Results 21 to 30 of about 156,233 (327)
V-ATPase engagement in autophagic processes [PDF]
Autophagy, 2011 The proton pumping activity of V-ATPase is responsible for acidification of the lysosome/vacuole. The low lumenal pH of this organelle stimulates the activity of a battery of resident hydrolases responsible for the degradation of various nonselective and selective cargos delivered by autophagic processes.
Dalibor, Mijaljica +2 more
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Development of RNAi methods for Peregrinus maidis, the corn planthopper. [PDF]
PLoS ONE, 2013 The corn planthopper, Peregrinus maidis, is a major pest of agronomically-important crops. Peregrinus maidis has a large geographical distribution and transmits Maize mosaic rhabdovirus (MMV) and Maize stripe tenuivirus (MSpV).
Jianxiu Yao +4 more
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Duelling functions of the V‐ATPase [PDF]
The EMBO Journal, 2011 The V‐ATPase, the major cellular proton pump, is comprised of the peripheral sector V1 catalysing ATP hydrolysis and the membrane integral sector V0 translocating protons. Ten years ago, Andreas Mayer9s group made the surprising observation that proteolipids of the V0 transmembrane sector are implicated in membrane fusion, but deeper analysis proved to
Scott Cameron C +2 more
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The evolutionary conserved TLDc domain defines a new class of (H+)V-ATPase interacting proteins
Scientific Reports, 2021 We recently found that nuclear receptor coactivator 7 (Ncoa7) and Oxr1 interact with the proton-pumping V-ATPase. Ncoa7 and Oxr1 belong to a group of proteins playing a role in the oxidative stress response, that contain the conserved “TLDc” domain. Here
A. F. Eaton, D. Brown, M. Merkulova
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Regulation of vacuolar H+-ATPase activity by the Cdc42 effector Ste20 in Saccharomyces cerevisiae [PDF]
, 2012 In the budding yeast Saccharomyces cerevisiae, the Cdc42 effector Ste20 plays a crucial role in the regulation of filamentous growth, a response to nutrient limitation.
Höfken, T, Kane, PM, Li, SC, Lin, M
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Reciprocal Regulation of V-ATPase and Glycolytic Pathway Elements in Health and Disease
Frontiers in Physiology, 2019 The ability of cells to adapt to fluctuations in glucose availability is crucial for their survival and involves the vacuolar proton-translocating ATPase (V-ATPase), a proton pump found in all eukaryotes.
Summer R. Hayek +2 more
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Translational Neurodegeneration, 2020 Background Lysosomes digest extracellular material from the endocytic pathway and intracellular material from the autophagic pathway. This process is performed by the resident hydrolytic enzymes activated by the highly acidic pH within the lysosomal ...
Qiaoyun Song +3 more
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Wheat V-H+-ATPase subunit genes significantly affect salt tolerance in Arabidopsis thaliana. [PDF]
PLoS ONE, 2014 Genes for V-H(+)-ATPase subunits were identified and cloned from the salt-tolerant wheat mutant RH8706-49. Sequences of these genes are highly conserved in plants.
Xiaoliang He +3 more
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Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. [PDF]
, 2019 Autophagy is a lysosomal degradation pathway that eliminates aggregated proteins and damaged organelles to maintain cellular homeostasis. A major route for activating autophagy involves inhibition of the mTORC1 kinase, but current mTORC1-targeting ...
Berdan, Charles A +7 more
core +1 more source
Regulation of V-ATPase Assembly in Nutrient Sensing and Function of V-ATPases in Breast Cancer Metastasis [PDF]
Frontiers in Physiology, 2018 V-ATPases are proton pumps that function to acidify intracellular compartments in all eukaryotic cells, and to transport protons across the plasma membrane of certain specialized cells. V-ATPases function in many normal and disease processes, including membrane traffic, protein degradation, pathogen entry, and cancer cell invasion.
Michael P. Collins, Michael Forgac
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