Results 121 to 130 of about 491,422 (252)
Covalent Inhibition of VCP/p97 This frontispiece highlights the hexameric VCP/p97 AAA+ ATPase complex (blue), a central regulator of protein homeostasis. Small‐molecule inhibition of VCP has emerged as a promising therapeutic strategy. UTE‐156 (green) represents a covalent inhibitor targeting Cys522 within the D2 ATPase domain.
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
Mapa de Investigaciones Científicas sobre Economía Circular con Origen en Ecuador
La recuperación de los desechos sólidos para su conversión en recursos para el futuro tiene un papel importante para lograr la sostenibilidad ambiental y desarrollar modelos de economía circular.
Renato Patricio Erazo-Rivera +3 more
doaj +1 more source
Barnehagelærarutdanning Høgskulen på Vestlandet, avdeling Sogndal Fakultet for lærarutdanning, kultur og idrett 07.01 ...
Kvamme, Eline, Hukset, Stine
openaire +1 more source
ABSTRACT Objective Anorexia nervosa (AN) is a severe eating disorder associated with extreme weight loss, hyperactivity, and amenorrhea. Neuroimaging studies revealed brain atrophy and disruption of white matter integrity in the corpus callosum (CC) of patients with AN. However, the underlying pathophysiological mechanisms remain unclear.
Stephan Lang +9 more
wiley +1 more source
Linking hydromorphological diversity to biodiversity and functioning in running waters
Abstract Environmental heterogeneity is a key driver of biodiversity and ecosystem functioning, yet linking physical habitat variability to ecological attributes remains challenging in aquatic ecosystems. Here, we present a unified framework that applies variance partitioning to hydromorphological characteristics—specifically flow velocity and depth—to
Christine Anlanger +6 more
wiley +1 more source
3D inversion recovery ultrashort echo time MRI can detect demyelination in cuprizone-treated mice
PurposeTo test the ability of inversion-recovery ultrashort echo time (IR-UTE) MRI to directly detect demyelination in mice using a standard cuprizone mouse model.MethodsNon-aqueous myelin protons have ultrashort T2s and are “invisible” with conventional
Adam C. Searleman +11 more
doaj +1 more source
I denne rapporten resonnerer vi omkring et eventuelt forbud mot synlig framvisning av tobakksvarer i butikk. Vi drøftet hvorvidt et slikt tiltak kan tenkes å virke etter hensikten, dvs. å redusere andelen røykere, spesielt blant ungdom. Vi spør også om de samfunnsmessige gevinstene ved et slikt tiltak står i et rimelig forhold til kostnadene for ...
Jacobsen, Eivind, Lavik, Randi
openaire +1 more source
ABSTRACT Purpose To design 3D radial spiral phyllotaxis trajectories aimed at removing phase inconsistencies, improving image quality, and enhancing parametric mapping accuracy by acquiring nearly opposing spokes starting from both hemispheres in 3D radial k‐space. Methods Two 3D radial trajectories, pole‐to‐pole and continuous spiral phyllotaxis, were
Eva S. Peper +12 more
wiley +1 more source
Capacitación transformadora: evidencia del efecto formativo en emprendedores ecuatorianos
El presente trabajo analiza el impacto de dos acciones formativas —Gestión Financiera para MYPES e Innovación y Diseño de Modelos de Negocio— dirigidas a emprendedores de la provincia de Pichincha, Ecuador.
José Luis Basantes Garcés +2 more
doaj +1 more source

