Results 131 to 140 of about 87,906 (309)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Local sustainable development and well-being/quality of life. An application of the capability approach at regional level [PDF]

This paper has a twofold aim: the former is to focus on the concept of well-being/quality of life and its relationships with local sustainable development and the latter is to apply the capability approach at regional level.
Alba Distaso
core  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Income Taxes, Property Values, and Migration [PDF]

We consider taxation by a Leviathan government and by a utilitarian government in the presence of heterogeneous locations within a country, when migration from one country to another is and is not possible.
Amihai Glazer, Panu Poutvaara, Vesa Kanniainen   +2 more
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The Potential of the Science-Religion Confluence for Affecting Policy and Administration [PDF]

, 2012
The author's understanding of the full scope of God's covenant after the Flood, together with the scientific insights of systems theory, guided him to implement a new approach in administering national restoration and protection policy.
Babbitt, Bruce
core   +1 more source

An Examination of Impulsive Buying, Utilitarian Consumption, Hedonic Consumption, and Conspicuous Consumption Habits in Consumers' Mobile Shopping Behavior: The Case of Temu

Iğdır Üniversitesi Sosyal Bilimler Dergisi
This study aims to examine the impact of mobile shopping platforms on consumer behavior through a case study of Temu. Specifically, it investigates how impulsive buying behavior is associated with utilitarian, hedonic, and conspicuous consumption tendencies.
openaire   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Development and Validation of the Scale for Analysing the Consumption Behaviours of E-Sports Players Using a Mixed-Methods Approach

SAGE Open
This paper aims to develop the E-Sports Consumption Behaviour Assessment Scale (E-CBAs) to assess consumption trends among e-sports consumers, addressing the economic and social dimensions of the digital gaming industry.
Oguzhan Gul, Zuhal Yurtsizoglu
doaj   +1 more source