Ubiquitin-specific proteases as key regulators in the malignant progression and therapy resistance of colorectal cancer: current insights and future perspectives [PDF]
Discover OncologyAs a member of the DUBs (deubiquitinating enzymes) family, USPs (ubiquitin-specific peptidases) play a crucial regulatory role in the occurrence and progression of various malignancies.
Junyan Li +9 more
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Ultra-Short Peptide Hydrogels as 3D Bioprinting Materials [PDF]
GelsUltra-short peptides (USPs; ≤7–8 amino acids) emerge as minimal self-assembling building blocks for hydrogel-based biomaterials. Their intrinsic biocompatibility, straightforward synthesis, and ease of tunability make them particularly attractive ...
Davina In +3 more
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Molecular CancerDrug resistance represents a significant obstacle in cancer treatment, underscoring the need for the discovery of novel therapeutic targets. Ubiquitin-specific proteases (USPs), a subclass of deubiquitinating enzymes, play a pivotal role in protein ...
Zhuo Xi, Chen Zhiguang, Xue Jinqi
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Ubiquitin-specific peptidases in lymphoma: a path to novel therapeutics [PDF]
Frontiers in PharmacologyBackgroundUbiquitin-specific peptidases (USPs), also known as deubiquitinating enzymes (DUBs), play a crucial role in maintaining cellular homeostasis by selectively removing ubiquitin molecules from targeted proteins.
Maryam Samareh Salavatipour +12 more
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Journal of Experimental and Clinical Cancer Research, 2023 Tumors have evolved in various mechanisms to evade the immune system, hindering the antitumor immune response and facilitating tumor progression. Immunotherapy has become a potential treatment strategy specific to different cancer types by utilizing ...
Ce Ji, Fei Xing, Xue Jinqi
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The Evolution and expression analysis of USP gene family in Solanum [PDF]
Frontiers in Plant ScienceAs natural environments degrade and extreme weather events become more frequent, humanity increasingly faces the challenge of producing crops under various complex and adverse conditions. Improving crop adaptability has become crucial.
Ruiqiang Xu +10 more
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Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation [PDF]
World Journal of Surgical OncologyBreast cancer is a prevalent malignancy worldwide, and its treatment has increasingly shifted towards precision medicine, with immunotherapy emerging as a key therapeutic strategy.
Huiyuan Yang +7 more
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Ubiquitin-specific protease: an emerging key player in cardiomyopathy [PDF]
Cell Communication and SignalingProtein quality control (PQC) plays a vital role in maintaining normal heart function, as cardiomyocytes are relatively sensitive to misfolded or damaged proteins, which tend to accumulate under pathological conditions.
Danlei Li, Qilin Ma
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Pharmacological ResearchCancer represents a significant global health threat, with the World Health Organization reporting millions of new cases annually. Dysregulation in cellular homestasis leads to the aggressive and heterogeneous nature of cancers.
Zhuo Xi
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The exploration of high production of tiancimycins in Streptomyces sp. CB03234-S revealed potential influences of universal stress proteins on secondary metabolisms of streptomycetes [PDF]
Microbial Cell FactoriesBackground Universal stress proteins (USPs) are prevalent in various bacteria to cope with different adverse stresses, while their possible effects on secondary metabolisms of hosts are unclear.
Huiming Liu +6 more
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