Results 41 to 50 of about 156,233 (327)

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids [PDF]

, 2016
The mechanistic Target of Rapamycin complex 1 (mTORC1) senses intracellular amino acid levels through an intricate machinery, which includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase).
Appelqvist, Bar-Peled, Bar-Peled, Bar-Peled, Beck, Dibble, Düvel, Fingar, Forgac, Guertin, Hanada, Harrington, Hinton, Hirose, Howell, Hoxhaj, Hsu, Jacinto, Kim, Klausner, Manning, Menon, Morales-Johansson, Nada, Nishi, Pearce, Sancak, Sancak, Sancak, Sarbassov, Sarbassov, Settembre, Shah, Shiota, Showkat, Stefansson, Stefansson, Wengrod, Wullschleger, Yu, Zoncu, Ögmundsdóttir   +41 more
core   +3 more sources

The curious case of vacuolar ATPase: regulation of signaling pathways

Molecular Cancer, 2018
The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the intracellular and extracellular pH of cells. The structure of V-ATPase has been highly conserved among all eukaryotic cells and is involved in diverse functions across ...
Sahithi Pamarthy, Arpita Kulshrestha, Gajendra K. Katara, Kenneth D. Beaman   +3 more
doaj   +1 more source

Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis

Molecular Metabolism, 2021
Objective: The diabetic heart is characterized by extensive lipid accumulation which often leads to cardiac contractile dysfunction. The underlying mechanism involves a pivotal role for vacuolar-type H+-ATPase (v-ATPase, functioning as endosomal ...
Shujin Wang, Francesco Schianchi, Dietbert Neumann, Li-Yen Wong, Aomin Sun, Frans A. van Nieuwenhoven, Maurice P. Zeegers, Agnieszka Strzelecka, Umare Col, Jan F.C. Glatz, Miranda Nabben, Joost J.F.P. Luiken   +11 more
doaj   +1 more source

Rapid purification of human lysosomal membranes, characterisation of the detergent resistent microdomains, purification and reconstitution of the vacuolar proton pump (V-ATPase) [PDF]

, 2006
The lysosomal membrane is a dynamic environment where specific interactions among proteins and between proteins and lipids occur. These interactions are necessary for the proper functioning of the lysosomal apparatus that allows the passage of molecules ...
Chandramohanadas, Rajesh, Hasilik, Andrej (Prof. Dr.)   +1 more
core   +1 more source

V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis

Theranostics, 2018
Vacuolar ATPases (V-ATPases) play a critical role in regulating extracellular acidification of osteoclasts and bone resorption. The deficiencies of subunit a3 and d2 of V-ATPases result in increased bone density in humans and mice. One of the traditional drug design strategies in treating osteoporosis is the use of subunit a3 inhibitor. Recent findings
Duan, Xiaohong, Yang, Shaoqing, Zhang, Lei, Yang, Tielin   +3 more
openaire   +2 more sources

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase [PDF]

, 2011
The mTOR complex 1 (mTORC1) protein kinase is a master growth regulator that is stimulated by amino acids. Amino acids activate the Rag guanosine triphosphatases (GTPases), which promote the translocation of mTORC1 to the lysosomal surface, the site of ...
Bar-Peled, Liron, Efeyan, Alejo, Sabatini, David M., Sancak, Yasemin, Wang, Shuyu, Ph. D. Massachusetts Institute of Technology, Zoncu, Roberto   +5 more
core   +1 more source

Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2016
V-ATPases are ATP-driven proton pumps that function within both intracellular compartments and the plasma membrane in a wide array of normal physiological and pathophysiological processes. V-ATPases are composed of a peripheral V(1) domain that hydrolyzes ATP and an integral V(0) domain that transports protons.
Christina, McGuire, Kristina, Cotter, Laura, Stransky, Michael, Forgac   +3 more
openaire   +3 more sources

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

Cancer Medicine, 2018
Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes.
Bradleigh Whitton, Haruko Okamoto, Graham Packham, Simon J. Crabb   +3 more
doaj   +1 more source

RNA Interference of Genes Encoding the Vacuolar-ATPase in Liriomyza trifolii

Insects, 2021
The leafminer fly, Liriomyza trifolii, is an invasive pest of vegetable and horticultural crops in China. In this study, a microinjection method based on dsRNA was developed for RNA interference (RNAi) in L. trifolii using genes encoding vacuolar-ATPase (
Ya-Wen Chang, Yu-Cheng Wang, Xiao-Xiang Zhang, Junaid Iqbal, Yu-Zhou Du   +4 more
doaj   +1 more source

The Function of V-ATPases in Cancer [PDF]

Physiological Reviews, 2016
The vacuolar ATPases (V-ATPases) are a family of proton pumps that couple ATP hydrolysis to proton transport into intracellular compartments and across the plasma membrane. They function in a wide array of normal cellular processes, including membrane traffic, protein processing and degradation, and the coupled transport of small molecules, as well as ...
Laura, Stransky, Kristina, Cotter, Michael, Forgac   +2 more
openaire   +2 more sources