Results 31 to 40 of about 360,760 (179)

Gnaq and Gna11 in the Endothelin signaling pathway and melanoma

Frontiers in Genetics, 2016
In this article, we first briefly outline the function of G protein coupled receptors in cancer, and then specifically examine the roles of the seven transmembrane G protein coupled Endothelin B receptor (Ednrb) and the G proteins, GNAQ and GNA11, in ...
Oscar eUrtatiz, Catherine D Van Raamsdonk   +1 more
doaj   +1 more source

Fatty acid-binding protein 5 predicts poor prognosis in patients with uveal melanoma

Oncology Letters, 2020
Fatty acid-binding protein 5 (FABP5), which participates in mediating the biological properties of tumor cells, has been recognized in several neoplasms.
Yue Xu, Wenhao Xu, xiaolong yang, Hai-Liang Zhang, Xiaofeng Zhang   +4 more
semanticscholar   +1 more source

Amelanotic ocular melanoma with lung metastasis in a domestic rabbit (Oryctolagus cuniculus) [PDF]

Ciência Rural
: Uterine adenocarcinoma and lymphoma are among the most diagnosed neoplasms in rabbits. Melanomas have also been reported in rabbits; however, they occur less frequently.
Ronaldo José Piccoli, Vinicius Dahm, Karim Cristhine Pase Montagnini, Arthur Colombari Cheng, Stacy Wu, Amália Ferronato, Crisan Smaniotto, Anderson Luiz de Carvalho, Aline de Marco Viott   +8 more
doaj   +1 more source

Mutations in GNA11 in Uveal Melanoma

New England Journal of Medicine, 2010
BACKGROUND Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in 40% of uveal melanomas.
C. V. Raamsdonk, K. Griewank, M. B. Crosby, M. Garrido, Swapna S. Vemula, T. Wiesner, A. Obenauf, W. Wackernagel, G. Green, N. Bouvier, M. Sozen, Gail Baimukanova, R. Roy, A. Heguy, Igor Dolgalev, R. Khanin, K. Busam, M. Speicher, J. O'Brien, B. Bastian   +19 more
semanticscholar   +1 more source

BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs

Journal of Translational Medicine, 2012
Background BRCA1–associated protein 1 (BAP1) is a tumor suppressor gene located on chromosome 3p21. Germline BAP1 mutations have been recently associated with an increased risk of malignant mesothelioma, atypical melanocytic tumors and other neoplasms ...
Carbone Michele, Ferris Laura, Baumann Francine, Napolitano Andrea, Lum Christopher A, Flores Erin G, Gaudino Giovanni, Powers Amy, Bryant-Greenwood Peter, Krausz Thomas, Hyjek Elizabeth, Tate Rachael, Friedberg Joseph, Weigel Tracey, Pass Harvey I, Yang Haining   +15 more
doaj   +1 more source

Frequent somatic mutations of GNAQ in uveal melanoma and blue nevi

Nature, 2008
BRAF and NRAS are common targets for somatic mutations in benign and malignant neoplasms that arise from melanocytes situated in epithelial structures, and lead to constitutive activation of the mitogen-activated protein (MAP) kinase pathway.
Catherine D. Van Raamsdonk, V. Bezrookove, G. Green, J. Bauer, Lona Gaugler, J. O'Brien, E. M. Simpson, G. Barsh, Boris C. Bastian   +8 more
semanticscholar   +1 more source

Incidence and survival of uveal melanoma occurring as single cancer versus its occurrence as a first or second primary neoplasm

Annals of Oncology, 2019
Abstract Background Uveal Melanoma (UVM) is the most common ocular malignancy. Many mutations were identified in affected patients defining genetic predisposition syndromes. Previous studies discussed separately the incidence of single or second primary ocular melanomas.
A.S. Alfaar, A.M. Saad, S. Elzouki
openaire   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Uveitis Masquerade Syndrome

Ukrainian Journal of Ophthalmology
The ‘uveitis masquerade syndrome’ is a large group of neoplastic and non-neoplastic conditions that mimic and are initially misdiagnosed as uveitis.
M. K. Shields, L. B. Ferreira, A. L. Farrall, J. R. Smith   +3 more
doaj   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source