Results 201 to 210 of about 4,964 (226)

Appeal of Urolithins from Synthesis to Biological Activities

Journal of Agricultural and Food Chemistry
Urolithins (Uros), a series of natural polyphenols derived from ellagic acid through gut bacteria metabolism, have gathered significant attention due to their diverse bioactivities such as maintaining mitochondrial health and anti-inflammatory and antioxidative effects. However, the ability to metabolize Uros varies among individuals.
Huanyu Xu, Danyu Lv, Yongguang Guan
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Colon Cancer Chemopreventive Activities of Pomegranate Ellagitannins and Urolithins

Journal of Agricultural and Food Chemistry, 2010
Pomegranate juice derived ellagitannins and their intestinal bacterial metabolites, urolithins, inhibited TCDD-induced CYP1-mediated EROD activity in vitro with IC(50) values ranging from 56.7 microM for urolithin A to 74.8 microM for urolithin C.
Sashi G, Kasimsetty, Dobroslawa, Bialonska, Muntha K, Reddy, Guoyi, Ma, Shabana I, Khan, Daneel, Ferreira   +5 more
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Targeting aging with urolithin A in humans

Ageing Research Reviews
Urolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10–1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial ...
Kuerec, Ajla Hodzic, Lim, Xuan K., Khoo, Anderson LY, Sandalova, Elena, Guan, Lihuan, Feng, Lei, Maier, Andrea B.   +6 more
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Neuroprotective Attributes of Gut-derived Urolithins in Parkinson’s Disease

Molecular Neurobiology
Urolithins, a class of gut microbiota-derived metabolites, are produced from dietary ellagitannins and ellagic acid. Their pleiotropic activities, including antioxidant, anti-inflammatory, and mitophagy-enhancing effects, position them as promising candidates for Parkinson's disease (PD), a disorder increasingly understood through the lens of gut-brain
Sushila, Chhetry, Abhideep, Roy, Rubina, Roy, Pallab, Bhattacharya, Victor, Tapias, Anupom, Borah   +5 more
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Neuroprotective effects of urolithin a in a mouse model of intracerebral hemorrhage

Neuropharmacology
Intracerebral hemorrhage (ICH) accounts for 10-15 % of all stroke cases and is associated with high mortality and morbidity. Brain injury caused by ICH includes primary and secondary brain injury. Neuroinflammation and apoptosis play important roles in the pathological process of secondary brain injury after ICH.
Yan Guo, Xiangyu Zhang, Jianzhong Deng, Qiuyang Su, Yuanyuan Liu, Gaili Yan, Sara Xue, V. Wee Yong, Mengzhou Xue   +8 more
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Improvement of Urolithin A Yield by In Vitro Cofermentation of Streptococcus thermophilus FUA329 with Human Gut Microbiota from Different Urolithin Metabotypes

Journal of Agricultural and Food Chemistry
Streptococcus thermophilus FUA329 converts ellagic acid (EA) to urolithin A (Uro-A), which is not autonomously converted by the gut microbiota to produce highly bioavailable and multibiologically active Uro-A in urolithin metabotype 0 (UM-0) populations. We consider that Streptococcus thermophilus FUA329 has the potential to be developed as a probiotic.
Mengjie Xia, Ziyan Hua, Yaling Zhao, Gewen Zhang, Xiaoyue Hou, Guang Yang, Shu Liu, Yaowei Fang   +7 more
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NMR Spectroscopic Identification of Urolithin G, a Novel Trihydroxy Urolithin Produced by Human Intestinal Enterocloster Species

Journal of Agricultural and Food Chemistry, 2023
Rocio García-Villalba, Juan Carlos Espin, Maria V Selma   +2 more
exaly  

Urolithin A Produced by Novel Microbial Fermentation Possesses Anti-aging Effects by Improving Mitophagy and Reducing Reactive Oxygen Species in Caenorhabditis elegans

Journal of Agricultural and Food Chemistry, 2023
Shumao Cui, Bingyong Mao, Qiuxiang Zhang   +2 more
exaly  

Gut Bacteria Involved in Ellagic Acid Metabolism To Yield Human Urolithin Metabotypes Revealed

Journal of Agricultural and Food Chemistry, 2023
Carlos E Iglesias-Aguirre, Rocio García-Villalba, Juan Carlos Espin   +2 more
exaly  

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

Cell Reports Medicine, 2022
Anurag Singh, Davide D’Amico, Penelope A Andreux   +2 more
exaly