Results 91 to 100 of about 23,614 (207)
Journal of Lipid Research, 2000 The role of long-chain polyunsaturated fatty acids (PUFA) in the etiopathology and treatment of cancer is poorly understood. We have studied the effects of n–3 and n–6 PUFA on the proliferation and survival of normal human uroepithelial (NHU) cells ...
Christine P. Diggle +4 more
doaj +1 more source
Microbiome‐urothelium crosstalk in bladder cancer: From dysbiosis to clinical translation
iMetaOmics, Volume 3, Issue 1, March 2026.This review elucidates the critical crosstalk between the urobiome and bladder cancer (BCa), mapping the landscape from ecological dysbiosis to clinical translation. We synthesize emerging evidence on microbial signatures that distinguish BCa patients, exploring key carcinogenic mechanisms including chronic inflammation, genotoxicity, and the gut ...
Haoxiang Xu +14 more
wiley +1 more source
Marine Drugs, 2009 The objective of this exploratory, open-label, single-arm, phase II clinical trial was to evaluate plitidepsin (5 mg/m2) administered as a 3-hour continuous intravenous infusion every two weeks to patients with locally advanced/metastatic transitional ...
Sergio Szyldergemajn +8 more
doaj +1 more source
Novel Method of Plasmid DNA Delivery to Mouse Bladder Urothelium by Electroporation. [PDF]
, 2018 Genetically engineered mouse models (GEMMs) are extremely valuable in revealing novel biological insights into the initiation and progression mechanisms of human diseases such as cancer.
Liu, Yueli +3 more
core +2 more sources
Urothelial Proteome Changes Underlying Overactive Bladder Associated With Bladder Outlet Obstruction [PDF]
International Neurourology JournalPurpose Overactive bladder (OAB) in men with bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH) represents a major therapeutic challenge, as symptoms often persist even after surgical relief of obstruction.
Sang-Yeop Lee +8 more
doaj +1 more source
Impacts of chronic stress on urinary bladder function & recovery through modification of PACAP signaling [PDF]
, 2016 Stress can cause or contribute to bladder dysfunction though specific effects remain unclear. Individuals with interstitial cystitis (IC)/bladder pain syndrome (BPS) experience increased symptom severity with stress, including pain and increased urgency ...
Mathews, Morgan E
core +1 more source
Pathophysiology of the urothelium and detrusor [PDF]
Canadian Urological Association Journal, 2011 Conventional wisdom now agrees that symptoms of overactivebladder (OAB) seem to emanate from an aberration in the voidingreflex, leading to involuntary detrusor contractions of eitherneurogenic or myogenic origin. Furthermore, emerging evidencealso encourages us to adopt a new paradigm, in which bladderurothelium is not just a simple barrier but an ...
openaire +3 more sources
Bilateral tumors of the upper urothelium
Srpski arhiv za celokupno lekarstvo, 2006 Introduction: The incidence of tumors of the upper urothelium is high in our country, apart from their relation to specific regions (BEN and PBEN) and their frequent bilateralism. Bilateral forms are present in significant percentage and are followed, in most cases, by renal failure, which speaks in favor of conservative surgery, if possible. Objective:
Đokić Milan +4 more
openaire +4 more sources
P2X₃ Knock-Out Mice Reveal a Major Sensory Role for Urothelially Released ATP [PDF]
, 2001 The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using P2X₃ receptor knock-out (P2X₃ ⁻⁄⁻) and wild-type control (P2X₃ ⁺⁄⁺) mice.
Bardini, M +7 more
core
CellsUncovering the function of understudied G protein-coupled receptors (GPCRs) provides a wealth of untapped therapeutic potential. The poorly understood adhesion GPCR Gpr126 (Adgrg6) is widely expressed in developing kidneys.
Peter Kösters +6 more
doaj +1 more source