Results 81 to 90 of about 87,906 (309)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
THE INFLUENCE OF FASHION BLOGS IN THE FEMALE CONSUMER PURCHASE DECISION PROCESS
Contextus, 2018 This article aims to analyze how female consumers are influenced by contents published in fashion blogs. To do so, it examines two blogs—Entre Topetes e Vinis, oriented towards the plus size public, and Garotas Estúpidas, of regular fashion—, by ...
Carla Cristine Vianna Nogueira +2 more
doaj +1 more source
An Environmental-Economic Measure of Sustainable Development [PDF]
A central issue in the study of sustainable development is the interplay of growth and sacrifice in a dynamic economy. This paper investigates the relationship among current consumption, growth, and sustained consumption in two canonical, stylized ...
Robert D. Cairns, Vincent Martinet
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
The role of collaborative consumption in the servitization of digital service platforms
Management şi MarketingThis research aims to understand the digital service platform usage intention and behavior from the perspectives of technology adoption and collaborative consumption.
Guleren Can +2 more
doaj +1 more source
Take it or Leave it: Take-up, Optimal Transfer Programs, and Monitoring [PDF]
This paper studies the optimal income redistribution and optimal monitoring when disability benefits are intended for disabled people but when some able agents with high distaste for work mimic them (type II errors).
Laurence Jacquet
core
Co-creative pricing (CCP) : a conceptual development of consumers’ participation in pricing practicing in services [PDF]
, 2011 Keskustelu yhteisestä arvonluonnista on saavuttanut yhä laajempaa huomiota niin nykypäivän tieteellisteoreettisessa markkinointikirjallisuudessa kuin käytännössä. Suosiosta huolimatta keskustelusta on jäänyt miltei tyystin huomioimatta arvokäsitteen eräs
Estabrook, Daniel
core
Well-Being, Inequality and Time: The Time-Slice Problem and its Policy Implications [PDF]
, 2007 Should equality be viewed from a lifetime or sublifetime perspective? In measuring the inequality of income, for example, should we measure the inequality of lifetime income or of annual income? In characterizing a tax as progressive or regressive,
Adler, Matthew D.
core +4 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source