Results 61 to 70 of about 14,292 (181)

FGF7 peptide (FGF7p) mimetic mitigates bladder urothelial injury from cyclophosphamide

Physiological Reports, 2022
Although full‐length fibroblast growth factor 7 (FGF7) blocks cyclophosphamide‐induced urothelial apoptosis in mice, limitations include high production costs because of its large size.
Sridhar Tatarao Narla, Lori Rice, David Ostrov, Steven G. Swarts, Dietmar W. Siemann, Daniel Scott Bushnell, Jacqueline G. Holden, Joanne Lindsey Duara, Carlton Matthew Bates   +8 more
doaj   +1 more source

Pre‐clinical evaluation of a laser system with emission control based on stone vs soft tissue recognition

BJU International, EarlyView.
Objective To evaluate the feasibility and performance of the StoneSense™ module (SSM; IPG Medical, Marlborough, MA, USA), a prototype real‐time target recognition unit integrated into a IPG Thulium Fiber Laser (TFL). Materials and Methods The SSM analyses the spectral signature of back reflected light‐emitting diode (LED) light from the target ...
Olivier Traxer, Federico Zorzi, IIya V. Yaroslavsky, Anastasia Kovalenko, Viktoriya Andreeva, James Childs, Alexey G. Martov, Gregory Altshuler   +7 more
wiley   +1 more source

Tumorigenicity of RTK/RAS in urothelium

Oncoscience, 2015
Although bladder cancer (BC) was the cancer from which the first human oncogene, RAS, was identified, questions persisted over the past 35 years as to whether RAS activation in urothelium was tumorigenic [1]. This was due in large part to the relatively low frequency (~15%) and lack of grade and stage association of RAS mutations in human BC [2 ...
Xue-Ru, Wu, Cathy, Mendelsohn, David J, DeGraff   +2 more
openaire   +2 more sources

Urothelial Senescence in the Pathophysiology of Diabetic Bladder Dysfunction—A Novel Hypothesis

Frontiers in Surgery, 2018
Diabetic bladder dysfunction (DBD) is a well-recognized and common symptom affecting up to 50% of all diabetic patients. DBD has a broad range of clinical presentations ranging from overactive to underactive bladder symptoms that develops in middle-aged ...
Nicole S. Klee, Cameron G. McCarthy, Steven Lewis, Jaine L. McKenzie, Jaine L. McKenzie, Julie E. Vincent, R. Clinton Webb   +6 more
doaj   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, EarlyView.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

FOXA1 is a highly sensitive diagnostic marker for prostate cancer including small cell carcinoma of the prostate

Histopathology, EarlyView.
FOXA1 is a highly sensitive diagnostic marker for prostate cancer. Besides prostatic adenocarcinoma, it is also expressed in 57%–80% of metastatic or primary prostatic small cell carcinomas, which lose traditional prostatic markers including NKX3.1. Although it is less specific than NKX3.1, it can serve as a valuable adjunct for confirming prostatic ...
Jianping Zhao, Jun Yao, Hossein Hosseini, Ezra Baraban, Ruihe Lin, Charles C. Guo, Lei Huo, Wei Lu, Khaja Khan, Shufang Wang, Luisa Maren Solis Soto, Qingqing Ding   +11 more
wiley   +1 more source

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source

Intravesical Botox: An Effective Therapy for Refractory Monosymptomatic Nocturnal Enuresis

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim Monosymptomatic nocturnal enuresis (MNE) significantly impacts many children, with substantial patient groups refractory to conventional first‐line treatments. Intravesical Botox is used for various refractory functional voiding disorders in children, but its efficacy in MNE has not been widely established.
Eliza Szwarcberg, Chris Kimber, Kiarash Taghavi   +2 more
wiley   +1 more source

Bilateral tumors of the upper urothelium

Srpski arhiv za celokupno lekarstvo, 2006
Introduction: The incidence of tumors of the upper urothelium is high in our country, apart from their relation to specific regions (BEN and PBEN) and their frequent bilateralism. Bilateral forms are present in significant percentage and are followed, in most cases, by renal failure, which speaks in favor of conservative surgery, if possible. Objective:
Đokić Milan, Dragičević Dejan, Nikolić Jovan, Dragićević Svetomir, Radivojević Dragana   +4 more
openaire   +4 more sources

What Do We Know About Cyclooxygenases Expression in the Lower Urinary Tract of Dogs and Cats? A Systematic Review

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Cyclooxygenases (COX‐1 and COX‐2) are key enzymes in the biosynthesis of prostanoids, which mediate physiological functions, inflammation, and the process of carcinogenesis. In dogs and cats, lower urinary tract diseases are prevalent and often complex, requiring targeted therapeutic interventions.
Reiner Silveira de Moraes, Luíz Guilherme Dércore Benevenuto, Ana Giulia Gabriel da Rocha Cesario, Julia Franco Ferreira, Suellen Rodrigues Maia, Doughlas Regalin, Dirceu Guilherme de Souza Ramos, Alessandra Melchert, Priscylla Tatiana Chalfun Guimarães‐Okamoto   +8 more
wiley   +1 more source