Results 81 to 90 of about 4,974 (168)

The Botulinum Treatment of Neurogenic Detrusor Overactivity: The Double-Face of the Neurotoxin

Toxins, 2019
Botulinum neurotoxin (BoNT) can counteract the highly frequent involuntary muscle contractions and the uncontrolled micturition events that characterize the neurogenic detrusor overactivity (NDO) due to supra-sacral spinal cord lesions.
Chiara Traini, Maria Giuliana Vannucchi
doaj   +1 more source

Update on cellular expression and function of ANO1 channels in urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley   +1 more source

Acellular foreskin dermal matrix is efficient in supporting the growth of urothelial cells derived from hypospadias patients

Frontiers in Pediatrics
IntroductionHypospadias is a common congenital defect in males, with surgery remaining the primary treatment option. However, urethral reconstruction procedures often require additional tissue transplantation, which is limited by the availability of ...
Zhiqing Cao, Zhenwei Yang, Qunfang Ye, Juntan Xiong, Aozhou Zhu   +4 more
doaj   +1 more source

Myostatin‐dependent detrusor remodelling mediates contractility impairment in diabetic rats’ bladder – a maximal elastance analysis

The Journal of Physiology, EarlyView.
Abstract figure legend In the muscular layer of long‐standing diabetic bladders increased myostatin expression promotes tissue remodelling by reducing the muscle‐to‐collagen ratio, ultimately diminishing bladder contractility. Maximal elastance – defined as the slope of the end‐emission pressure–volume relationship (EPR), derived from the regression ...
Cheng‐Yuan Lai, Hui‐Hsuan Lau, Ming‐Chun Hsieh, Hsien‐Yu Peng, Dylan Chou, Tsung‐Hsien Su, Tzer‐Bin Lin   +6 more
wiley   +1 more source

Paraurethral Endometrioid Carcinoma Arising From Ectopic Endometriosis: A Case Report

IJU Case Reports, Volume 9, Issue 6, November 2026.
ABSTRACT Introduction Malignant transformation of endometriosis is rare and most commonly involves the ovary; transformation from paraurethral endometriosis is exceedingly rare. Case Presentation A 73‐year‐old postmenopausal woman with prior ovarian endometrioma presented with dysuria and voiding difficulty.
Keita Ogasawara, Takashi Tsuyukubo, Mizuki Hisano, Hiromitsu Fujisawa, Shigekatsu Maekawa, Mitsugu Kanehira, Mitsumasa Osakabe, Naoki Yanagawa, Hiroaki Itamochi, Wataru Obara   +9 more
wiley   +1 more source

The bladder urothelium: passive permeability and intravesical drug passive diffusion

, 2005
The urothelium allows the urinary bladder to minimize alterations in the composition of the urine during storage. Modifications of either cellular or tight junctions permeability alter the efficacy of the barrier properties of urothelium.
Di Stasi Savino M, Nardicchi Vincenza, Giannantoni Antonella., Porena Massimo, Mearini Ettore, Goracci Gianfrancesco   +5 more
core   +2 more sources

PPARγ promotes urothelial remodeling during urinary tract obstruction

Experimental and Molecular Medicine
Urinary tract obstruction (UTO) is a common cause of kidney injury that can result in chronic kidney disease and end-stage renal disease. Heterogeneity in the extent of obstructive renal damage in humans with UTO implies the existence of unknown ...
Mohammad El-Harakeh, Felipe Rodriguez-Tirado, Andrew J. Hardman, Alexa Miehls, Oumoulkhairy Camara, Kelly M. Grounds, Glenis Tocaj, Macie Kercsmar, Birong Li, Xin Wang, Brian Becknell, Ashley R. Jackson   +11 more
doaj   +1 more source

Paclitaxel with Cisplatin as Salvage Treatment for Patients with Previously Treated Advanced Transitional Cell Carcinoma of the Urothelial Tract

Neoplasia: An International Journal for Oncology Research, 2007
BACKGROUND: This study was performed to evaluate the safety and efficacy of paclitaxel with cisplatin as salvage therapy in patients previously treated with gemcitabine and cisplatin (G/C) for advanced transitional cell carcinoma (TCC) of the urothelial ...
Ji Eun Uhm, Ho Yeong Lim, Won Seog Kim, Han Yong Choi, Hyun Moo Lee, Byeong-Bae Park, Keunchil Park, Won Ki Kang   +7 more
doaj   +1 more source

Modeling Catheter‐Associated Bladder Mucosal Adhesion and Microtrauma Using a Human Urothelial Microtissue Model

Advanced NanoBiomed Research, Volume 6, Issue 10, October 2026.
Intermittent catheter use can damage the urinary tract and predispose to infection. We deployed a complex human urothelial model to investigate. Catheter contact induced compressive and shear stress causing umbrella cell disruption, reduced barrier function, inflammation and increased cell adhesion to the catheter surface.
Nazila V. Jafari, Jennifer L. Rohn
wiley   +1 more source

Mechanotransduction in the urothelium: ATP signalling and mechanoreceptors

, 2023
The urothelium, which covers the inner surface of the bladder, is continuously exposed to a complex physical environment where it is stimulated by, and responds to, a wide range of mechanical cues. Mechanically activated ion channels endow the urothelium
Junwei Hu, Ping Yin, Xu Li, Lumin Liu, Yuelai Chen   +4 more
core   +1 more source