Results 31 to 40 of about 356,274 (192)

Gnaq and Gna11 in the Endothelin signaling pathway and melanoma

Frontiers in Genetics, 2016
In this article, we first briefly outline the function of G protein coupled receptors in cancer, and then specifically examine the roles of the seven transmembrane G protein coupled Endothelin B receptor (Ednrb) and the G proteins, GNAQ and GNA11, in ...
Oscar eUrtatiz, Catherine D Van Raamsdonk   +1 more
doaj   +1 more source

Amelanotic ocular melanoma with lung metastasis in a domestic rabbit (Oryctolagus cuniculus) [PDF]

Ciência Rural
: Uterine adenocarcinoma and lymphoma are among the most diagnosed neoplasms in rabbits. Melanomas have also been reported in rabbits; however, they occur less frequently.
Ronaldo José Piccoli, Vinicius Dahm, Karim Cristhine Pase Montagnini, Arthur Colombari Cheng, Stacy Wu, Amália Ferronato, Crisan Smaniotto, Anderson Luiz de Carvalho, Aline de Marco Viott   +8 more
doaj   +1 more source

Frequent somatic mutations of GNAQ in uveal melanoma and blue nevi

Nature, 2008
BRAF and NRAS are common targets for somatic mutations in benign and malignant neoplasms that arise from melanocytes situated in epithelial structures, and lead to constitutive activation of the mitogen-activated protein (MAP) kinase pathway.
Catherine D. Van Raamsdonk, V. Bezrookove, G. Green, J. Bauer, Lona Gaugler, J. O'Brien, E. M. Simpson, G. Barsh, Boris C. Bastian   +8 more
semanticscholar   +1 more source

BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs

Journal of Translational Medicine, 2012
Background BRCA1–associated protein 1 (BAP1) is a tumor suppressor gene located on chromosome 3p21. Germline BAP1 mutations have been recently associated with an increased risk of malignant mesothelioma, atypical melanocytic tumors and other neoplasms ...
Carbone Michele, Ferris Laura, Baumann Francine, Napolitano Andrea, Lum Christopher A, Flores Erin G, Gaudino Giovanni, Powers Amy, Bryant-Greenwood Peter, Krausz Thomas, Hyjek Elizabeth, Tate Rachael, Friedberg Joseph, Weigel Tracey, Pass Harvey I, Yang Haining   +15 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Uveitis Masquerade Syndrome

Journal of Ophthalmology
The ‘uveitis masquerade syndrome’ is a large group of neoplastic and non-neoplastic conditions that mimic and are initially misdiagnosed as uveitis. These eye diseases account for approximately 5% of all presentations at tertiary referral uveitis clinics.
M. K. Shields, L. B. Ferreira, A. L. Farrall, J. R. Smith   +3 more
doaj   +1 more source

Vitamin D receptors (VDR), hydroxylases CYP27B1 and CYP24A1 and retinoid-related orphan receptors (ROR) level in human uveal tract and ocular melanoma with different melanization levels

Scientific Reports, 2019
In recent years, a significant number of studies have investigated the preventive role of vitamin D in a number of different neoplasms. In this study, we analyze various components of the vitamin D signaling pathways in the human uveal tract and uveal ...
A. Markiewicz, A. Brożyna, E. Podgorska, M. Elas, K. Urbanska, A. Jetten, A. Slominski, W. Jóźwicki, J. Orłowska-Heitzman, G. Dyduch, B. Romanowska-Dixon   +10 more
semanticscholar   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Evidências obtidas de um caso de melanoma de íris recidivado Evidences from a case of recurrent iris melanoma

Revista Brasileira de Oftalmologia, 2009
O artigo apresenta uma análise histológica de um caso de melanoma recidivado de íris após sete meses da iridociclectomia, em uma paciente de 45 anos.
Juliana de Lucena Martins Ferreira, Márjorie Sabino Façanha Barreto Rolim, Cícero Narciso Moreira Leite, Fernando Queiroz Monte, Marineuza Rocha Memória   +4 more
doaj   +1 more source