Results 91 to 100 of about 1,355,209 (298)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Relativity, rank and the utility of income [PDF]

, 2008
This is the accepted version of the following article: Rablen, M. D. (2008), Relativity, Rank and the Utility of Income. The Economic Journal, 118: 801–821, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/j.1468-0297 ...
Argyle, Becker, Benartzi, Blanchflower, Boskin, Bowman, Brickman, Brickman, Brickman, Brown, Campbell, Cantril, Clark, Clark, Clark, Clark, Cole, Cole, Cole, Constantinides, Dhillon, Di Tella, Diener, Diener, Duesenberry, Easterlin, Easterlin, Easterlin, Easterlin, Emmons, Frank, Frank, Frank, Frank, Frederick, Frey, Friedman, Friedman, Gibrat, Gilboa, Gregory, Haubensak, Haubensak, Hsee, Kahneman, Kahneman, Kahneman, Kahneman, Kapteyn, Kapteyn, Kenny, Kilpatrick, Knetsch, Kornienko, Köbberling, Kőszegi, Landon‐Lane, Layard, Leland, Lipset, Loewenstein, Luttmer, March, Marmot, Marmot, Marshall, Matthew D. Rablen, McBride, Murray, Myers, Oswald, Parducci, Parducci, Parducci, Parducci, Rainwater, Rainwater, Robson, Runciman, Samuelson, Schmidt, Seidl, Shapira, Stutzer, Stutzer, Sullivan, Thompson, Tommasi, Tversky, Tversky, Van de Stadt, Van Herwaarden, Van Praag, Van Praag, Van Praag, Van Praag, Van Praag, Van Praag, Van Praag, Veblen   +99 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Measuring Balance Abilities of Transtibial Amputees Using Multiattribute Utility Theory. [PDF]

Biomed Res Int, 2021
Zhang X, Liu Z, Qiu G.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Range dependent expected utility theory based model for NIMBY conflicts in China: An evolutionary game analysis. [PDF]

PLoS One, 2022
Zhao H, Wang W, Zhang M.
europepmc   +1 more source

The Illusion of Irrationality [PDF]

This short paper shows that the Allais Paradox and the Common Ratio Effect regarded as classic examples of the violation of the Expected Utility Theory Axioms – may be easily explained by assuming that changes in wealth (i.e.
Kontek, Krzysztof
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Nonhuman Primates Satisfy Utility Maximization in Compliance with the Continuity Axiom of Expected Utility Theory. [PDF]

J Neurosci, 2021
Ferrari-Toniolo S, Bujold PM, Grabenhorst F, Báez-Mendoza R, Schultz W.   +4 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source