Results 201 to 210 of about 4,989 (225)

Urolithin B protects PC12 cells against glutamate-induced toxicity

Molecular Biology Reports
The involvement of malfunctioning glutamate systems in various central nervous system (CNS) disorders is widely acknowledged. Urolithin B, known for its neuroprotective and antioxidant properties, has shown potential as a therapeutic agent for these disorders.
Israa, Aljabouri, Mehdi, Rostami, Farshad, Mirzavi, Mahla Kazemian, Kakhki, Abbas, Alalikhan, Elaheh, Gheybi, Ali, Hakimi, Mohammad, Soukhtanloo   +7 more
openaire   +2 more sources

Improvement of Urolithin A Yield by In Vitro Cofermentation of Streptococcus thermophilus FUA329 with Human Gut Microbiota from Different Urolithin Metabotypes

Journal of Agricultural and Food Chemistry
Streptococcus thermophilus FUA329 converts ellagic acid (EA) to urolithin A (Uro-A), which is not autonomously converted by the gut microbiota to produce highly bioavailable and multibiologically active Uro-A in urolithin metabotype 0 (UM-0) populations. We consider that Streptococcus thermophilus FUA329 has the potential to be developed as a probiotic.
Mengjie Xia, Ziyan Hua, Yaling Zhao, Gewen Zhang, Xiaoyue Hou, Guang Yang, Shu Liu, Yaowei Fang   +7 more
openaire   +2 more sources

Total Synthesis of Urolithin C 3-Glucuronide

HETEROCYCLES, 2021
Hitoshi Abe, Katsunori Itaya, Ishtiaq Jeelani   +2 more
openaire   +1 more source

Urolithin A alleviates radiation pneumonitis by activating PINK1/PRKN-mediated Mitophagy

International Immunopharmacology
Radiation pneumonitis (RP) is a common and severe complication of radiotherapy, whose pathogenesis involves complex inflammatory responses and cellular damage. Despite its clinical significance, effective treatments remain limited. This study investigates the role of radiation-induced PINK1/PRKN-mediated mitophagy and type I interferon responses in RP ...
Anqi, Zhang, Shilan, Luo, Peng, Li, Lu, Meng, Litang, Huang, Hongxia, Cheng, Chenhui, Zhao, Hongbin, Tu, Xiaomei, Gong   +8 more
openaire   +2 more sources

Targeting aging with urolithin A in humans

Ageing Research Reviews
Urolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10–1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial ...
Kuerec, Ajla Hodzic, Lim, Xuan K., Khoo, Anderson LY, Sandalova, Elena, Guan, Lihuan, Feng, Lei, Maier, Andrea B.   +6 more
openaire   +1 more source

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Trends in Molecular Medicine, 2021
Pénélope A Andreux, Anurag Singh, Johan Auwerx   +2 more
exaly  

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

Cell Reports Medicine, 2022
Anurag Singh, Pénélope A Andreux, William Blanco-Bose   +2 more
exaly  

Ellagic acid and intestinal microflora metabolite urolithin A: A review on its sources, metabolic distribution, health benefits, and biotransformation

Critical Reviews in Food Science and Nutrition, 2023
Shumao Cui, Bingyong Mao, Qiuxiang Zhang
exaly  

Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

Immunity, 2022
Dominic Denk, Angela Braun, Henner F Farin   +2 more
exaly  

Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis

Aging Cell, 2022
Davide D'Amico, Merissa Olmer, Pénélope A Andreux   +2 more
exaly