Results 91 to 100 of about 3,148 (181)

In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats

Cardiovascular Diabetology, 2017
Background Emerging evidence suggests that specific (poly)phenols may constitute new preventative strategies to counteract cell oxidative stress and myocardial tissue inflammation, which have a key role in the patho-physiology of diabetic cardiomyopathy.
Monia Savi, Leonardo Bocchi, Pedro Mena, Margherita Dall’Asta, Alan Crozier, Furio Brighenti, Donatella Stilli, Daniele Del Rio   +7 more
doaj   +1 more source

Transcriptomic Evidence of Mitochondrial Double‐Stranded RNA Accumulation in Brain Aging and Alzheimer's Disease

Aging Cell, Volume 25, Issue 7, July 2026.
Mt‐dsRNA signatures increase in the human brain after midlife in parallel with disrupted mitochondrial RNA homeostasis and are further elevated in Alzheimer's disease, where they correlate with cognitive decline and neuropathology. These findings suggest that age‐related mitochondrial RNA dyshomeostasis may drive chronic inflammation and contribute to ...
Rachel L. Doser, Thomas J. LaRocca
wiley   +1 more source

Urolithins in Human Breast Milk after Walnut Intake and Kinetics of Gordonibacter Colonization in Newly Born: The Role of Mothers’ Urolithin Metabotypes

Journal of Agricultural and Food Chemistry, 2020
The maternal-infant transmission of several urolithins through breast milk and the gut colonization of infants by the urolithin-producing bacterium Gordonibacter during their first year of life were explored. Two trials (proof-of-concept study: n = 11; validation study: n = 30) were conducted, where breastfeeding mothers consumed walnuts as a dietary ...
Cortés-Martín, Adrian, Garcia Villalba, Rocio, García-Mantrana, Izaskun, Rodriguez-Valera, Ana, Romo Vaquero, María, COLLADO, MARIA CARMEN, Espín, Juan Carlos, Tomas-Barberan, Francisco, Selma, Maria Victoria   +8 more
openaire   +4 more sources

Potential of Urolithin A to improve joint health

Aging, 2023
D’Amico, Davide, Lotz, Martin
openaire   +2 more sources

The cGAS-STING signaling pathway is modulated by urolithin A

Mechanisms of Ageing and Development
During aging, general cellular processes, including autophagic clearance and immunological responses become compromised; therefore, identifying compounds that target these cellular processes is an important approach to improve our health span. The innate immune cGAS-STING pathway has emerged as an important signaling system in the organismal defense ...
Madsen, H. B., Park, J. H., Chu, X., Hou, Y., Li, Z., Rasmussen, L. J., Croteau, D. L., Bohr, V. A., Akbari, M.   +8 more
openaire   +5 more sources

Optimization of Medium and Transcriptomic Analysis for Converting Ellagic Acid to Urolithin A by Limosilactobacillus fermentum FUA033

Shipin gongye ke-ji
This study aimed to establish a systematic framework for enhancing the bioconversion efficiency of ellagic acid to urolithin A by Limosilactobacillus fermentum FUA033 through rational medium engineering, while deciphering the molecular orchestration ...
Gewen ZHANG, Liangliang QIAN, Wenmei ZHOU, Yanyan GONG, Tao CHEN, Yingling LIU, Yaowei FANG, Shu LIU   +7 more
doaj   +1 more source

Determination of Urolithin A in Health Products by Ultra-High-Performance Liquid Chromatography

Molecules
This study establishes and validates a novel ultra-high-performance liquid chromatography (UHPLC) method for the determination of urolithin A content in health products, a bioactive compound with potential anti-aging properties.
Yue E, Zhuang Wang, Jiahui Nie
doaj   +1 more source

Effect of Urolithin A on Bovine Sperm Capacitation and In Vitro Fertilization

Animals
Reactive oxygen species (ROS) play a critical role in the functional competence of sperm cells. Conversely, excessive generation of ROS can impair sperm function, including their fertilization ability. Urolithin A (UA), a gut bacteria-derived metabolite produced from the transformation of ellagitannins, with anti-aging and antioxidant properties, was ...
Manuela Jorge, Filipa C. Ferreira, Carla C. Marques, Maria C. Batista, Paulo J. Oliveira, F. Lidon, Sofia C. Duarte, José Teixeira, Rosa M. L. N. Pereira   +8 more
openaire   +3 more sources

Urolithin [PDF]

, 2020
openaire   +1 more source

Development of the Functional Intestinal Metabolite Urolithin A

Nippon Eiyo Shokuryo Gakkaishi, 2023
Yuichi Ukawa, Masatake Kudoh, Shoichi Sawada, Shunsuke Ishiwa, Takanori Nakajima   +4 more
openaire   +1 more source