Results 91 to 100 of about 4,974 (168)

Age- and Urothelium-related Changes in Hydrogen Sulfide-induced Responses in Mouse Bladder

Journal of Physiological Investigation
The alterations in bladder function are associated with aging. Hydrogen sulfide (H2S) is a gaseous neurotransmitter that is synthesized in the urinary bladder and is suggested to regulate bladder smooth muscle tone.
Fatma Aydinoglu, Tugba Toyran, Nuran Ogulener   +2 more
doaj   +1 more source

INtraVESical immunoTherapy (INVEST) prior to radical cystectomy for bladder cancer: trial protocol

BJU International, Volume 138, Issue 4, Page 607-619, October 2026.
Background High‐risk non‐muscle‐invasive bladder cancer (HRNMIBC) has a variable prognosis, managed predominantly by local surgical resection and intravesical Bacillus Calmette–Guérin (BCG), or radical cystectomy (RC). Current treatments are poorly tolerated, have supply limitations and often fail to control the disease.
Ruby Lister‐Whelan, Ethan Senior, Jessica Kendall, Jamie B. Oughton, Fiona Collinson, Jon Griffin, Rachel Hubbard, Steven Kennish, Aidan Noon, Derek J. Rosario, Irbaz B. Riaz, Julie Telliez, James W. F. Catto, Syed A. Hussain   +13 more
wiley   +1 more source

Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy. [PDF]

, 2017
CONTEXT Urothelial carcinoma is considered a pan-urothelial disease. As such, the remnant urothelium in the upper urinary tract and urethra following radical cystectomy (RC) remains at risk for secondary urothelial tumors (SUTs).
Gakis, Georgios, Black, Peter C, Stenzl, Arnulf, Bochner, Bernard H, Kassouf, Wassim, Boorjian, Stephen A, Thalmann, George   +6 more
core   +1 more source

N–3 and n–6 polyunsaturated fatty acids induce cytostasis in human urothelial cells independent of p53 gene function

Journal of Lipid Research, 2000
The role of long-chain polyunsaturated fatty acids (PUFA) in the etiopathology and treatment of cancer is poorly understood. We have studied the effects of n–3 and n–6 PUFA on the proliferation and survival of normal human uroepithelial (NHU) cells ...
Christine P. Diggle, Eva Pitt, Paul Roberts, Ludwik K. Trejdosiewicz, Jennifer Southgate   +4 more
doaj   +1 more source

IS THE URINARY TRACT EPITHELIUM TALENTED AS THE RENAL TUBULAR EPITHELIUM ?

Turkish Journal of Nephrology, 2019
The urothelium serves as a barrier and a storage functions due to the specialized structure of the superficial cells and junctional complexes, while maintaining the urine composition similar to that generated by kidneys.
Dilek GÜNEŞ, Salih KAVUKÇU
doaj  

Phase II Study of Biweekly Plitidepsin as Second-Line Therapy for Advanced or Metastatic Transitional Cell Carcinoma of the Urothelium

Marine Drugs, 2009
The objective of this exploratory, open-label, single-arm, phase II clinical trial was to evaluate plitidepsin (5 mg/m2) administered as a 3-hour continuous intravenous infusion every two weeks to patients with locally advanced/metastatic transitional ...
Sergio Szyldergemajn, Jean P. Droz, Sonia Extremera, Patrick Schöffski, Joan Carles Galceran, Enrique Gallardo, Stephane Culine, Aude Fléchon, Herlinde Dumez   +8 more
doaj   +1 more source

Urothelial Proteome Changes Underlying Overactive Bladder Associated With Bladder Outlet Obstruction [PDF]

International Neurourology Journal
Purpose Overactive bladder (OAB) in men with bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH) represents a major therapeutic challenge, as symptoms often persist even after surgical relief of obstruction.
Sang-Yeop Lee, Ji Yong Lee, Sung Ho Yun, Minji Lee, Dong-Eon Lee, Ji-Hyeon Min, Chung Lyul Lee, Gun-Hwa Kim, Ju Hyun Shin   +8 more
doaj   +1 more source

Heterogeneity of uroplakin localization in human normal urothelium, papilloma and papillary carcinoma [PDF]

, 2013
Background. Uroplakins are differentiation-related membrane proteins of urothelium. We compared uroplakin expression and ultrastructural localization in human normal urothelium, papilloma and papillary carcinoma.
Zupančič, Daša, Romih, Rok
core   +1 more source

Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys

Cells
Uncovering the function of understudied G protein-coupled receptors (GPCRs) provides a wealth of untapped therapeutic potential. The poorly understood adhesion GPCR Gpr126 (Adgrg6) is widely expressed in developing kidneys.
Peter Kösters, Salvador Cazorla-Vázquez, René Krüger, Christoph Daniel, Eva Vonbrunn, Kerstin Amann, Felix B. Engel   +6 more
doaj   +1 more source

The role of the urothelium in mediating bladder responses to isoprenaline

, 2006
OBJECTIVES To investigate whether the responses of the pig bladder to isoprenaline (a nonselective β-adrenoceptor agonist) are influenced by the presence of an intact urothelium and whether any influence might be attributed to the release of nitric ...
Sellers, D. J., Murakami, Shigetaka, Chess-Williams, R., Murakami, S., Chapple, C. R., Akino, H., Akino, Hironobu, Chapple, Christopher R., Sellers, Donna J., Chess-Williams, Russell   +9 more
core   +1 more source