Results 61 to 70 of about 876,774 (280)
مدیریت اطلاعات سلامت, 2020 مقدمه: به دلیل توسعه کاربردپذیری سامانههای مدیریت نشریات ادواری دانشگاههای علوم پزشکی کشور که از پرمخاطبترین سامانههای دانشگاهی به شمار میروند و همچنین، عدم وجود مطالعات مرتبط، پژوهش حاضر با هدف تعیین هشت مؤلفه کاربردپذیری سیستمها و مقایسه سامانه ...
Amir Mohamad Mozafari-Vanani +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Technical Development of a Prototype Lower-Limb Therapy Device for Bed-Resting Users
ActuatorsIt is generally recommended that bed-resting patients be mobilised early to promote recovery. The aim of this work was to develop and evaluate the usability of a prototype in-bed lower-limb therapy device that offers various training patterns for the ...
Juan Fang +4 more
doaj +1 more source
Assembling and Rearranging Digital Objects in Physical Space with Tongs, a Gluegun, and a Lightsaber [PDF]
, 2002 We present an interface for the arrangement of objects in three-dimensional space. Physical motions of the user are mapped to interface commands through tangible props.
Schkolne, Steven, Schröder, Peter
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Finger-stylus for non touch-enable systems
Journal of King Saud University: Engineering Sciences, 2017 Since computer was invented, people are using many devices to interact with computer. Initially there were keyboard, mouse etc. but with advancement of technology, new ways are being discovered that are quite common and natural to the humans like stylus ...
Ankit Chaudhary
doaj +1 more source
Software systems for modeling articulated figures [PDF]
Research in computer animation and simulation of human task performance requires sophisticated geometric modeling and user interface tools. The software for a research environment should present the programmer with a powerful but flexible substrate of ...
Phillips, Cary B.
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source