameliorates Dopamine Release and Behavioral Deficits in a Rat Model of Parkinson’s Disease

open access: yesBrain Sciences, 2021
Pomegranate juice (PJ) is a rich source of ellagitannins (ETs), precursors of colonic metabolite urolithin A, which are believed to contribute to pomegranate’s neuroprotective effect.
Małgorzata Kujawska   +8 more
doaj   +1 more source

Sarcopenia and Muscle Aging: A Brief Overview [PDF]

open access: yesEndocrinology and Metabolism, 2020
The world is facing the new challenges of an aging population, and understanding the process of aging has therefore become one of the most important global concerns.
Tam Dao   +8 more
doaj   +1 more source

Isolation of Human Intestinal Bacteria Capable of Producing the Bioactive Metabolite Isourolithin A from Ellagic Acid

open access: yesFrontiers in Microbiology, 2017
Urolithins are intestinal microbial metabolites produced from ellagitannin- and ellagic acid-containing foods such as walnuts, strawberries, and pomegranates.
María V. Selma   +7 more
doaj   +1 more source

Constituents and Metabolites of a French Oak Wood Extract (Robuvit®) in Serum and Blood Cell Samples of Women Undergoing Hysterectomy

open access: yesFrontiers in Pharmacology, 2020
Ellagitannins are signature constituents of oak wood and their consumption has been associated with various health benefits. In vivo, they undergo metabolic degradation including gut microbial metabolism yielding urolithins.
Linda Volpp   +5 more
doaj   +1 more source

Interactions between Gut Microbiota and Polyphenols: New Insights into the Treatment of Fatigue

open access: yesMolecules, 2022
Fatigue seriously affects people’s work efficiency and quality of life and has become a common health problem in modern societies around the world. The pathophysiology of fatigue is complex and not fully clear.
Chuanhong Luo   +8 more
doaj   +1 more source

Pomegranate derivative urolithin A enhances vitamin D receptor signaling to amplify serotonin-related gene induction by 1,25-dihydroxyvitamin D

open access: yesBiochemistry and Biophysics Reports, 2020
Mediated by the nuclear vitamin D receptor (VDR), the hormonally active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (1,25D), is known to regulate expression of genes impacting calcium and phosphorus metabolism, the immune system, and behavior ...
Sarah Livingston   +9 more
doaj   +1 more source

Urolithins: The Colon Microbiota Metabolites as Endocrine Modulators: Prospects and Perspectives

open access: yesFrontiers in Nutrition, 2022
Selective estrogen receptor modulators (SERMs) have been used in hormone related disorders, and their role in clinical medicine is evolving. Tamoxifen and raloxifen are the most commonly used synthetic SERMs, and their long-term use are known to create ...
Ravindran Vini   +8 more
doaj   +1 more source

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