Results 41 to 50 of about 87,820 (142)

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Uveal melanoma: Ocular and systemic disease [PDF]

, 2012
Although rare, uveal melanoma is the most common intraocular tumor in adults. Most cases arise from the choroidal layer of the uvea, displaying a discoid, collar-button, or mushroom shaped growth.
Bakalian, Silvin, Fernandes, Bruno F., Silvin Bakalian, Burnier, Miguel N., Miyamoto, Cristina, Bruno F. Fernandes, Balazsi, Matthew, Cristina Miyamoto, Matthew Balazsi, Miguel N. Burnier   +9 more
core   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

A Ferrous‐Supply‐Regenerating Lipid Nanoparticle Integrating RNAi Induces Ferroptosis for Cancer Therapy

Small, EarlyView.
ABSTRACT Targeting iron‐dependent ferroptosis with siRNA has emerged as a promising strategy for cancer treatment. The concept of ferrous‐supply regeneration, inspired by electro‐Fenton technology, has also gained interest as a non‐apoptotic approach to induce ferroptosis.
Dun Hu, Yun‐Hua Xu, Dan Peng, Qi Tan, Jun‐Lin Jiang, Sheng‐Dan Nie, Shan Wang   +6 more
wiley   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Three years of ocular proton therapy in the Netherlands, clinical results

Acta Ophthalmologica, EarlyView.
Abstract Purpose Uveal melanoma (UM) is a rare cancer with rising number of diagnosis (143 diagnoses in 1990 to 226 in 2023) in the Netherlands. Most patients are treated locally with Ruthenium‐106 brachytherapy (±102/year). Patients were referred for proton therapy (PT) to Switzerland in the past, but PT is available in the Netherlands from January ...
C. Rasch, M. Marinkovic, L. Pors, E. Kilic, N. Naus, S. Yavuzyigitoglu, P. A. Bakker, C. van Rij, J. W. Beenakker, J. Bleeker, A. Schalenbourg, A. Pica, J. Hrbacek, N. Horeweg, K. Vu   +14 more
wiley   +1 more source

SMARCB1 (INI1)-deficient malignant melanocytic neoplasm with histologically confirmed vertebral metastases in a young adult: a case report

Frontiers in Oncology
BackgroundSMARCB1 (INI1)-deficient tumors are rare aggressive neoplasms characterized by biallelic inactivation of the SMARCB1 gene and loss of nuclear INI1 protein expression.
Ibrahim Al-Hassana, Lethongsavarn Vincent, Setcheou Alihonou, Sieleche Christian, Mahamadou Ango Souleymane, Rabhi Mohammed, Do Laurent   +6 more
doaj   +1 more source

Molecular heterogeneity and prognostic biomarkers in primary meningeal melanocytic tumors

Brain Pathology, EarlyView.
Integrated molecular profiling reveals biological heterogeneity among primary meningeal melanocytic tumors, identifying intermediate‐grade PMMT subgroups with distinct recurrence risk. Molecular alterations including SF3B1 mutations and chromosome 8q gains support prognostic stratification, while PRKAR1A alterations and chromosome 17/21q losses aid ...
Rosina Paterra, Monica Patanè, Anna Stroppa, Gianluca Marucci, Serena Ammendola, Sofia Asioli, Valeria Barresi   +6 more
wiley   +1 more source

Blue Nevi and Melanoma Arising in Blue Nevus: A Comparative Histopathological Case Series

Reports
Background and Clinical Significance: Blue nevi are a dubious pigmented lesion. While somewhat common throughout the population, they are significantly less common than other melanocytic neoplasms, and both their morphology and development bring them ...
Hristo Popov, Pavel Pavlov, George S. Stoyanov   +2 more
doaj   +1 more source

Uncommon Presentations of Pancreatic Neoplasms, Rare Neoplasms, and Peripancreatic Masses

, 2022
Pancreatic masses with atypical radiological appearance are frequently encountered. Atypical presentation of common pancreatic tumor is also possible.
Antonia Olivieri, Roberto Calbi, Paola Capelli, Angela Calabrese, Paolo Tinazzi Martini, Nicolò Cardobi, Mirko D’Onofrio, Riccardo De Robertis, Luca Geraci   +8 more
core   +1 more source