Results 91 to 100 of about 4,446 (160)

In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats

Cardiovascular Diabetology, 2017
Background Emerging evidence suggests that specific (poly)phenols may constitute new preventative strategies to counteract cell oxidative stress and myocardial tissue inflammation, which have a key role in the patho-physiology of diabetic cardiomyopathy.
Monia Savi, Leonardo Bocchi, Pedro Mena, Margherita Dall’Asta, Alan Crozier, Furio Brighenti, Donatella Stilli, Daniele Del Rio   +7 more
doaj   +1 more source

Urolithin A prevents age-related hearing loss in C57BL/6J mice likely by mitophagy induction

Figure 1. Effect of Urolithin A (UA) on hearing and the mitochondrial state.Figure 2. Effect of Urolithin A (UA) on expression levels of mitophagy-associated molecules and OXPHOS proteins in the cochlea.Figure 3.
Cho, S (via Mendeley Data), Cho, Sung Il
core   +1 more source

Optimization of Medium and Transcriptomic Analysis for Converting Ellagic Acid to Urolithin A by Limosilactobacillus fermentum FUA033

Shipin gongye ke-ji
This study aimed to establish a systematic framework for enhancing the bioconversion efficiency of ellagic acid to urolithin A by Limosilactobacillus fermentum FUA033 through rational medium engineering, while deciphering the molecular orchestration ...
Gewen ZHANG, Liangliang QIAN, Wenmei ZHOU, Yanyan GONG, Tao CHEN, Yingling LIU, Yaowei FANG, Shu LIU   +7 more
doaj   +1 more source

Urolithin A prevents age-related hearing loss by mitophagy induction in C57BL/6J mice

Figure 1. Effect of Urolithin A (UA) on hearing and the mitochondrial state.Figure 2. Effect of Urolithin A (UA) on expression levels of mitophagy-associated molecules and OXPHOS proteins in the cochlea.Figure 3.
Cho, S (via Mendeley Data)
core   +1 more source

Determination of Urolithin A in Health Products by Ultra-High-Performance Liquid Chromatography

Molecules
This study establishes and validates a novel ultra-high-performance liquid chromatography (UHPLC) method for the determination of urolithin A content in health products, a bioactive compound with potential anti-aging properties.
Yue E, Zhuang Wang, Jiahui Nie
doaj   +1 more source

Compositions Comprising Urolithin A And Uses Thereof In Treating Kidney Injury

, 2021
The present disclosure provides nanoparticle compositions comprising i) a polymeric nanoparticle, ii) one or more ligands conjugated to the polymeric nanoparticle, and iii) urolithin A. The disclosure also provides methods and pharmaceutical compositions
Majeti, Naga Vankata Ravi Kumar, Arora, Meenakshi, Ganugula, Raghu, Zou, Dianxiong   +3 more
core  

Chestnut–quebracho tannins shape the fecal metabolome of weaned pigs through microbiota-dependent urolithin production

Journal of Animal Science and Biotechnology
Background Chestnut and quebracho tannins may support gut health in weaned piglets, but their efficacy likely depends on farm environment and microbial capacity to convert tannins into bioactive metabolites. This study evaluated the effects of a blend of
Federico Correa, Diana Luise, Francesco Palumbo, Daniel Scicchitano, Simone Rampelli, Silvia Molino, Nicola Panciroli, Marco Candela, Beatriz Garay-Mayol, María Ángeles Ávila-Gálvez, Antonio González-Sarrías, Andrea Castagnetti, Paolo Trevisi   +12 more
doaj   +1 more source

Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-α-induced inflammation and associated molecular markers in human aortic endothelial cells

, 2012
Numerous in vitro and in vivo studies indicate that ellagitannins exhibit anti-inflammatory, anti-atherosclerotic and anti-angiogenic activity which support their potential preventive effect against cardiovascular diseases.
Larrosa, Mar, Tomás Barberán, Francisco, Giménez-Bastida, J. A., González-Sarrías, Antonio, Espín de Gea, Juan Carlos, García-Conesa, María Teresa   +5 more
core   +1 more source

Urolithin A Modulates PER2 Degradation via SIRT1 and Enhances the Amplitude of Circadian Clocks in Human Senescent Cells [PDF]

Background/Objectives: Circadian clocks are endogenous systems that regulate numerous biological, physiological, and behavioral events in living organisms.
Hideyuki Arie, Daisuke Takemoto, Arie, Hideyuki, Ken-ichi Wakabayashi, Kominami, Masaru, Takemoto, Daisuke, Shinohara, Kazuyuki, Tateishi, Norifumi, Wakabayashi, Ken-ichi, Yasukazu Nakahata, Izumo, Takayuki, Norifumi Tateishi, Rassul Kuatov, Jiro Takano, Takayuki Izumo, Takano, Jiro, Nakamura, Wataru, Yoshihiro Nakao, Nakao, Yoshihiro, Kazuyuki Shinohara, Masaru Kominami, Kuatov, Rassul, Nakahata, Yasukazu, Wataru Nakamura   +23 more
core   +1 more source

Correlation between intestinal microbiota and urolithin metabolism in a human walnut dietary intervention

BMC Microbiology
This study is to investigate the relationship between the intestinal microbiota and urine levels of the ellagic acid-derived polyphenols, the urolithins, in a cohort of subjects following a three-week walnut dietary intervention.
Huijia Liu, John W. Birk, Anthony A. Provatas, Haleh Vaziri, Nuoxi Fan, Daniel W. Rosenberg, Raad Z. Gharaibeh, Christian Jobin   +7 more
doaj   +1 more source