Frontiers in Plant Science, 2022 V-ATPase is the dominant proton pump in plant cells. It contributes to cytosolic pH homeostasis and energizes transport processes across endomembranes of the secretory pathway.
Thorsten Seidel
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The role of individual domains and the significance of shedding of ATP6AP2/(pro)renin receptor in vacuolar H(+)-ATPase biogenesis. [PDF]
PLoS ONE, 2013 The ATPase 6 accessory protein 2 (ATP6AP2)/(pro)renin receptor (PRR) is essential for the biogenesis of active vacuolar H(+)-ATPase (V-ATPase). Genetic deletion of ATP6AP2/PRR causes V-ATPase dysfunction and compromises vesicular acidification.
Kenichiro Kinouchi +12 more
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Defining steps in RAVE-catalyzed V-ATPase assembly using purified RAVE and V-ATPase subcomplexes [PDF]
Journal of Biological Chemistry, 2021 The vacuolar H+-ATPase (V-ATPase) is a highly conserved proton pump responsible for the acidification of intracellular organelles in virtually all eukaryotic cells. V-ATPases are regulated by the rapid and reversible disassembly of the peripheral V1 domain from the integral membrane Vo domain, accompanied by release of the V1 C subunit from both ...
Michael C. Jaskolka +4 more
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Probing subunit-subunit interactions in the yeast vacuolar ATPase by peptide arrays. [PDF]
PLoS ONE, 2012 BACKGROUND:Vacuolar (H(+))-ATPase (V-ATPase; V(1)V(o)-ATPase) is a large multisubunit enzyme complex found in the endomembrane system of all eukaryotic cells where its proton pumping action serves to acidify subcellular organelles. In the plasma membrane
Lee S Parsons, Stephan Wilkens
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Molecular basis of mEAK7-mediated human V-ATPase regulation
Nature Communications, 2022 Structural basis of V-ATPase regulation by endogenous proteins is unclear. Here, the authors find mEAK7 as an endogenous V-ATPase modulator and determine its structure with V-ATPase, suggesting the potential role of mEAK7 in V-ATPase regulation.
Rong Wang +3 more
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Enhanced expression of vacuolar H+-ATPase subunit E in the roots is associated with the adaptation of Broussonetia papyrifera to salt stress. [PDF]
PLoS ONE, 2012 Vacuolar H(+)-ATPase (V-H(+)-ATPase) may play a pivotal role in maintenance of ion homeostasis inside plant cells. In the present study, the expression of V-H(+)-ATPase genes was analyzed in the roots and leaves of a woody plant, Broussonetia papyrifera,
Min Zhang +3 more
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Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei [PDF]
, 2020 BACKGROUND Vacuolar H-ATPase (V-ATPase) is a highly conserved protein complex which hydrolyzes ATP and pumps protons to acidify vacuolar vesicles.
Hide, G +4 more
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SNARE, V-ATPase et neurotransmission [PDF]
médecine/sciences, 2011 > La communication entre neurones repose principalement sur les synapses chimiques et par consequent sur la liberation de neurotransmetteurs. Au niveau des terminaisons nerveuses, des vesicules synaptiques remplies de neurotransmetteurs s’arriment a la membrane plasmique et subissent des etapes de maturation qui les rendent competentes pour la fusion ...
El Far, Oussama, Seagar, Michael
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The V-ATPase in insect epithelia [PDF]
Journal of Experimental Biology, 2017 ![Figure][1] Mike O'Donnell discusses the impact of two classic papers, published by Helmut Wieczorek in Journal of Biological Chemistry in 1989 and 1991, which report the discovery of the the insect midgut V-ATPase.
Mike O'Donnell
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Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium. [PDF]
PLoS ONE, 2010 Lung surfactant reduces surface tension and maintains the stability of alveoli. How surfactant is released from alveolar epithelial type II cells is not fully understood. Vacuolar ATPase (V-ATPase) is the enzyme responsible for pumping H(+) into lamellar
Narendranath Reddy Chintagari +6 more
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