Results 61 to 70 of about 876,550 (328)
The Technical Development of a Prototype Lower-Limb Therapy Device for Bed-Resting Users
ActuatorsIt is generally recommended that bed-resting patients be mobilised early to promote recovery. The aim of this work was to develop and evaluate the usability of a prototype in-bed lower-limb therapy device that offers various training patterns for the ...
Juan Fang +4 more
doaj +1 more source
Intelligent Human Machine Interface Design for Advanced Product Life Cycle Management Systems
, 2009 Designing and implementing an intelligent and user friendly human machine interface for any kind of software or hardware oriented application is always be a challenging task for the designers and developers because it is very difficult to understand the ...
Ahmed, Zeeshan
core +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
مدیریت اطلاعات سلامت, 2020 مقدمه: به دلیل توسعه کاربردپذیری سامانههای مدیریت نشریات ادواری دانشگاههای علوم پزشکی کشور که از پرمخاطبترین سامانههای دانشگاهی به شمار میروند و همچنین، عدم وجود مطالعات مرتبط، پژوهش حاضر با هدف تعیین هشت مؤلفه کاربردپذیری سیستمها و مقایسه سامانه ...
Amir Mohamad Mozafari-Vanani +3 more
doaj +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Finger-stylus for non touch-enable systems
Journal of King Saud University: Engineering Sciences, 2017 Since computer was invented, people are using many devices to interact with computer. Initially there were keyboard, mouse etc. but with advancement of technology, new ways are being discovered that are quite common and natural to the humans like stylus ...
Ankit Chaudhary
doaj +1 more source
Feasibility study of an Integrated Program for Aerospace vehicle Design (IPAD). Volume 3: Support of the design process [PDF]
The user requirements for computer support of the IPAD design process are identified.
Bateman, R. E. +3 more
core +1 more source
Supporting shape reinterpretation with eye tracking [PDF]
, 2011 It has been argued that reinterpretation is an essential process in design generation and idea exploration. However, computational design tools, such as computer-aided design systems, offer poor support for shape reinterpretation, and as such are not ...
Garner, Steven +4 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source