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The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention
Current Cancer Drug Targets, 2022Background: Urolithin A is the metabolite of natural polyphenol ellagic acid and ellagitannins generated by gut microbiota. Urolithin A is better absorbed in the gastrointestinal tract than its parent substances. Thus, the variable effects of ellagitannin-reach food (like pomegranate fruit, walnuts, tea, and others) on people's health might be linked ...
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Gastrointestinal stability of urolithins: an in vitro approach
European Journal of Nutrition, 2015Urolithins are bioactive ellagitannin-derived metabolites showing a wide phenotypic variation in their production by the gut microbiota. This work represents a first in vitro step toward the development of new strategies focused on the oral supplementation of urolithins with the aim of overcoming their selective production and making their putative ...
MENA PARRENO, Pedro Miguel +4 more
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The Synthesis of Urolithins and their Derivatives and the Modes of Antitumor Action
Mini-Reviews in Medicinal Chemistry, 2023Abstract: Urolithins are microbial metabolites derived from berries and pomegranate fruits, which display anti-inflammatory, anti-oxidative, and anti-aging activities. There are eight natural urolithins (urolithin A-E, M5, M6 and M7), which have been isolated by now.
Lei Yao, Xiangrong Xu, Zhuanhong Liu
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Journal of Agricultural and Food Chemistry, 2017
Antimelanogenic agents from natural sources have been widely investigated. Urolithin A (UA) and B (UB), the main gut microflora metabolites of dietary ellagic acid derivatives, have various bioactivities such as anti-inflammatory and antiaging effects.
Shang-Ta Wang +3 more
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Antimelanogenic agents from natural sources have been widely investigated. Urolithin A (UA) and B (UB), the main gut microflora metabolites of dietary ellagic acid derivatives, have various bioactivities such as anti-inflammatory and antiaging effects.
Shang-Ta Wang +3 more
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Research progress of ellagitannin intestinal metabolite urolithins
China Journal of Chinese Materia Medica, 2016Ellagitannins is a kind of phenolic compounds with many biological activities. Recent studies have found that the effective ingredients of these compounds have close relationship with their colon-derived bacteria metabolites, that is urolithins.
Ben-Hong, Zhou +5 more
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Synthesis of urolithin derivatives and their anti-inflammatory activity
Biochemical and Biophysical Research CommunicationsTwo series of urolithin derivatives, totally 38 compounds, were synthesized. Their anti-inflammatory activity was investigated by detecting the inhibitory effects on the expression of TNF-α in bone marrow-derived macrophages (BMDMs), showing that 24 of 38 ones reduced the expression of TNF-α.
Xintong Li +5 more
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Appeal of Urolithins from Synthesis to Biological Activities
Journal of Agricultural and Food ChemistryUrolithins (Uros), a series of natural polyphenols derived from ellagic acid through gut bacteria metabolism, have gathered significant attention due to their diverse bioactivities such as maintaining mitochondrial health and anti-inflammatory and antioxidative effects. However, the ability to metabolize Uros varies among individuals.
Huanyu Xu, Danyu Lv, Yongguang Guan
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Targeting aging with urolithin A in humans
Ageing Research ReviewsUrolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10–1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial ...
Kuerec, Ajla Hodzic +6 more
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