Results 1 to 10 of about 20,028 (196)

Ursolic acid enhances macrophage autophagy and attenuates atherogenesis [PDF]

Journal of Lipid Research, 2016
Macrophage autophagy has been shown to be protective against atherosclerosis. We previously discovered that ursolic acid (UA) promoted cancer cell autophagy.
Fan, Daping, Iwanowycz, Stephen, Leng, Shuilong, Razani, Babak, Saaoud, Fatma, Sergin, Ismail, Wang, Junfeng, Wang, Yuzhen   +7 more
core   +6 more sources

Ursolic Acid Inhibits Collagen Production and Promotes Collagen Degradation in Skin Dermal Fibroblasts: Potential Antifibrotic Effects [PDF]

Biomolecules
Tissue fibrosis, characterized by excessive collagen accumulation, leads to impaired organ function and is a hallmark of various chronic diseases. Fibroblasts play a central role in collagen production and deposition.
Tianyuan He, Yaping Xiang, Hehui Quan, Yingchun Liu, Chunfang Guo, Taihao Quan   +5 more
doaj   +2 more sources

Extraction and Purification of Ursolic Acid from the Apple Peel and in vitro Assessment of the Biochemical Antibacterial, Antioxidant and Wound Healing Characteristics

Applied Food Biotechnology, 2021
Background and Objective: Ursolic acid is a pentacyclic triterpenoid with various biological characteristics. The objective of this study was to investigate potentially biological activities of ursolic acid extracted from apple peels.
Fatemeh Ghasemzadeh, Ghasem Najafpour Darzi, Maedeh Mohammadi   +2 more
doaj   +1 more source

Anti-inflammatory and antioxidant activity of ursolic acid: a systematic review and meta-analysis

Frontiers in Pharmacology, 2023
Introduction: There is currently evidence suggesting that ursolic acid may exert a favorable influence on both anti-inflammatory and antioxidant impact.
Man Zhao, Fengyang Wu, Zhaohong Tang, Xinyu Yang, Yanhua Liu, Fengxia Wang, Baojiang Chen   +6 more
doaj   +1 more source

Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling

Frontiers in Oncology, 2021
Breast cancer remains the most common malignancy and the leading causality of cancer-associated mortality among women worldwide. With proven efficacy, Oldenlandia diffusa has been extensively applied in breast cancer treatment in Traditional Chinese ...
Shengqi Wang, Shengqi Wang, Shengqi Wang, Shengqi Wang, Shengqi Wang, Shengqi Wang, Xu Chang, Juping Zhang, Juping Zhang, Juping Zhang, Juping Zhang, Jing Li, Jing Li, Jing Li, Jing Li, Neng Wang, Neng Wang, Neng Wang, Neng Wang, Neng Wang, Bowen Yang, Bowen Yang, Bowen Yang, Bowen Yang, Bo Pan, Bo Pan, Bo Pan, Bo Pan, Yifeng Zheng, Yifeng Zheng, Yifeng Zheng, Yifeng Zheng, Xuan Wang, Xuan Wang, Xuan Wang, Xuan Wang, Hesheng Ou, Zhiyu Wang, Zhiyu Wang, Zhiyu Wang, Zhiyu Wang   +40 more
doaj   +1 more source

Ursolic Acid Impairs Cellular Lipid Homeostasis and Lysosomal Membrane Integrity in Breast Carcinoma Cells

Cells, 2022
Cancer is one of the leading causes of death worldwide, thus the search for new cancer therapies is of utmost importance. Ursolic acid is a naturally occurring pentacyclic triterpene with a wide range of pharmacological activities including anti ...
Ditte L. Fogde, Cristina P. R. Xavier, Kristina Balnytė, Lya K. K. Holland, Kamilla Stahl-Meyer, Christoffel Dinant, Elisabeth Corcelle-Termeau, Cristina Pereira-Wilson, Kenji Maeda, Marja Jäättelä   +9 more
doaj   +1 more source

Effect of Anti-Obesity and Antioxidant Activity through the Additional Consumption of Peel from ‘Fuji’ Pre-Washed Apple

Foods, 2022
There is limited information on the health effects of apple peel taken from ‘Fuji’ (Malus pumila Mill) apples washed with ozonated water. To clarify the health-promoting effects of peel, the triterpenoids (ursolic acid and oleanolic acid) were quantified
Da-Yeong Ko, Kang-Mo Ku
doaj   +1 more source

Ursolic Acid Targets Glucosyltransferase and Inhibits Its Activity to Prevent Streptococcus mutans Biofilm Formation

Frontiers in Microbiology, 2021
Streptococcus mutans (S. mutans), the prime pathogen of dental caries, can secrete glucosyltransferases (GTFs) to synthesize extracellular polysaccharides (EPSs), which are the virulence determinants of cariogenic biofilms.
Yucui Liu, Yucui Liu, Yanxin Huang, Cong Fan, Cong Fan, Zhongmei Chi, Miao Bai, Luguo Sun, Li Yang, Chunlei Yu, Zhenbo Song, Xiaoguang Yang, Xiaoguang Yang, Jingwen Yi, Jingwen Yi, Shuyue Wang, Lei Liu, Guannan Wang, Lihua Zheng   +18 more
doaj   +1 more source

Fruit characteristics and cuticle triterpenes as related to postharvest quality of highbush blueberries [PDF]

, 2016
Chilean fresh blueberries take 20-50 days to arrive by boat to the Northern hemisphere, softening and dehydration being the main defects upon arrival. The effect of maturity at harvest (75% blue, 100% blue, and overripe) on cuticular triterpene content ...
Graell i Sarle, Jordi, Lara Ayala, Isabel, Lobos, Gustavo A., Moggia Lucchini, Claudia, Schmeda-Hirschmann, Guillermo, Thomas-Valdés, Samanta   +5 more
core   +2 more sources

Ursolic acid, a natural pentacyclic triterpenoid, inhibits intracellular trafficking of proteins and induces accumulation of intercellular adhesion molecule-1 linked to high-mannose-type glycans in the endoplasmic reticulum

FEBS Open Bio, 2014
Ursolic acid (3β-hydroxy-urs-12-en-28-oic acid) is a natural pentacyclic triterpenoid that is present in many plants, including medicinal herbs, and foods.
Satoshi Mitsuda, Tomonobu Yokomichi, Junpei Yokoigawa, Takao Kataoka   +3 more
doaj   +1 more source