Results 21 to 30 of about 5,145,076 (274)

Ursolic Acid Analogs as Potential Therapeutics for Cancer

Molecules, 2022
Ursolic acid (UA) is a pentacyclic triterpene isolated from a large variety of vegetables, fruits and many traditional medicinal plants. It is a structural isomer of Oleanolic Acid.
S. Panda, M. Thangaraju, B. Lokeshwar
semanticscholar   +1 more source

Ursolic acid reverses liver fibrosis by inhibiting NOX4/NLRP3 inflammasome pathways and bacterial dysbiosis

Gut microbes, 2021
Activation of the NOX4/NLRP3 inflammasome pathway has been associated with fibrosis in other organs. An imbalance in intestinal bacteria is an important driving factor of liver fibrosis through the liver-gut axis.
Y. Nie, Qi Liu, Wang Zhang, Yipeng Wan, Chenkai Huang, Xuan Zhu   +5 more
semanticscholar   +1 more source

Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits

Antioxidants, 2021
Ursolic acid (UA) is a well-studied natural pentacyclic triterpenoid found in herbs, fruit and a number of traditional Chinese medicinal plants. UA has a broad range of biological activities and numerous potential health benefits.
Huynh Nguyen, S. Ullevig, John D. Short, Luxi Wang, Y. Ahn, R. Asmis   +5 more
semanticscholar   +1 more source

Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases

International Journal of Molecular Sciences, 2021
Ursolic acid (UA) is a pentacyclic triterpenoid frequently found in medicinal herbs and plants, having numerous pharmacological effects. UA and its analogs treat multiple diseases, including cancer, diabetic neuropathy, and inflammatory diseases.
Manzar Alam, Sabeeha Ali, Sarfraz Ahmed, A. Elasbali, M. Adnan, A. Islam, M. Hassan, D. Yadav   +7 more
semanticscholar   +1 more source

The Synergistic Reducing Drug Resistance Effect of Cisplatin and Ursolic Acid on Osteosarcoma through a Multistep Mechanism Involving Ferritinophagy

Oxidative Medicine and Cellular Longevity, 2021
Increasing evidence suggests that traditional Chinese medicine strategies are obviously beneficial for cancer treatment, but scientific research on the underlying molecular mechanisms is lacking.
Zhen Tang, Hui Dong, Tianya Li, Ning Wang, Xinghui Wei, Hao Wu, Yichao Liu, Wei Wang, Zheng Guo, Xin Xiao   +9 more
semanticscholar   +1 more source

Ursolic acid, a natural pentacyclic triterpenoid, inhibits intracellular trafficking of proteins and induces accumulation of intercellular adhesion molecule-1 linked to high-mannose-type glycans in the endoplasmic reticulum

FEBS Open Bio, 2014
Ursolic acid (3β-hydroxy-urs-12-en-28-oic acid) is a natural pentacyclic triterpenoid that is present in many plants, including medicinal herbs, and foods.
Satoshi Mitsuda, Tomonobu Yokomichi, Junpei Yokoigawa, Takao Kataoka   +3 more
doaj   +1 more source

Fruit characteristics and cuticle triterpenes as related to postharvest quality of highbush blueberries [PDF]

, 2016
Chilean fresh blueberries take 20-50 days to arrive by boat to the Northern hemisphere, softening and dehydration being the main defects upon arrival. The effect of maturity at harvest (75% blue, 100% blue, and overripe) on cuticular triterpene content ...
Graell i Sarle, Jordi, Lara Ayala, Isabel, Lobos, Gustavo A., Moggia Lucchini, Claudia, Schmeda-Hirschmann, Guillermo, Thomas-Valdés, Samanta   +5 more
core   +2 more sources

Complexation between oleanolic and maslinic acids with native and modified cyclodextrins [PDF]

, 2018
Oleanolic (OA) and maslinic (MA) acids are two natural triterpenoids with a wide range of beneficial effects for human health. However, their low solubility and permeability make their application in the food or industry difficult. The complexation of OA
López Miranda, Santiago
core   +2 more sources

Ursolic Acid Inhibits Na+/K+-ATPase Activity and Prevents TNF-α-Induced Gene Expression by Blocking Amino Acid Transport and Cellular Protein Synthesis

Biomolecules, 2011
Pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, induce the expression of a wide variety of genes, including intercellular adhesion molecule-1 (ICAM-1).
Takao Kataoka, Masayoshi Ando, Shigeru Taketani, Liwei Fu, Yuriko Yamada, Nana Oshima, Tomonobu Yokomichi, Kyoko Morimoto   +7 more
doaj   +1 more source

Antibacterial compounds of the cultivated Robusta coffee: Coffea canephora Pierre ex A. Froehner

Scientific African, 2022
The stems and leaves of robusta coffee, Coffea canephora Pierre ex A. Froehner, one of the traded Coffea species, yielded caffeine (1), lupeol (2), ursolic acid (3), 3β-acetyl oleanolic acid (4), friedelin (5), asperphernamate (6), squalene (7 ...
S.G. Mewaba, E.N. Happi, B.M.N. Nangmou, M.K. Langat, H. Siddique, N. Sadgrove, A.F.W. Kamdem, J.C. Vardamides, E. Mas-Claret, S.M. Isyaka, W. Rotich, B.G.A. Azebaze   +11 more
doaj   +1 more source